DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Neurl4 and neurl4

DIOPT Version :10

Sequence 1:NP_648688.2 Gene:Neurl4 / 39558 FlyBaseID:FBgn0283503 Length:1780 Species:Drosophila melanogaster
Sequence 2:NP_001090721.1 Gene:neurl4 / 100036703 XenbaseID:XB-GENE-5825550 Length:1477 Species:Xenopus tropicalis


Alignment Length:1530 Identity:586/1530 - (38%)
Similarity:821/1530 - (53%) Gaps:195/1530 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 HTRCGRSIRLYNNNRMAQRSM--RDFSHALVFSAEPLEDDVLFEVVIEKKNTYWGGSIEIGVTAE 72
            |.|.|:.|.|.|.||.|.|..  ::|:..||.||.||....:|.|.:::|...|.||:|||:|.:
 Frog     5 HPRTGKLISLSNGNRTAARKQPAQEFNQGLVVSARPLGPGEVFTVRLDRKMNSWSGSMEIGLTTQ 69

  Fly    73 SPDDLELVACATAMRNGTWVMSGIDVRKDGRRLFEFYGTDLETLNENDRVGVMRTSGNDLVFYVN 137
            .|..|:..:.||.::.|:|::||..|.:|||.:.|.||.||:.|.|.|||||.|:...:|..:||
 Frog    70 DPAFLDFPSSATGLKGGSWIVSGCSVLEDGRSVLEEYGQDLDQLGEGDRVGVQRSISGELHLWVN 134

  Fly   138 GESQGVAAKNMPKPLWALVDLYGRCVQVSL--C---PRD------GSGSGELLDSPLQQPLQQVV 191
            |...|.|:..:|..:||:|||||:|.|:::  |   |.:      ....|.|:  ||.|......
 Frog   135 GRDCGAASCGIPPRVWAVVDLYGKCTQITVLSCQPPPEEEEEEDAEEQEGSLV--PLGQSRPDKF 197

  Fly   192 QN-LDV-----AMNVNIVVDSDAWMQGNGSVSG----------------ADDRLCFHTRCGSLVK 234
            .| ||.     :..::.||.:......:||:..                .:|.|.||.:||:|:|
 Frog   198 PNSLDTDSGFPSTELSAVVSNAILSAYHGSLLSVSLGSPPAAIEHSPPTCNDALLFHEKCGTLIK 262

  Fly   235 LSPNFRSAERRRPLDEFNNGVVMTHRPLRDNELFEIRIDKLVDKWSGSIEVGVTTHNPAVLHFPA 299
            ||...::|||||||||||||||||:|||||.|:|||||||||||||||||:|||||||..|.:||
 Frog   263 LSNGNKTAERRRPLDEFNNGVVMTNRPLRDCEMFEIRIDKLVDKWSGSIEIGVTTHNPNSLEYPA 327

  Fly   300 TMTNMRSGTIMMSGCGILTNGKGTRRQYGEFNLDELREGDRVGMMRKANGNLHNYINGQDQGVAA 364
            ||||:|||||||||||||||||||||:|.||:||||:|||.:|:.||::|.||.||||.|||||:
 Frog   328 TMTNLRSGTIMMSGCGILTNGKGTRREYCEFSLDELQEGDHIGLTRKSSGALHFYINGMDQGVAS 392

  Fly   365 TRAPSTLWGVIDLYGMTIKVTIVDRDEREQQNLVTRRNNIVAGMTACSSGAGAQHTQHQQHSGTP 429
            .:.|..::||:|||||.:|||||.......:   .||||.:  :.|.|...|       :||.: 
 Frog   393 CQTPPVVYGVVDLYGMAVKVTIVHNHNHADR---LRRNNAI--LRARSPDTG-------RHSSS- 444

  Fly   430 TLSLLSPESEMNAAGAAGGLSETISSTRAIARNDDRLTFHHICGTHATVTQSGRTALRPNAADDF 494
                 :||                         ..:|.||..||..|::...|||||||:|.|||
 Frog   445 -----TPE-------------------------PGQLLFHSNCGQKASIINGGRTALRPHATDDF 479

  Fly   495 NNGVVLTRRPLRPNELFQVRLERVVTKWAGSVEMGVTTHSADELDFPFTMTNVRSGTWMMTGNGV 559
            |:||||:.|||:.||:||||::::|.|||||:|:|||||:...|..|.||||:||||||||||||
 Frog   480 NHGVVLSNRPLQNNEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQLPSTMTNLRSGTWMMTGNGV 544

  Fly   560 MQNGVTVIEQYGQNLDRLQVGDRVGVVRKDDGTLHFWVNGVDQGPAANNVPERVYGVIDLYGQAA 624
            |.||.|::::||.|||||:.||.|||||::||||:|:|||:.||.||.|||..|:.|:|||||||
 Frog   545 MHNGTTILDEYGHNLDRLKAGDTVGVVRREDGTLNFFVNGIAQGVAAWNVPPNVFAVVDLYGQAA 609

  Fly   625 QASIVDTSEC----GSPDTGNSTISNT--TLYSEVPLRFHSIHGANAGISNSGLTASRPNSLAEF 683
            ||:|:|.|:.    |..|.|.:....|  .|.|...||||.:|||||.|:|.|.|..|.||.:||
 Frog   610 QATIMDESDALPLPGDEDEGLALTPGTPCALLSLSDLRFHHLHGANALITNGGRTVLRKNSRSEF 674

  Fly   684 NDAIVFSNRPLRQRELFEVELETMVRHWSGNIEIGVTGTRPEDIQLAPNATDLEASDTIILCGPM 748
            |||||.|:||||..|:||:.::.||..|||:||.|||..||||::.....||:: .||.:|.|..
 Frog   675 NDAIVMSSRPLRDGEMFEIVIQKMVDRWSGSIEAGVTAIRPEDLEFPNTMTDID-YDTWMLSGTA 738

  Fly   749 IFHNRKTIRTNILLDLDTLGPSTRVGVMR--NGDFIHFFVDGMDQGPACECHAP---NIWAIIDL 808
            |..:..|:|.|...|||:||..:|:|:|:  .|| :|:|::|.|||.|| ...|   :|:|:|||
 Frog   739 IMQDGNTLRNNYGCDLDSLGAGSRIGMMKTIRGD-LHYFINGEDQGVAC-TGLPMGRDIYAVIDL 801

  Fly   809 YGQCAQVSLT----QTQLDIRAPYATSENSQSCQATSVIQHPAMETKHRWTCVSG-NVSLTKDWT 868
            ||||.|||||    .....:.|.:.|.::..|       |.|.....||:..|.| |||:..|.|
 Frog   802 YGQCVQVSLTGGSGLVDNSLSASHVTDKSLPS-------QSPVPSVSHRFHTVCGKNVSVLCDGT 859

  Fly   869 EASRFTGAAAPLSHCLVFSEHPLSVGSPFEIKLTSVNSMFAGCLSIGVTDLNLSDES-VRKKLPT 932
            .|.|..|.    ||.:|||...|.....|||::..:...::|..:||||.|:..:.| :...||.
 Frog   860 RAERGAGC----SHGIVFSSRELLTNETFEIRVEKIEPHWSGSCNIGVTSLSPHEVSLLGGGLPE 920

  Fly   933 SIRRIPANV-WYVSGNEVCFNSSCLQRSLA-SLEWLRVDDRITLER-VENSLNILLNSENVNIHF 994
            ....:.:.| |.|.|:||..|...|:.:.. |||.:||..|:.:.| .:::|:||:|.|::....
 Frog   921 RALELRSKVTWLVCGSEVTRNGQRLRENYCNSLERVRVGSRLGVRRDSDDTLHILMNGEDMGPAA 985

  Fly   995 HNVPNDVYVVAELRGSTMGIQVISAQGPASP--LRPCSLRLQDSMDFGVDPLNKQDSSMLESIDS 1057
            ..:|..||.|.::.|....:..:|:.....|  .:|.|:..:...:  .||.:..|...:    .
 Frog   986 CGIPKAVYAVLDIHGCITALSTVSSSLLEEPDATKPPSITSESEEE--EDPADHGDPHTV----I 1044

  Fly  1058 EALNYEFLDVSQKNARLSDDRRSVTRIKSYNQSIVCLNKPLCKGESISIKVDALNNKWKGTVGLG 1122
            :|.:.:||....||..||...|:.||:.||||.||.|.:||.:.....|::|.|:..|..::.:|
 Frog  1045 QAHSLQFLANHGKNILLSHGNRTATRVSSYNQGIVVLPQPLPRLFLFQIRIDQLSPHWTSSLSIG 1109

  Fly  1123 VLSASPQTV--PISLLDFKRSCWLATHDYVNINGQVMPSKYGDALEQIQVGTVITLTLTHAGMLI 1185
            |::.||:.:  |.:....|||.|:.....|..||..:...||..|:....||.:.|.|..:|.|.
 Frog  1110 VIAVSPERLNFPATAAALKRSSWIFQRSAVLCNGVKIREGYGPNLDLCPEGTCLGLLLDSSGGLH 1174

  Fly  1186 IMIGSTNLEDLASGLPNHVYPVFDVYGKCEKITLITGNDAGRTGNANGTPILEAPEALELDNGMP 1250
            :.:...:....|..||...|.:.|:||:||:::::||...|...:|:             :..:|
 Frog  1175 LYVNGLDQGVGAQDLPEVCYVLVDLYGQCEQVSIVTGEAQGAELDAH-------------EGQLP 1226

  Fly  1251 QQCEKAHLEMHEKEKDTEQVCESGPSTSGAPSNAMTRSVMESVSENLLLNISIKNRTLEQQRNEL 1315
            .:.|||  :|.:..|  |.:|...|......|           .|.|.|....|:..|......|
 Frog  1227 GEREKA--DMVDGVK--ESLCWVPPDPVALLS-----------CEYLALCTRFKDLLLLPDGYFL 1276

  Fly  1316 GGSSSTCCLRESLQLQHNTNLNIQRSQSTQRFQNSLNTSATAAGSSGTSGCTANTQ-HLSNSG-- 1377
            ..|....|..:|...........:|....:.:...:...:.....|..|.|....: |::..|  
 Frog  1277 EDSKLCVCHCDSCHKLRGDETYRKRGDPPREYAEPIGWCSFPLRLSPRSSCAQYKKWHIAYQGSS 1341

  Fly  1378 ---VYDTNKEYDDLPNPPNPLVNSVDEASGAITSVSTTIDHSENNAEALELSASNEREMSGEPAL 1439
               :..|....|.||.           ::..:|||....|                 ..||.||.
 Frog  1342 AGTIRRTLDRGDLLPG-----------SACILTSVPAKSD-----------------PQSGFPAA 1378

  Fly  1440 NDNVLEDDEIDYMNHLLLLQQLQQNEYTRHHLMPD 1474
            ..|||...:         ||.:..:...|:..:|:
 Frog  1379 EPNVLPPRD---------LQSVVLSPTLRYAALPE 1404

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Neurl4NP_648688.2 SPRY_NHR_like 8..168 CDD:293945 68/161 (42%)
SPRY_NHR_like 225..387 CDD:293945 119/161 (74%)
SPRY_NHR_like 467..629 CDD:293945 104/161 (65%)
SPRY_NHR_like 656..818 CDD:293945 85/166 (51%)
SPRY_NHR_like 854..1016 CDD:293945 53/166 (32%)
SPRY_NHR_like 1063..1220 CDD:293945 52/158 (33%)
neurl4NP_001090721.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26 10/20 (50%)
SPRY_NHR_like 3..165 CDD:293945 68/159 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 168..196 6/29 (21%)
SPRY_NHR_like 253..415 CDD:293945 119/161 (74%)
SPRY_NHR_like 453..613 CDD:293945 104/159 (65%)
SPRY_NHR_like 647..811 CDD:293945 85/166 (51%)
SPRY_NHR_like 843..1008 CDD:293945 54/168 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1012..1041 6/30 (20%)
SPRY_NHR_like 1050..1209 CDD:293945 52/158 (33%)

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