DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Neurl4 and neurl4

DIOPT Version :9

Sequence 1:	NP_648688.2	Gene:	Neurl4 / 39558	FlyBaseID:	FBgn0283503	Length:	1780	Species:	Drosophila melanogaster
Sequence 2:	NP_001090721.1	Gene:	neurl4 / 100036703	XenbaseID:	XB-GENE-5825550	Length:	1477	Species:	Xenopus tropicalis

Alignment Length:	1530	Identity:	586/1530 - (38%)
Similarity:	821/1530 - (53%)	Gaps:	195/1530 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 HTRCGRSIRLYNNNRMAQRSM--RDFSHALVFSAEPLEDDVLFEVVIEKKNTYWGGSIEIGVTAE 72
            |.|.|:.|.|.|.||.|.|..  ::|:..||.||.||....:|.|.:::|...|.||:|||:|.:
Frog     5 HPRTGKLISLSNGNRTAARKQPAQEFNQGLVVSARPLGPGEVFTVRLDRKMNSWSGSMEIGLTTQ 69

  Fly    73 SPDDLELVACATAMRNGTWVMSGIDVRKDGRRLFEFYGTDLETLNENDRVGVMRTSGNDLVFYVN 137
            .|..|:..:.||.::.|:|::||..|.:|||.:.|.||.||:.|.|.|||||.|:...:|..:||
Frog    70 DPAFLDFPSSATGLKGGSWIVSGCSVLEDGRSVLEEYGQDLDQLGEGDRVGVQRSISGELHLWVN 134

  Fly   138 GESQGVAAKNMPKPLWALVDLYGRCVQVSL--C---PRD------GSGSGELLDSPLQQPLQQVV 191
            |...|.|:..:|..:||:|||||:|.|:::  |   |.:      ....|.|:  ||.|......
Frog   135 GRDCGAASCGIPPRVWAVVDLYGKCTQITVLSCQPPPEEEEEEDAEEQEGSLV--PLGQSRPDKF 197

  Fly   192 QN-LDV-----AMNVNIVVDSDAWMQGNGSVSG----------------ADDRLCFHTRCGSLVK 234
            .| ||.     :..::.||.:......:||:..                .:|.|.||.:||:|:|
Frog   198 PNSLDTDSGFPSTELSAVVSNAILSAYHGSLLSVSLGSPPAAIEHSPPTCNDALLFHEKCGTLIK 262

  Fly   235 LSPNFRSAERRRPLDEFNNGVVMTHRPLRDNELFEIRIDKLVDKWSGSIEVGVTTHNPAVLHFPA 299
            ||...::|||||||||||||||||:|||||.|:|||||||||||||||||:|||||||..|.:||
Frog   263 LSNGNKTAERRRPLDEFNNGVVMTNRPLRDCEMFEIRIDKLVDKWSGSIEIGVTTHNPNSLEYPA 327

  Fly   300 TMTNMRSGTIMMSGCGILTNGKGTRRQYGEFNLDELREGDRVGMMRKANGNLHNYINGQDQGVAA 364
            ||||:|||||||||||||||||||||:|.||:||||:|||.:|:.||::|.||.||||.|||||:
Frog   328 TMTNLRSGTIMMSGCGILTNGKGTRREYCEFSLDELQEGDHIGLTRKSSGALHFYINGMDQGVAS 392

  Fly   365 TRAPSTLWGVIDLYGMTIKVTIVDRDEREQQNLVTRRNNIVAGMTACSSGAGAQHTQHQQHSGTP 429
            .:.|..::||:|||||.:|||||.......:   .||||.:  :.|.|...|       :||.:
Frog   393 CQTPPVVYGVVDLYGMAVKVTIVHNHNHADR---LRRNNAI--LRARSPDTG-------RHSSS- 444

  Fly   430 TLSLLSPESEMNAAGAAGGLSETISSTRAIARNDDRLTFHHICGTHATVTQSGRTALRPNAADDF 494
                 :||                         ..:|.||..||..|::...|||||||:|.|||
Frog   445 -----TPE-------------------------PGQLLFHSNCGQKASIINGGRTALRPHATDDF 479

  Fly   495 NNGVVLTRRPLRPNELFQVRLERVVTKWAGSVEMGVTTHSADELDFPFTMTNVRSGTWMMTGNGV 559
            |:||||:.|||:.||:||||::::|.|||||:|:|||||:...|..|.||||:||||||||||||
Frog   480 NHGVVLSNRPLQNNEVFQVRIDKMVDKWAGSIEIGVTTHNPAYLQLPSTMTNLRSGTWMMTGNGV 544

  Fly   560 MQNGVTVIEQYGQNLDRLQVGDRVGVVRKDDGTLHFWVNGVDQGPAANNVPERVYGVIDLYGQAA 624
            |.||.|::::||.|||||:.||.|||||::||||:|:|||:.||.||.|||..|:.|:|||||||
Frog   545 MHNGTTILDEYGHNLDRLKAGDTVGVVRREDGTLNFFVNGIAQGVAAWNVPPNVFAVVDLYGQAA 609

  Fly   625 QASIVDTSEC----GSPDTGNSTISNT--TLYSEVPLRFHSIHGANAGISNSGLTASRPNSLAEF 683
            ||:|:|.|:.    |..|.|.:....|  .|.|...||||.:|||||.|:|.|.|..|.||.:||
Frog   610 QATIMDESDALPLPGDEDEGLALTPGTPCALLSLSDLRFHHLHGANALITNGGRTVLRKNSRSEF 674

  Fly   684 NDAIVFSNRPLRQRELFEVELETMVRHWSGNIEIGVTGTRPEDIQLAPNATDLEASDTIILCGPM 748
            |||||.|:||||..|:||:.::.||..|||:||.|||..||||::.....||:: .||.:|.|..
Frog   675 NDAIVMSSRPLRDGEMFEIVIQKMVDRWSGSIEAGVTAIRPEDLEFPNTMTDID-YDTWMLSGTA 738

  Fly   749 IFHNRKTIRTNILLDLDTLGPSTRVGVMR--NGDFIHFFVDGMDQGPACECHAP---NIWAIIDL 808
            |..:..|:|.|...|||:||..:|:|:|:  .|| :|:|::|.|||.|| ...|   :|:|:|||
Frog   739 IMQDGNTLRNNYGCDLDSLGAGSRIGMMKTIRGD-LHYFINGEDQGVAC-TGLPMGRDIYAVIDL 801

  Fly   809 YGQCAQVSLT----QTQLDIRAPYATSENSQSCQATSVIQHPAMETKHRWTCVSG-NVSLTKDWT 868
            ||||.|||||    .....:.|.:.|.::..|       |.|.....||:..|.| |||:..|.|
Frog   802 YGQCVQVSLTGGSGLVDNSLSASHVTDKSLPS-------QSPVPSVSHRFHTVCGKNVSVLCDGT 859

  Fly   869 EASRFTGAAAPLSHCLVFSEHPLSVGSPFEIKLTSVNSMFAGCLSIGVTDLNLSDES-VRKKLPT 932
            .|.|..|.    ||.:|||...|.....|||::..:...::|..:||||.|:..:.| :...||.
Frog   860 RAERGAGC----SHGIVFSSRELLTNETFEIRVEKIEPHWSGSCNIGVTSLSPHEVSLLGGGLPE 920

  Fly   933 SIRRIPANV-WYVSGNEVCFNSSCLQRSLA-SLEWLRVDDRITLER-VENSLNILLNSENVNIHF 994
            ....:.:.| |.|.|:||..|...|:.:.. |||.:||..|:.:.| .:::|:||:|.|::....
Frog   921 RALELRSKVTWLVCGSEVTRNGQRLRENYCNSLERVRVGSRLGVRRDSDDTLHILMNGEDMGPAA 985

  Fly   995 HNVPNDVYVVAELRGSTMGIQVISAQGPASP--LRPCSLRLQDSMDFGVDPLNKQDSSMLESIDS 1057
            ..:|..||.|.::.|....:..:|:.....|  .:|.|:..:...:  .||.:..|...:    .
Frog   986 CGIPKAVYAVLDIHGCITALSTVSSSLLEEPDATKPPSITSESEEE--EDPADHGDPHTV----I 1044

  Fly  1058 EALNYEFLDVSQKNARLSDDRRSVTRIKSYNQSIVCLNKPLCKGESISIKVDALNNKWKGTVGLG 1122
            :|.:.:||....||..||...|:.||:.||||.||.|.:||.:.....|::|.|:..|..::.:|
Frog  1045 QAHSLQFLANHGKNILLSHGNRTATRVSSYNQGIVVLPQPLPRLFLFQIRIDQLSPHWTSSLSIG 1109

  Fly  1123 VLSASPQTV--PISLLDFKRSCWLATHDYVNINGQVMPSKYGDALEQIQVGTVITLTLTHAGMLI 1185
            |::.||:.:  |.:....|||.|:.....|..||..:...||..|:....||.:.|.|..:|.|.
Frog  1110 VIAVSPERLNFPATAAALKRSSWIFQRSAVLCNGVKIREGYGPNLDLCPEGTCLGLLLDSSGGLH 1174

  Fly  1186 IMIGSTNLEDLASGLPNHVYPVFDVYGKCEKITLITGNDAGRTGNANGTPILEAPEALELDNGMP 1250
            :.:...:....|..||...|.:.|:||:||:::::||...|...:|:             :..:|
Frog  1175 LYVNGLDQGVGAQDLPEVCYVLVDLYGQCEQVSIVTGEAQGAELDAH-------------EGQLP 1226

  Fly  1251 QQCEKAHLEMHEKEKDTEQVCESGPSTSGAPSNAMTRSVMESVSENLLLNISIKNRTLEQQRNEL 1315
            .:.|||  :|.:..|  |.:|...|......|           .|.|.|....|:..|......|
Frog  1227 GEREKA--DMVDGVK--ESLCWVPPDPVALLS-----------CEYLALCTRFKDLLLLPDGYFL 1276

  Fly  1316 GGSSSTCCLRESLQLQHNTNLNIQRSQSTQRFQNSLNTSATAAGSSGTSGCTANTQ-HLSNSG-- 1377
            ..|....|..:|...........:|....:.:...:...:.....|..|.|....: |::..|
Frog  1277 EDSKLCVCHCDSCHKLRGDETYRKRGDPPREYAEPIGWCSFPLRLSPRSSCAQYKKWHIAYQGSS 1341

  Fly  1378 ---VYDTNKEYDDLPNPPNPLVNSVDEASGAITSVSTTIDHSENNAEALELSASNEREMSGEPAL 1439
               :..|....|.||.           ::..:|||....|                 ..||.||.
Frog  1342 AGTIRRTLDRGDLLPG-----------SACILTSVPAKSD-----------------PQSGFPAA 1378

  Fly  1440 NDNVLEDDEIDYMNHLLLLQQLQQNEYTRHHLMPD 1474
            ..|||...:         ||.:..:...|:..:|:
Frog  1379 EPNVLPPRD---------LQSVVLSPTLRYAALPE 1404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neurl4	NP_648688.2	NEUZ	5..126	CDD:128856	51/117 (44%)
		SPRY_NHR_like	8..168	CDD:293945	68/161 (42%)
		NEUZ	221..345	CDD:128856	96/123 (78%)
		SPRY_NHR_like	225..387	CDD:293945	119/161 (74%)
		NEUZ	464..587	CDD:128856	77/122 (63%)
		SPRY_NHR_like	467..629	CDD:293945	104/161 (65%)
		NEUZ	653..777	CDD:128856	62/123 (50%)
		SPRY_NHR_like	656..818	CDD:293945	85/166 (51%)
		SPRY_NHR_like	854..1016	CDD:293945	53/166 (32%)
		SPRY_NHR_like	1063..1220	CDD:293945	52/158 (33%)
neurl4	NP_001090721.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		10/20 (50%)
		SPRY_NHR_like	3..165	CDD:293945	68/159 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	168..196		6/29 (21%)
		SPRY_NHR_like	253..415	CDD:293945	119/161 (74%)
		SPRY_NHR_like	453..613	CDD:293945	104/159 (65%)
		SPRY_NHR_like	647..811	CDD:293945	85/166 (51%)
		SPRY_NHR_like	843..1008	CDD:293945	54/168 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1012..1041		6/30 (20%)
		SPRY_NHR_like	1050..1209	CDD:293945	52/158 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	260	1.000	Domainoid score	I1937
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13029
Inparanoid	1	1.050	896	1.000	Inparanoid score	I382
OMA	1	1.010	-	-		QHG49525
OrthoDB	1	1.010	-	-		D491552at33208
OrthoFinder	1	1.000	-	-		FOG0007800
OrthoInspector	1	1.000	-	-		oto104222
Panther	1	1.100	-	-	LDO	PTHR12429
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5748
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080