DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70Cb and SSE1

DIOPT Version :9

Sequence 1:	NP_001189103.1	Gene:	Hsc70Cb / 39557	FlyBaseID:	FBgn0026418	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_015219.1	Gene:	SSE1 / 855998	SGDID:	S000006027	Length:	693	Species:	Saccharomyces cerevisiae

Alignment Length:	736	Identity:	262/736 - (35%)
Similarity:	397/736 - (53%)	Gaps:	67/736 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVGGFKR 69
            |:|.||.:..:|.||:.||:.:.|:.|.|:|||.|.|..|.|.:|...||:|.:|:||||...||
Yeast     6 GLDLGNNNSVLAVARNRGIDIVVNEVSNRSTPSVVGFGPKNRYLGETGKNKQTSNIKNTVANLKR 70

  Fly    70 LLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSAAAMQ 134
            ::|..::.|..:.|.....:::....|...|.:|.:.||...|...||.||...|:|:|.....:
Yeast    71 IIGLDYHHPDFEQESKHFTSKLVELDDKKTGAEVRFAGEKHVFSATQLAAMFIDKVKDTVKQDTK 135

  Fly   135 TQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDL--FEDKPRNVI 197
            ..:.|..||.|.::|..:|..:.|||:|||||.:|::|:.||..::||.:|.||  .|:|||.|.
Yeast   136 ANITDVCIAVPPWYTEEQRYNIADAARIAGLNPVRIVNDVTAAGVSYGIFKTDLPEGEEKPRIVA 200

  Fly   198 FVDFGHSSLQASACAFTKGKLKMLASTWDQ-IGGRDIDLALGDYFAKEFQERYKINAKTNARANL 261
            |||.||||...|..||.||:||:|.:..|: .||||.|||:.::||.||:.:|||:.:.|.:|..
Yeast   201 FVDIGHSSYTCSIMAFKKGQLKVLGTACDKHFGGRDFDLAITEHFADEFKTKYKIDIRENPKAYN 265

  Fly   262 RLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLLAESK 326
            |:||..|||||.:||| |..|.::|..::|:||||.:.|.::|||..|:|:||.:...:.||::|
Yeast   266 RILTAAEKLKKVLSAN-TNAPFSVESVMNDVDVSSQLSREELEELVKPLLERVTEPVTKALAQAK 329

  Fly   327 LQLDDIHSVEIVGGSSRIPSVKQLIEQVFNKPASTTLNQDEAVSRGAALQCAIMSPAVRVREFGV 391
            |..:::..|||:||::|||::||.|.:.|.||.|||||||||:::|||..|||.||.:|||.|..
Yeast   330 LSAEEVDFVEIIGGTTRIPTLKQSISEAFGKPLSTTLNQDEAIAKGAAFICAIHSPTLRVRPFKF 394

  Fly   392 TDIQNYAVKVLWDSEGSAAPGEIEIFPQYHASPFSRLLTINRKGPFNVSIVYGQQVPYPDQT--- 453
            .||..|:|...||.: ......:|:||...:.|.::|:|:||.|.|:::..|......|..|
Yeast   395 EDIHPYSVSYSWDKQ-VEDEDHMEVFPAGSSFPSTKLITLNRTGDFSMAASYTDITQLPPNTPEQ 458

  Fly   454 IGVWKVKDVKPTERGEGQD---VKLKVRINNNGIVLISSATLVEKKEAEEAAAAAEQAASEEKPG 515
            |..|::..|   :..||||   ||||:|.:.:|:..|..|..:|..|.||.....|.|
Yeast   459 IANWEITGV---QLPEGQDSVPVKLKLRCDPSGLHTIEEAYTIEDIEVEEPIPLPEDA------- 513

  Fly   516 DQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGSGADKKKKASKATELPLEC 580
                    |.|.:||                                 ..|..|..|..:|.:..
Yeast   514 --------PEDAEQE---------------------------------FKKVTKTVKKDDLTIVA 537

  Fly   581 TTHGFSPVDLSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQGGPFERYVVEAEREKI 645
            .|.|.....|:...::|::|:..|:...|..|.||.|||::|.:|.||: ..:..:..:||:.|:
Yeast   538 HTFGLDAKKLNELIEKENEMLAQDKLVAETEDRKNTLEEYIYTLRGKLE-EEYAPFASDAEKTKL 601

  Fly   646 VSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPIKLR--ASDYEQGPA--AFDELKNSIAIA 706
            ...||..|.|||::|.|..:..|.::.:.|....:.|:.|  |.:.|:..|  :..|.....|:|
Yeast   602 QGMLNKAEEWLYDEGFDSIKAKYIAKYEELASLGNIIRGRYLAKEEEKKQAIRSKQEASQMAAMA 666

  Fly   707 RLAVAEFRKGVPKYDHLTETE 727
            ....|:.:....|.:...:||
Yeast   667 EKLAAQRKAEAEKKEEKKDTE 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	166/378 (44%)
Hsc70Cb	NP_001189103.1	HSP70	3..682	CDD:278441	250/685 (36%)
SSE1	NP_015219.1	HSP70	4..644	CDD:394970	252/691 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346679
Domainoid	1	1.000	430	1.000	Domainoid score	I69
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1624
Inparanoid	1	1.050	431	1.000	Inparanoid score	I275
Isobase	1	0.950	-	0	Normalized mean entropy	S1071
OMA	1	1.010	-	-		QHG54058
OrthoFinder	1	1.000	-	-		FOG0001023
OrthoInspector	1	1.000	-	-		otm46488
orthoMCL	1	0.900	-	-		OOG6_100680
Panther	1	1.100	-	-	LDO	PTHR45639
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R574
SonicParanoid	1	1.000	-	-		X684
TreeFam	1	0.960	-	-
	16	15.740