Protein Alignment Hsp110 and LHS1

DIOPT Version :10

• Sequence 1: NP_001189103.1
• Gene: Hsp110 / 39557
• FlyBaseID: FBgn0026418
• Length: 836
• Species: Drosophila melanogaster
• Sequence 2: NP_012850.1
• Gene: LHS1 / 853789
• SGDID: S000001556
• Length: 881
• Species: Saccharomyces cerevisiae
• Alignment Length: 843
• Identity: 176/843 - (20%)
• Similarity: 322/843 - (38%)
• Gaps: 167/843 - (19%)

  Fly     2 SVIGIDFGNESC-YVAAARSGGIETL---------ANDYSLRATPSFVAFD--GKKRIIGVAAKN 54
            :|:|:|:|.::. .:..:....:|.:         .:..|::..|.:...|  |.:||.|.|..:
Yeast    21 AVLGVDYGQQNIKAIVVSPQAPLELVLTPEAKRKEISGLSIKRLPGYGKDDPNGIERIYGSAVGS 85

  Fly    55 QQVTNMKNTVGGFKRLLGRKFNDPHV------QH---ELTSIPARVEARGDGSIGIKVNYLGEDQ 110
            ......:||:...|.|||:...|...      ||   |:.|.....           :.:|.::.
Yeast    86 LATRFPQNTLLHLKPLLGKSLEDETTVTLYSKQHPGLEMVSTNRST-----------IAFLVDNV 139

  Fly   111 HFGPEQLTAMLFTKLKETSAAAMQTQ-------VNDCVIACPVFFTNAERKALLDAAQI-AGLNV 167
            .:..|:|.||...::...:.:.::.:       ||......|.||...:|||||||:.| .|:..
Yeast   140 EYPLEELVAMNVQEIANRANSLLKDRDARTEDFVNKMSFTIPDFFDQHQRKALLDASSITTGIEE 204

  Fly   168 LRLMNETTATALAYGFYKNDLFEDKPRNVIFVDFGHSSLQASACAFTKGKLKMLASTWD------ 226
            ..|::|..:.|:.:...:......:.::.|..|.|..|::||..:..:.:......|.:
Yeast   205 TYLVSEGMSVAVNFVLKQRQFPPGEQQHYIVYDMGSGSIKASMFSILQPEDTTQPVTIEFEGYGY 269

  Fly   227 --QIGGRDIDLALGDYFAKEFQERYKINAKTNARANLRLLTEI----EKLKKQMSANSTKLPLNI 285
              .:||....:.:|.....:|.|.:.........||.:.|.:|    ||.|..:|||| :..:||
Yeast   270 NPHLGGAKFTMDIGSLIENKFLETHPAIRTDELHANPKALAKINQAAEKAKLILSANS-EASINI 333

  Fly   286 ECFLDDIDVSSSMQRSQMEELCA----PVLQRVEQTFKRLLAESKLQLDDIHSVEIVGGSSRIPS 346
            |..::|||..:|:.|.:.||..|    .:::.:.....:........|.:|:.|.:.|||||||.
Yeast   334 ESLINDIDFRTSITRQEFEEFIADSLLDIVKPINDAVTKQFGGYGTNLPEINGVILAGGSSRIPI 398

  Fly   347 VK-QLIEQVFNKPASTTLNQDEAVSRGAALQCAIMSPAVRVREFGVTD--IQNYAVKVLWDSEGS 408
            |: |||:.|..:.....:|.||:...|..::...:|.:.:.:...|.|  :..|:.|:
Yeast   399 VQDQLIKLVSEEKVLRNVNADESAVNGVVMRGIKLSNSFKTKPLNVVDRSVNTYSFKL------- 456

  Fly   409 AAPGEIEIFPQYHASPFSRLLTINRKGPFNVSIVYGQQVPYPDQTIGVWKVKDVKPTERGEGQDV 473
              ..|.|::.                       |:.:...||::|..:....|..|
Yeast   457 --SNESELYD-----------------------VFTRGSAYPNKTSILTNTTDSIP--------- 487

  Fly   474 KLKVRINNNGIVLISSATLVEKKEAEEAAAAAEQAASEEKPGDQTNNTGEPADGQ----QEAYCE 534
                  ||..|.|..:..|.|.......|.....::.:...|...|.|.:.:..:    ||..|.
Yeast   488 ------NNFTIDLFENGKLFETITVNSGAIKNSYSSDKCSSGVAYNITFDLSSDRLFSIQEVNCI 546

  Fly   535 NEDDNNTSTASSPGGQGWAQRVKGWFGSGADKKKKASKATELPLECTTHGFSPVDLSNYTQQESK 599
            .:.:|:                   .|:....|.|.|:......:......||.:.|. ..:..|
Yeast   547 CQSEND-------------------IGNSKQIKNKGSRLAFTSEDVEIKRLSPSERSR-LHEHIK 591

  Fly   600 MIGNDQKETERIDAK---NALEEFVYDMRNKL------QGGPFERYVVEAEREKIVSQLNDLENW 655
            ::  |:::.||...:   |.||..:||.||.|      |.||      :::.|::...:....:|
Yeast   592 LL--DKQDKERFQFQENLNVLESNLYDARNLLMDDEVMQNGP------KSQVEELSEMVKVYLDW 648

  Fly   656 LYEDGEDCERDIYTSRLQALHQKTDPIKLRASDYEQGPAAFDELKNSIAIAR---LAVAEFRKGV 717
            |.:...|.:.:...||::.:......|:| ..|..:.|....:.|..:....   .|:...:..|
Yeast   649 LEDASFDTDPEDIVSRIREIGILKKKIEL-YMDSAKEPLNSQQFKGMLEEGHKLLQAIETHKNTV 712

  Fly   718 PKYDHLTETEFINISETADKAQSWLDANLPKFTQSPRTADSPVQIS-AVRQEVQTLNSCVSSV 779
            .::....||||   ::|.|..:.    ...|..|       |..:| |:....:||.|..:|:
Yeast   713 EEFLSQFETEF---ADTIDNVRE----EFKKIKQ-------PAYVSKALSTWEETLTSFKNSI 761

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp110	NP_001189103.1	ASKHA_NBD_HSP70_HSPA4_like	4..378	CDD:466826	98/419 (23%)
LHS1	NP_012850.1	ASKHA_NBD_HSP70_HYOU1	21..431	CDD:466828	99/421 (24%)