DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70Cb and LHS1

DIOPT Version :9

Sequence 1:	NP_001189103.1	Gene:	Hsc70Cb / 39557	FlyBaseID:	FBgn0026418	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_012850.1	Gene:	LHS1 / 853789	SGDID:	S000001556	Length:	881	Species:	Saccharomyces cerevisiae

Alignment Length:	843	Identity:	176/843 - (20%)
Similarity:	322/843 - (38%)	Gaps:	167/843 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SVIGIDFGNESC-YVAAARSGGIETL---------ANDYSLRATPSFVAFD--GKKRIIGVAAKN 54
            :|:|:|:|.::. .:..:....:|.:         .:..|::..|.:...|  |.:||.|.|..:
Yeast    21 AVLGVDYGQQNIKAIVVSPQAPLELVLTPEAKRKEISGLSIKRLPGYGKDDPNGIERIYGSAVGS 85

  Fly    55 QQVTNMKNTVGGFKRLLGRKFNDPHV------QH---ELTSIPARVEARGDGSIGIKVNYLGEDQ 110
            ......:||:...|.|||:...|...      ||   |:.|.....           :.:|.::.
Yeast    86 LATRFPQNTLLHLKPLLGKSLEDETTVTLYSKQHPGLEMVSTNRST-----------IAFLVDNV 139

  Fly   111 HFGPEQLTAMLFTKLKETSAAAMQTQ-------VNDCVIACPVFFTNAERKALLDAAQI-AGLNV 167
            .:..|:|.||...::...:.:.::.:       ||......|.||...:|||||||:.| .|:..
Yeast   140 EYPLEELVAMNVQEIANRANSLLKDRDARTEDFVNKMSFTIPDFFDQHQRKALLDASSITTGIEE 204

  Fly   168 LRLMNETTATALAYGFYKNDLFEDKPRNVIFVDFGHSSLQASACAFTKGKLKMLASTWD------ 226
            ..|::|..:.|:.:...:......:.::.|..|.|..|::||..:..:.:......|.:
Yeast   205 TYLVSEGMSVAVNFVLKQRQFPPGEQQHYIVYDMGSGSIKASMFSILQPEDTTQPVTIEFEGYGY 269

  Fly   227 --QIGGRDIDLALGDYFAKEFQERYKINAKTNARANLRLLTEI----EKLKKQMSANSTKLPLNI 285
              .:||....:.:|.....:|.|.:.........||.:.|.:|    ||.|..:|||| :..:||
Yeast   270 NPHLGGAKFTMDIGSLIENKFLETHPAIRTDELHANPKALAKINQAAEKAKLILSANS-EASINI 333

  Fly   286 ECFLDDIDVSSSMQRSQMEELCA----PVLQRVEQTFKRLLAESKLQLDDIHSVEIVGGSSRIPS 346
            |..::|||..:|:.|.:.||..|    .:::.:.....:........|.:|:.|.:.|||||||.
Yeast   334 ESLINDIDFRTSITRQEFEEFIADSLLDIVKPINDAVTKQFGGYGTNLPEINGVILAGGSSRIPI 398

  Fly   347 VK-QLIEQVFNKPASTTLNQDEAVSRGAALQCAIMSPAVRVREFGVTD--IQNYAVKVLWDSEGS 408
            |: |||:.|..:.....:|.||:...|..::...:|.:.:.:...|.|  :..|:.|:
Yeast   399 VQDQLIKLVSEEKVLRNVNADESAVNGVVMRGIKLSNSFKTKPLNVVDRSVNTYSFKL------- 456

  Fly   409 AAPGEIEIFPQYHASPFSRLLTINRKGPFNVSIVYGQQVPYPDQTIGVWKVKDVKPTERGEGQDV 473
              ..|.|::.                       |:.:...||::|..:....|..|
Yeast   457 --SNESELYD-----------------------VFTRGSAYPNKTSILTNTTDSIP--------- 487

  Fly   474 KLKVRINNNGIVLISSATLVEKKEAEEAAAAAEQAASEEKPGDQTNNTGEPADGQ----QEAYCE 534
                  ||..|.|..:..|.|.......|.....::.:...|...|.|.:.:..:    ||..|.
Yeast   488 ------NNFTIDLFENGKLFETITVNSGAIKNSYSSDKCSSGVAYNITFDLSSDRLFSIQEVNCI 546

  Fly   535 NEDDNNTSTASSPGGQGWAQRVKGWFGSGADKKKKASKATELPLECTTHGFSPVDLSNYTQQESK 599
            .:.:|:                   .|:....|.|.|:......:......||.:.|. ..:..|
Yeast   547 CQSEND-------------------IGNSKQIKNKGSRLAFTSEDVEIKRLSPSERSR-LHEHIK 591

  Fly   600 MIGNDQKETERIDAK---NALEEFVYDMRNKL------QGGPFERYVVEAEREKIVSQLNDLENW 655
            ::  |:::.||...:   |.||..:||.||.|      |.||      :::.|::...:....:|
Yeast   592 LL--DKQDKERFQFQENLNVLESNLYDARNLLMDDEVMQNGP------KSQVEELSEMVKVYLDW 648

  Fly   656 LYEDGEDCERDIYTSRLQALHQKTDPIKLRASDYEQGPAAFDELKNSIAIAR---LAVAEFRKGV 717
            |.:...|.:.:...||::.:......|:| ..|..:.|....:.|..:....   .|:...:..|
Yeast   649 LEDASFDTDPEDIVSRIREIGILKKKIEL-YMDSAKEPLNSQQFKGMLEEGHKLLQAIETHKNTV 712

  Fly   718 PKYDHLTETEFINISETADKAQSWLDANLPKFTQSPRTADSPVQIS-AVRQEVQTLNSCVSSV 779
            .::....||||   ::|.|..:.    ...|..|       |..:| |:....:||.|..:|:
Yeast   713 EEFLSQFETEF---ADTIDNVRE----EFKKIKQ-------PAYVSKALSTWEETLTSFKNSI 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	99/424 (23%)
Hsc70Cb	NP_001189103.1	HSP70	3..682	CDD:278441	154/739 (21%)
LHS1	NP_012850.1	HYOU1-like_NBD	23..430	CDD:212672	98/418 (23%)
LHS1	NP_012850.1	Smc	<581..737	CDD:224117	35/172 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810