DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsc70Cb and Hspa2

DIOPT Version :9

Sequence 1:NP_001189103.1 Gene:Hsc70Cb / 39557 FlyBaseID:FBgn0026418 Length:836 Species:Drosophila melanogaster
Sequence 2:NP_068635.1 Gene:Hspa2 / 60460 RGDID:620664 Length:633 Species:Rattus norvegicus


Alignment Length:706 Identity:195/706 - (27%)
Similarity:334/706 - (47%) Gaps:111/706 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 IGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVGGFK 68
            ||||.|.....|...:.|.:|.:|||...|.|||:|||...:|:||.|||||...|..||:...|
  Rat     8 IGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTIFDAK 72

  Fly    69 RLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSAAAM 133
            ||:||||.|..||.::...|.||.:.| |...::|.|.||.:.|.||::::|:.||:||.:.|.:
  Rat    73 RLIGRKFEDATVQSDMKHWPFRVVSEG-GKPKVQVEYKGEMKTFFPEEISSMVLTKMKEIAEAYL 136

  Fly   134 QTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDLFEDKPRNVIF 198
            ..:|...||..|.:|.:::|:|..||..|.||||||::||.||.|:|||..|......: :||:.
  Rat   137 GGKVQSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGE-KNVLI 200

  Fly   199 VDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKTNARANLR 262
            .|.|..:...|......|..::.::..| .:||.|.|..:..:.|:||:.::|.:...|.||..|
  Rat   201 FDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRAVRR 265

  Fly   263 LLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLLAESKL 327
            |.|..|:.|:.:| :||:..:.|:...:.:|..:|:.|::.|||.|.:.:...:..::.|.::||
  Rat   266 LRTACERAKRTLS-SSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDAKL 329

  Fly   328 QLDDIHSVEIVGGSSRIPSVKQLIEQVFN-KPASTTLNQDEAVSRGAALQCAIM--SPAVRVREF 389
            ....|..:.:||||:|||.:::|::..|| |..:.::|.||||:.|||:|.||:  ..:..|::.
  Rat   330 DKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQDL 394

  Fly   390 GVTDIQNYAVKV---------LWDSEGSAAPGEIEIFPQYHASPFSRLLTINRKGPFNVSIVYGQ 445
            .:.|:...::.:         |.....:....:.:.|..|..:..|.|          |.:..|:
  Rat   395 LLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVL----------VQVYEGE 449

  Fly   446 QVPYPDQT-IGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAEEAAAAAEQAA 509
            :....|.. :|.:.:..:.|..||..| :::...|:.|||:.::               ||:::.
  Rat   450 RAMTKDNNLLGKFDLTGIPPAPRGVPQ-IEVTFDIDANGILNVT---------------AADKST 498

  Fly   510 SEEKPGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGSGADKKKKASKAT 574
            .:|.....||:.|.                                                   
  Rat   499 GKENKITITNDKGR--------------------------------------------------- 512

  Fly   575 ELPLECTTHGFSPVDLSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQGGPFERYVVE 639
                      .|..|:....|:.......|:...:|:.||||:|.:.|:::..::.......:.|
  Rat   513 ----------LSKDDIDRMVQEADGYKSEDEANRDRVAAKNAVESYTYNIKQTVEDEKLRGKISE 567

  Fly   640 AEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPI--KLRASDYEQGP 693
            .::.||:.:..::.||| :..:..|:|.|..:.:.|.:..:||  ||    |:.||
  Rat   568 QDKNKILDKCQEVINWL-DRNQMAEKDEYEHKQKELERVCNPIISKL----YQGGP 618

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsc70CbNP_001189103.1 HSPA4_like_NDB 2..381 CDD:212670 142/380 (37%)
HSP70 3..682 CDD:278441 188/691 (27%)
Hspa2NP_068635.1 PTZ00009 2..615 CDD:240227 192/701 (27%)
Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142 2..389 142/383 (37%)
HSPA1-2_6-8-like_NBD 7..383 CDD:212675 141/377 (37%)
Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142 397..512 23/140 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 613..633 4/10 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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