DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsp110 and hspa8

DIOPT Version :10

Sequence 1:NP_001189103.1 Gene:Hsp110 / 39557 FlyBaseID:FBgn0026418 Length:836 Species:Drosophila melanogaster
Sequence 2:NP_001103873.1 Gene:hspa8 / 573376 ZFINID:ZDB-GENE-990415-92 Length:649 Species:Danio rerio


Alignment Length:690 Identity:188/690 - (27%)
Similarity:336/690 - (48%) Gaps:101/690 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 IGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVGGFK 68
            :|||.|.....|...:.|.:|.:|||...|.|||:|||...:|:||.|||||...|..|||...|
Zfish     7 VGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFDAK 71

  Fly    69 RLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSAAAM 133
            ||:||:|:|..||.::...|..| ...:....::|.|.||.:.|.||::::|:.||:||.:.|.:
Zfish    72 RLIGRRFDDGVVQSDMKHWPFNV-INDNSRPKVQVEYKGESKSFYPEEISSMVLTKMKEIAEAYL 135

  Fly   134 QTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDLFEDKPRNVIF 198
            ...|::.||..|.:|.:::|:|..||..|:||||||::||.||.|:|||..|....|   |||:.
Zfish   136 GKTVSNAVITVPAYFNDSQRQATKDAGTISGLNVLRIINEPTAAAIAYGLDKKVGAE---RNVLI 197

  Fly   199 VDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKTNARANLR 262
            .|.|..:...|......|..::.::..| .:||.|.|..:.::|..||:.::|.:...|.||..|
Zfish   198 FDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFITEFKRKHKKDISDNKRAVRR 262

  Fly   263 LLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLLAESKL 327
            |.|..|:.|:.:| :||:..:.|:...:.||..:|:.|::.|||.|.:.:......::.|.::|:
Zfish   263 LRTACERAKRTLS-SSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKM 326

  Fly   328 QLDDIHSVEIVGGSSRIPSVKQLIEQVFN-KPASTTLNQDEAVSRGAALQCAIMS--PAVRVREF 389
            ....||.:.:||||:|||.:::|::..|| |..:.::|.||||:.|||:|.||:|  .:..|::.
Zfish   327 DKAQIHDIVLVGGSTRIPKIQKLLQDYFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDL 391

  Fly   390 GVTDIQNYAVKVLWDSEGSAAPGEIEIFPQYHAS-PFSRLLTI-----NRKGPFNVSIVYGQQVP 448
            .:.|:...::.:      ..|.|.:.:..:.:.: |..:..|.     |:.|.. :.:..|::..
Zfish   392 LLLDVTPLSLGI------ETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVL-IQVYEGERAM 449

  Fly   449 YPDQT-IGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAEEAAAAAEQAASEE 512
            ..|.. :|.:::..:.|..||..| :::...|:.|||:.:|               |.:::..:|
Zfish   450 TKDNNLLGKFELTGIPPAPRGVPQ-IEVTFDIDANGIMNVS---------------AVDKSTGKE 498

  Fly   513 KPGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGSGADKKKKASKATELP 577
            .....||:.|.                                                      
Zfish   499 NKITITNDKGR------------------------------------------------------ 509

  Fly   578 LECTTHGFSPVDLSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQGGPFERYVVEAER 642
                   .|..|:....|:..|....|..:.:::.|||.||.:.::|::.::....:..:.:.::
Zfish   510 -------LSKEDIERMVQEAEKYKAEDDVQRDKVSAKNGLESYAFNMKSTVEDEKLKGKISDEDK 567

  Fly   643 EKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPI 682
            :||:.:.|::..|| :..:..||:.:..:.:.|.:..:||
Zfish   568 QKILDKCNEVIGWL-DKNQTAEREEFEHQQKELEKVCNPI 606

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsp110NP_001189103.1 ASKHA_NBD_HSP70_HSPA4_like 4..378 CDD:466826 139/375 (37%)
hspa8NP_001103873.1 PTZ00009 1..614 CDD:240227 188/690 (27%)
Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142 2..386 142/383 (37%)
Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142 394..509 23/137 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 614..649
Blue background indicates that the domain is not in the aligned region.

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