DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70Cb and hsph1

DIOPT Version :9

Sequence 1:	NP_001189103.1	Gene:	Hsc70Cb / 39557	FlyBaseID:	FBgn0026418	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	XP_001919957.2	Gene:	hsph1 / 557824	ZFINID:	ZDB-GENE-120410-4	Length:	901	Species:	Danio rerio

Alignment Length:	821	Identity:	323/821 - (39%)
Similarity:	497/821 - (60%)	Gaps:	28/821 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVIGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVG 65
            |:|:|.|.|.::|.:|..:||||||::|:::.|.|||.::|..|.|.||.|||||.:||..:||.
Zfish    63 MAVVGFDVGFQNCCIAVVKSGGIETVSNEFTDRCTPSVISFGSKNRAIGNAAKNQMITNPSSTVF 127

  Fly    66 GFKRLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSA 130
            .||||..|.::|..||.|..::|..:....||.:|::|.||.::.||..||::|||.||||:.:.
Zfish   128 HFKRLHSRLYHDKVVQAEKANLPYDLVPLNDGKVGVQVMYLDQEHHFSIEQISAMLLTKLKDIAE 192

  Fly   131 AAMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDL--FEDKP 193
            |.:|.:|.:|||:.|.|||::||:::||||:|||||.|:|||::||.||.||.||.||  .::.|
Zfish   193 ANLQKKVLECVISIPSFFTDSERRSVLDAAKIAGLNCLKLMNDSTAVALNYGIYKEDLPGSDENP 257

  Fly   194 RNVIFVDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKTNA 257
            :.|.|||.|||:.|.|.|||.:||:|:|::.:| .:||:|.|..|.|:|..||:.:|.::.|:..
Zfish   258 KIVAFVDLGHSAFQVSICAFNRGKVKVLSTAFDPYLGGKDFDQRLVDHFCAEFKSKYMMDVKSKT 322

  Fly   258 RANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLL 322
            ||.|||..|.|||||.||:|||:|.||||||:||.||...|.|::.||:||.:::||:.|..:.:
Zfish   323 RALLRLTQECEKLKKLMSSNSTELSLNIECFIDDKDVCGRMNRAKFEEMCADLIERVKFTLMKAV 387

  Fly   323 AESKLQLDDIHSVEIVGGSSRIPSVKQLIEQVFNKPASTTLNQDEAVSRGAALQCAIMSPAVRVR 387
            .::.::|.||.:||||||::|||:||..|...|.:..|||||.||||:||.|||||::|||.|||
Zfish   388 EQAGVRLQDISAVEIVGGATRIPAVKAQISSFFRRDVSTTLNADEAVARGCALQCAMLSPAFRVR 452

  Fly   388 EFGVTDIQNYAVKVLWDSEGSAAPGEIEIFPQYHASPFSRLLTINRKGPFNVSIVYGQQ--VPYP 450
            ||.:||:..:.:.:.|.||........|||.:.|..|.::::|..|..||.:...|..:  :|:|
Zfish   453 EFSITDVIPFPISLSWSSEADEGKSCHEIFSRNHPCPSAKMITFYRNKPFILEAFYSDKSSLPFP 517

  Fly   451 DQTIGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAEEAAAAAEQAASEEKPG 515
            :..||.:||::::|.|..|...||:||.:|.:|:|.:|||.:|.:..::|:...   ..:|:...
Zfish   518 EAKIGEYKVQNIQPQENREKAKVKVKVEVNRSGVVSVSSAAVVLRVRSDESEIT---EINEDVDS 579

  Fly   516 DQTNNTGEPADGQQEAYCE-NEDDNNTSTASSP-----GGQGWAQRVKGWFGSGADKKKKAS--- 571
            ...::..:..|..:|...| :.:..|..||..|     ..|.....:.|...|.....|||.
Zfish   580 HDASDDTDVQDKTEEVNIELSVNKENLPTAQCPPMEKEQNQRETLSMNGEVNSHPPHAKKAKMKV 644

  Fly   572 KATELPLECTTHGFSPVD-LSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQGGPFER 635
            |...||:|.|.:...|.| ||.||:||:|||..|::|.||.:||||:||.||..|:||:|. ::.
Zfish   645 KHVVLPMEETFNQQLPKDRLSAYTEQENKMIQQDRQEKERNNAKNAVEENVYYFRHKLEGS-YQT 708

  Fly   636 YVVEAEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPIKLRASDYEQGPAAFDELK 700
            ::...|.:.....||..|||||::|.|.::..|.:||..:|:...|::.|..:..:.|..|:||.
Zfish   709 FLNAQEHQAFSELLNGTENWLYDEGADQDKQTYINRLAEIHKLGLPVENRYRESIRRPRMFEELS 773

  Fly   701 NSIAIARLAVAEFRKGVPKYDHLTETEFINISETADKAQSWLDANLPKFTQSPRTADS--PVQIS 763
            ..|......|.:::.|...|.|:...:...:.......|.|: .|: :.:|...|.|.  .:..:
Zfish   774 AKIQSYMTIVEDYKNGSESYCHIDAMDMDKVRVCVKDTQVWM-TNI-QDSQDKLTPDQEPAIHST 836

  Fly   764 AVRQEVQTLNSCVSSVINRAKPKPTPAKTATPPKDEANAEQ 804
            .:::::||||:....::  :||||   :..:|..|....|:
Zfish   837 QIQKKLQTLNNVCGEIV--SKPKP---RVDSPMDDTIQPER 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	190/381 (50%)
Hsc70Cb	NP_001189103.1	HSP70	3..682	CDD:278441	294/693 (42%)
hsph1	XP_001919957.2	HSPH1_NBD	64..446	CDD:212689	190/381 (50%)
hsph1	XP_001919957.2	HSP70	65..761	CDD:278441	296/699 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592210
Domainoid	1	1.000	614	1.000	Domainoid score	I182
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	678	1.000	Inparanoid score	I694
OMA	1	1.010	-	-		QHG54058
OrthoDB	1	1.010	-	-		D285748at33208
OrthoFinder	1	1.000	-	-		FOG0001023
OrthoInspector	1	1.000	-	-		otm25120
orthoMCL	1	0.900	-	-		OOG6_100680
Panther	1	1.100	-	-	O	PTHR45639
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X684
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.810