DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70Cb and ANKRD45

DIOPT Version :9

Sequence 1:	NP_001189103.1	Gene:	Hsc70Cb / 39557	FlyBaseID:	FBgn0026418	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	XP_016856612.1	Gene:	ANKRD45 / 339416	HGNCID:	24786	Length:	286	Species:	Homo sapiens

Alignment Length:	291	Identity:	61/291 - (20%)
Similarity:	105/291 - (36%)	Gaps:	76/291 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   494 EKKEAEEAAAAAEQAASEEKPGDQTNNTGEPADGQQEAY--CEN-----------EDD---NNTS 542
            :::|.||..|...:....:.|..|...||: .:|.|:.:  .||           |:|   .|..
Human    38 QEEENEEEEAQEPEETGPKNPLLQPALTGD-VEGLQKIFEDPENPHHEQAMQLLLEEDIVGRNLL 101

  Fly   543 TASSPGGQGWAQRVKGWFGSGADKKKKASKATELPLECTTHGFSPVDLSNYTQQESKMIGNDQKE 607
            .|:...||....|....:|...::|             ||.|::.:..:              ..
Human   102 YAACMAGQSDVIRALAKYGVNLNEK-------------TTRGYTLLHCA--------------AA 139

  Fly   608 TERIDAKNALEEFVYDMRNKLQGGPFERYVVEAEREK-IVSQLNDLENWLYEDGEDCERDIYTSR 671
            ..|::...||.|...|:         |......||.: :.::.:..|...:.|..|       :|
Human   140 WGRLETLKALVELDVDI---------EALNFREERARDVAARYSQTECVEFLDWAD-------AR 188

  Fly   672 LQALHQKTDPIKLRASDYEQGPA-AFDELKNSIAIARLAVAEFRKGVPKYDHLTETEFINISETA 735
            | .|.:....:.|..:|.|:|.. ...|.||:|..|..|..|:.:        |.|| .:|:|..
Human   189 L-TLKKYIAKVSLAVTDTEKGSGKLLKEDKNTILSACRAKNEWLE--------THTE-ASINELF 243

  Fly   736 DKAQSWLDANLPKFTQSPRTADSPVQISAVR 766
            ::.|...|...|.||:    ..:|.|:.:.:
Human   244 EQRQQLEDIVTPIFTK----MTTPCQVKSAK 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670
Hsc70Cb	NP_001189103.1	HSP70	3..682	CDD:278441	38/204 (19%)
ANKRD45	XP_016856612.1	ANK repeat	58..94	CDD:293786	9/36 (25%)
		ANK	94..>182	CDD:238125	20/123 (16%)
		Ank_4	97..150	CDD:290365	12/79 (15%)
		ANK repeat	97..127	CDD:293786	7/42 (17%)
		ANK repeat	129..160	CDD:293786	7/53 (13%)
		Ank_4	130..182	CDD:290365	10/74 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900