DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70Cb and pss1

DIOPT Version :9

Sequence 1:	NP_001189103.1	Gene:	Hsc70Cb / 39557	FlyBaseID:	FBgn0026418	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_001342976.1	Gene:	pss1 / 3361514	PomBaseID:	SPAC110.04c	Length:	720	Species:	Schizosaccharomyces pombe

Alignment Length:	734	Identity:	275/734 - (37%)
Similarity:	411/734 - (55%)	Gaps:	60/734 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SVIGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVGG 66
            :|:||||||....:|.||:..|:.:.|:.|.|:|||.|::..:.|.:|.|||:.:.:|.:||||.
pombe     6 NVVGIDFGNSKTVIAVARNRAIDVIVNEVSNRSTPSLVSYGERSRFLGEAAKSAEASNFRNTVGS 70

  Fly    67 FKRLLGRKFNDPHVQH-ELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSA 130
            .|||.||.::||.::. |...|.|:: ...||.:|.||.||.|:..|...||.|..|||:|..:.
pombe    71 LKRLAGRTYDDPEIKDIESNFISAKL-TEVDGFVGAKVQYLNEETAFSNIQLIAAYFTKIKAIAE 134

  Fly   131 AAMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDLFE-DKPR 194
            |.:...|:|.||:.|.:||:.:|:|||:||.|||||.|||||:..|.||.||..|.||.| :.||
pombe   135 AELIGSVSDVVISIPAWFTDIQRRALLEAANIAGLNPLRLMNDNAAAALTYGITKTDLPEPESPR 199

  Fly   195 NVIFVDFGHSSLQASACAFTKGKLKMLASTWDQ-IGGRDIDLALGDYFAKEFQERYKINAKTNAR 258
            .|..||||||:...|...|::|:..:.::..|: :|.|::|.||.||||.||:|:|||:..:|.:
pombe   200 RVAIVDFGHSNYSVSIVEFSRGQFHIKSTVCDRNLGSRNMDKALIDYFAAEFKEKYKIDVLSNPK 264

  Fly   259 ANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLLA 323
            |..||.|.:|:|||.:|||: ..|||:|..::|||.||.::||..|||..|:|:|:....::.|.
pombe   265 ATFRLATAVERLKKVLSANA-NAPLNVEMIMNDIDASSFIKRSDFEELIKPLLERLTPPIEKALE 328

  Fly   324 ESKLQLDDIHSVEIVGGSSRIPSVKQLIEQVFNKPASTTLNQDEAVSRGAALQCAIMSPAVRVRE 388
            .:.::.:|::|:|:|||.:|:|.||::|...|.|..|.||||||||:||.||.|||:||..||||
pombe   329 LAGIKKEDLYSIEMVGGCTRVPIVKEVIANYFGKGLSFTLNQDEAVARGCALSCAILSPVFRVRE 393

  Fly   389 FGVTDIQNYAVKVLWD--SEGSAAPGEIEIFPQYHASPFSRLLTINRKGPFNVSIVYGQQVPYP- 450
            |.|.|:..|.:...|:  .|.......:|:|.:.:..|.:::||..||.||.:...|.::...|
pombe   394 FHVHDVTTYPITFSWEPIPENPEEDSSLEVFSEGNPIPSTKILTFYRKAPFKLLAAYSKEAQLPG 458

  Fly   451 --DQTIGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAEEAAAAAEQAASEEK 513
              .|.|..:.:.||.|.:.|:...||:|||::.:||:::..|.:||::|.||....:.:..:|:|
pombe   459 SIKQNIAQYLINDVVPNKDGDLSIVKIKVRLDLHGILVVEQAYIVEEQEVEEPVETSPEEEAEKK 523

  Fly   514 PGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGSGADKKKKASKATELPL 578
                   |.||...:                                     |.||..|..:|.:
pombe   524 -------TDEPVKMR-------------------------------------KVKKLVKVADLSV 544

  Fly   579 ECTTHGFSPVDLSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQG--GPFERYVVEAE 641
            ...........|..|.:.|.:||..|:...|.:|.||||||::||.|.||..  .||..   |.|
pombe   545 SVQEDRLPTEVLEKYREAEHQMIATDKLVAETVDRKNALEEYIYDTRAKLDDIYAPFTN---EEE 606

  Fly   642 REKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPIKLRASDYEQGPAAFDELKNSIA-I 705
            ..|....|...|:||||:|||..:.:||::|:.|.:...||:.|..|.|:......:.:...| .
pombe   607 SSKFKEMLTKAEDWLYEEGEDTTKAVYTAKLEDLMRVGGPIRQRYLDAEEAKRQKVQAEREAAKA 671

  Fly   706 ARLAVAEFRKGVPKYDHLT 724
            |..:.||.:|...|::..|
pombe   672 ATKSEAEKQKPSGKFEEGT 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	174/381 (46%)
Hsc70Cb	NP_001189103.1	HSP70	3..682	CDD:278441	263/688 (38%)
pss1	NP_001342976.1	HSPA4_like_NDB	7..386	CDD:212670	174/380 (46%)
pss1	NP_001342976.1	Neuromodulin_N	<517..681	CDD:331332	56/210 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	456	1.000	Domainoid score	I67
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1624
Inparanoid	1	1.050	461	1.000	Inparanoid score	I282
OMA	1	1.010	-	-		QHG54058
OrthoFinder	1	1.000	-	-		FOG0001023
OrthoInspector	1	1.000	-	-		oto100449
orthoMCL	1	0.900	-	-		OOG6_100680
Panther	1	1.100	-	-	LDO	PTHR45639
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R574
SonicParanoid	1	1.000	-	-		X684
TreeFam	1	0.960	-	-
	14	13.860