DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70Cb and hspa4a

DIOPT Version :9

Sequence 1:	NP_001189103.1	Gene:	Hsc70Cb / 39557	FlyBaseID:	FBgn0026418	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_999881.1	Gene:	hspa4a / 335865	ZFINID:	ZDB-GENE-040426-2832	Length:	833	Species:	Danio rerio

Alignment Length:	847	Identity:	380/847 - (44%)
Similarity:	530/847 - (62%)	Gaps:	37/847 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVIGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVG 65
            |||:|.|.|.:|||||.||:|||||:||:||.|.|||||:|..:.|.||.|||:|.|||.||||.
Zfish     1 MSVVGFDVGFQSCYVAVARAGGIETVANEYSDRCTPSFVSFGPRNRSIGAAAKSQVVTNCKNTVQ 65

  Fly    66 GFKRLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSA 130
            ||||..||.|:||:|:...:|:...:....:|:.||||.|:.|::.||.||:||||.||||||:.
Zfish    66 GFKRFHGRAFSDPYVETTQSSLVYDLAQMPNGTTGIKVMYMEEEKLFGIEQVTAMLLTKLKETAE 130

  Fly   131 AAMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDL--FEDKP 193
            :|::..|.||||:.|.:||:|||::::|||||||||.|||||:|||.|||||.||.||  .|:||
Zfish   131 SALKKPVADCVISVPSYFTDAERRSVMDAAQIAGLNCLRLMNDTTAVALAYGIYKQDLPAPEEKP 195

  Fly   194 RNVIFVDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKTNA 257
            |.|:|||.||:..|.|||||.|||||:|.|.:| ::||:|.|..|..:|.:||.::||::.::..
Zfish   196 RTVVFVDVGHAGYQVSACAFNKGKLKVLGSAFDPELGGKDFDEVLVKHFCEEFAQKYKLDVRSKP 260

  Fly   258 RANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLL 322
            ||.:||..|.|||||.|||||:.||||||||::||||||.:.|::.|||||.:|.:||...:.::
Zfish   261 RALVRLYQECEKLKKLMSANSSDLPLNIECFMNDIDVSSKLNRAKFEELCAGLLAKVEAPLQSIM 325

  Fly   323 AESKLQLDDIHSVEIVGGSSRIPSVKQLIEQVFNKPASTTLNQDEAVSRGAALQCAIMSPAVRVR 387
            .:::|:.:||::|||:||:||||::|:.|.:.|.|..|||||.||||:||.||||||:|||.:||
Zfish   326 EQTRLKKEDIYAVEIIGGASRIPAIKERISKFFGKELSTTLNLDEAVARGCALQCAILSPAFKVR 390

  Fly   388 EFGVTDIQNYAVKVLWDSEGSAAPGEIEIFPQYHASPFSRLLTINRKGPFNVSIVYG--QQVPYP 450
            ||.:||:..|.:.:.|.|.......:.|:||:.||:|||::||..||.||.:...|.  :.:|||
Zfish   391 EFSITDVVPYPISLKWTSAADEGVSDCEVFPKNHAAPFSKVLTFYRKEPFTLEAYYNNPKALPYP 455

  Fly   451 DQTIGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVE---KKEAEEAAAAAEQAASEE 512
            |.|||.:.:..|.|...||...||:|||:|.:|:..:|||:|||   ..|.||.......|..||
Zfish   456 DPTIGQFTIHKVVPQASGESSKVKVKVRVNVHGVFSVSSASLVELLKPGEGEEPMETDTPAKDEE 520

  Fly   513 K--PGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGSGADKKKKASKATE 575
            .  ..||.....: ||.|:|...:..|..:..|  ||..:   |..|......|.|.|..:|..:
Zfish   521 NKMQVDQEAQKAQ-ADDQKEQADKKSDTEDMET--SPEDK---QEKKNDQPPQAKKAKVKTKTVD 579

  Fly   576 LPLECTTHGFSPVDLSN-YTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQGGPFERYVVE 639
            ||:..:.......|..| :.:.|.|||..|:.|.||.||||.:||:||:||:||. |..|.:|.|
Zfish   580 LPIMNSLQWQLASDALNLFMENEGKMIMQDKLEKERNDAKNYVEEYVYEMRDKLH-GVLENFVSE 643

  Fly   640 AEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPIKLRASDYEQGPAAFDELKNSIA 704
            |||:....:|.|.||||||:|||.::.:|..:|..|.:..|||:.|..:.|..|.||:||...|.
Zfish   644 AERDSFSLKLEDTENWLYEEGEDQQKQVYIDKLAELKKLGDPIQSRYIEAEVRPKAFEELGRQIQ 708

  Fly   705 IARLAVAEFRKGVPKYDHLTETEFINISETADKAQSWLDANLPKFTQSPRTADSPVQISAVRQEV 769
            :....|..|:.....||||.|.|.:.:.:..:.|.:|::..:...::...:.|..|::..::.:.
Zfish   709 LYMKVVEAFKAKDELYDHLDELEMVKVEKQVNDAMTWMNNKMNLQSKQSLSQDPAVKVQEIQTKT 773

  Fly   770 QTLNSCVSSVINRAKPKPTPAKTATPPKDEANAEQNGGEPAANSGDKMDVDNNGQSAAGNDPSME 834
            :.|.|..:.|:.::|||      ..|||:|..|||||  |.           |||..:...|...
Zfish   774 KELYSACNPVVTKSKPK------VEPPKEETAAEQNG--PV-----------NGQQPSDAQPEKS 819

  Fly   835 VE 836
            .|
Zfish   820 PE 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	217/381 (57%)
Hsc70Cb	NP_001189103.1	HSP70	3..682	CDD:278441	335/689 (49%)
hspa4a	NP_999881.1	NBD_sugar-kinase_HSP70_actin	2..384	CDD:302596	217/381 (57%)
hspa4a	NP_999881.1	HSP70	3..692	CDD:278441	338/695 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592212
Domainoid	1	1.000	614	1.000	Domainoid score	I182
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1624
Inparanoid	1	1.050	678	1.000	Inparanoid score	I694
OMA	1	1.010	-	-		QHG54058
OrthoDB	1	1.010	-	-		D285748at33208
OrthoFinder	1	1.000	-	-		FOG0001023
OrthoInspector	1	1.000	-	-		otm25120
orthoMCL	1	0.900	-	-		OOG6_100680
Panther	1	1.100	-	-	LDO	PTHR45639
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R574
SonicParanoid	1	1.000	-	-		X684
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800