DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70Cb and hspa4b

DIOPT Version :9

Sequence 1:	NP_001189103.1	Gene:	Hsc70Cb / 39557	FlyBaseID:	FBgn0026418	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_956151.1	Gene:	hspa4b / 334086	ZFINID:	ZDB-GENE-030131-6018	Length:	840	Species:	Danio rerio

Alignment Length:	853	Identity:	375/853 - (43%)
Similarity:	526/853 - (61%)	Gaps:	48/853 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVIGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVG 65
            |||:|.|.|..:||||.||:|||||:||:||.|.||:.|:|..:.|.||.|||:|.|||.||||.
Zfish     1 MSVVGFDVGFLNCYVAVARAGGIETVANEYSDRCTPACVSFGPRNRSIGAAAKSQMVTNCKNTVH 65

  Fly    66 GFKRLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSA 130
            ||||..||.|:||.||:...|:...:.....|:.|:||.|:.|::.|..||:||||.||||||:.
Zfish    66 GFKRFHGRAFSDPFVQNLKPSLVYDLAQMPSGTTGLKVMYMEEEKVFSIEQVTAMLLTKLKETAE 130

  Fly   131 AAMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDL--FEDKP 193
            :|::..|.||||:.|.|:|:|||::::|||||||||.|||||||||.|||||.||.||  .|:||
Zfish   131 SALKKPVADCVISVPCFYTDAERRSVIDAAQIAGLNCLRLMNETTAVALAYGIYKQDLPAPEEKP 195

  Fly   194 RNVIFVDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKTNA 257
            |||:|||.|||..|.|.|||.|||||:||:.:| ::||:..|..|..||.:||..:||::|||..
Zfish   196 RNVVFVDIGHSGYQVSVCAFNKGKLKILATAFDPEMGGKYFDERLVKYFCEEFVVKYKLDAKTKP 260

  Fly   258 RANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLL 322
            ||.:||..|.|||||.|||||:.||||||||::|:||||.:.|:|.||:||.:|.|||...:.||
Zfish   261 RALIRLFQECEKLKKLMSANSSDLPLNIECFMNDVDVSSRLNRAQFEEMCADILARVEPPLRSLL 325

  Fly   323 AESKLQLDDIHSVEIVGGSSRIPSVKQLIEQVFNKPASTTLNQDEAVSRGAALQCAIMSPAVRVR 387
            .::.|:.||||:||||||:||:|::|:.|.:.|.|..|||||.||||:||.||||||:|||.:||
Zfish   326 EQAHLKKDDIHAVEIVGGASRMPAIKERISKFFGKEPSTTLNADEAVARGCALQCAILSPAFKVR 390

  Fly   388 EFGVTDIQNYAVKVLWDSEGSAAPGEIEIFPQYHASPFSRLLTINRKGPFNVSIVYG--QQVPYP 450
            ||.:|::..:.:.:.|:|.......:.|:||:.||:|||::||..|:.||.:...|.  :::|||
Zfish   391 EFSITEVVPFPISLKWNSAAEDGVSDCEVFPKNHAAPFSKVLTFYRREPFTLDAYYNSPKELPYP 455

  Fly   451 DQTIGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVE--KKEAEEAAAAAEQAA---- 509
            |.|||.:.|:.|.|...||...||:|||:|.:||..:|||:|||  |.|.||.:...||:.
Zfish   456 DPTIGQYVVQKVVPQASGESSKVKVKVRVNIHGIFSVSSASLVEVQKSEEEEESMETEQSTEKEN 520

  Fly   510 --------SEEKPGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGSGADK 566
                    .|:|..:.....||...|.:|.....|:......:..|              ..|.|
Zfish   521 ENKMQVDQEEQKTPETEQENGEKKPGTEEMETSAEEGKQEKKSDQP--------------PQAKK 571

  Fly   567 KKKASKATELPLECTTHGFSPVDLSN-YTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQG 630
            .|..:|..:||:|.........|:.| :.:.|.|||..|:.|.||.||||.:||:||:||:||.
Zfish   572 PKVKTKVLDLPIENNPQWQLANDMLNLFVESEGKMIMQDKLEKERNDAKNYVEEYVYEMRDKLH- 635

  Fly   631 GPFERYVVEAEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPIKLRASDYEQGPAA 695
            |.||::|.|::|:.:..:|.|.|.||||||||..:.||..:|..|.....||:.|..::|:.|.|
Zfish   636 GIFEKFVTESDRDVLSLKLEDTEVWLYEDGEDQPKQIYIDKLAELKNLGQPIQDRYREFEERPKA 700

  Fly   696 FDELKNSIAIARLAVAEFRKGVPKYDHLTETEFINISETADKAQSWLDANLPKFTQSPRTADSPV 760
            |:||...:......|..::....:||||.|.|...:.:..:....|:::.:.:.::.....:..|
Zfish   701 FEELGRQLQQYMKIVEAYKTKEEQYDHLEEAEIQKVDKMVNDVMIWMNSKMNQQSKQSLAIEPVV 765

  Fly   761 QISAVRQEVQTLNSCVSSVINRAKPKPTPAKTATP--PKDEANAEQN------GGEPAA-----N 812
            :.:.::.:.:.|.|..:.|:.:.|||....|...|  |....|.::|      |.||||     |
Zfish   766 KTTEIQAKTRELFSTCNPVVTKPKPKVDLPKEENPSEPNGPVNTQENPEAQPGGTEPAAADSAGN 830

  Fly   813 SGDKMDVD 820
            :.:|.|:|
Zfish   831 TENKPDMD 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	222/381 (58%)
Hsc70Cb	NP_001189103.1	HSP70	3..682	CDD:278441	335/698 (48%)
hspa4b	NP_956151.1	HSPA4_NBD	2..384	CDD:212687	222/381 (58%)
hspa4b	NP_956151.1	HSP70	3..693	CDD:278441	338/704 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592211
Domainoid	1	1.000	614	1.000	Domainoid score	I182
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1624
Inparanoid	1	1.050	678	1.000	Inparanoid score	I694
OMA	1	1.010	-	-		QHG54058
OrthoDB	1	1.010	-	-		D285748at33208
OrthoFinder	1	1.000	-	-		FOG0001023
OrthoInspector	1	1.000	-	-		otm25120
orthoMCL	1	0.900	-	-		OOG6_100680
Panther	1	1.100	-	-	O	PTHR45639
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R574
SonicParanoid	1	1.000	-	-		X684
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800