DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsc70Cb and HSPA9

DIOPT Version :9

Sequence 1:NP_001189103.1 Gene:Hsc70Cb / 39557 FlyBaseID:FBgn0026418 Length:836 Species:Drosophila melanogaster
Sequence 2:NP_004125.3 Gene:HSPA9 / 3313 HGNCID:5244 Length:679 Species:Homo sapiens


Alignment Length:702 Identity:182/702 - (25%)
Similarity:310/702 - (44%) Gaps:141/702 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SVIGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAF--DGKKRIIGVAAKNQQVTNMKNTV 64
            :|:|||.|..:..||.......:.|.|....|.|||.|||  || :|::|:.||.|.|||..||.
Human    54 AVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADG-ERLVGMPAKRQAVTNPNNTF 117

  Fly    65 GGFKRLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETS 129
            ...|||:||:::||.||.::.::|.::....:|...::.:    .:.:.|.|:.|.:..|:|||:
Human   118 YATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAH----GKLYSPSQIGAFVLMKMKETA 178

  Fly   130 AAAMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDLFEDKPR 194
            ...:.....:.||..|.:|.:::|:|..||.||:||||||::||.||.|||||..|:   |||  
Human   179 ENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKS---EDK-- 238

  Fly   195 NVIFV-DFGHSSLQASACAFTKGKLKMLASTWDQ-IGGRDIDLALGDYFAKEFQERYKINAKTNA 257
             ||.| |.|..:...|.....||..::.::..|. :||.|.|.||..:..|||:....::...:.
Human   239 -VIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDN 302

  Fly   258 RANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDID----VSSSMQRSQMEELCAPVLQRVEQTF 318
            .|..|:....||.|.::| :|.:..:|:.....|..    ::..:.|:|.|.:...:::|.....
Human   303 MALQRVREAAEKAKCELS-SSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPC 366

  Fly   319 KRLLAESKLQLDDIHSVEIVGGSSRIPSVKQLIEQVFNKPASTTLNQDEAVSRGAALQCAIMSPA 383
            ::.:.::::...||..|.:|||.:|:|.|:|.::.:|.:..|..:|.||||:.|||:|..:::. 
Human   367 QKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAG- 430

  Fly   384 VRVREFGVTDIQNYAVKVLWDSEGSAAPGEIEIFPQYHASPFSRLLTINRKGPFNVSIVY----- 443
                  .|||:....|..|  |.|....|.:          |::|:..|...|...|.|:     
Human   431 ------DVTDVLLLDVTPL--SLGIETLGGV----------FTKLINRNTTIPTKKSQVFSTAAD 477

  Fly   444 GQ------------QVPYPDQTIGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKK 496
            ||            ::...::.:|.:.:..:.|..||..| :::...|:.||||.:|        
Human   478 GQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQ-IEVTFDIDANGIVHVS-------- 533

  Fly   497 EAEEAAAAAEQAASEEKPGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFG 561
             |::.....||....:..|                                              
Human   534 -AKDKGTGREQQIVIQSSG---------------------------------------------- 551

  Fly   562 SGADKKKKASKATELPLECTTHGFSPVDLSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRN 626
                                  |.|..|:.|..:...|....|:::.||::|.|..|..::|...
Human   552 ----------------------GLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTET 594

  Fly   627 KLQGGPFERYVVEAEREKIVSQLNDLENWL----YEDGEDCERDIYTSRLQA 674
            |::  .|:..:...|..|:..:::.:...|    .|.||:. |...:|..||
Human   595 KME--EFKDQLPADECNKLKEEISKMRELLARKDSETGENI-RQAASSLQQA 643

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsc70CbNP_001189103.1 HSPA4_like_NDB 2..381 CDD:212670 127/386 (33%)
HSP70 3..682 CDD:278441 182/701 (26%)
HSPA9NP_004125.3 Interaction with NFS1. /evidence=ECO:0000269|PubMed:26702583 1..432 127/396 (32%)
dnaK 52..673 CDD:234715 182/702 (26%)
Interaction with FXN and ISCU. /evidence=ECO:0000269|PubMed:26702583 432..679 55/305 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 656..679
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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