DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70Cb and HSPA8

DIOPT Version :9

Sequence 1:	NP_001189103.1	Gene:	Hsc70Cb / 39557	FlyBaseID:	FBgn0026418	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_006588.1	Gene:	HSPA8 / 3312	HGNCID:	5241	Length:	646	Species:	Homo sapiens

Alignment Length:	690	Identity:	190/690 - (27%)
Similarity:	338/690 - (48%)	Gaps:	101/690 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVGGFK 68
            :|||.|.....|...:.|.:|.:|||...|.|||:|||...:|:||.|||||...|..|||...|
Human     7 VGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFDAK 71

  Fly    69 RLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSAAAM 133
            ||:||:|:|..||.::...|..| ....|...::|.|.||.:.|.||::::|:.||:||.:.|.:
Human    72 RLIGRRFDDAVVQSDMKHWPFMV-VNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAYL 135

  Fly   134 QTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDLFEDKPRNVIF 198
            ...|.:.|:..|.:|.:::|:|..||..||||||||::||.||.|:|||..|....|   |||:.
Human   136 GKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAE---RNVLI 197

  Fly   199 VDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKTNARANLR 262
            .|.|..:...|......|..::.::..| .:||.|.|..:.::|..||:.::|.:...|.||..|
Human   198 FDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRR 262

  Fly   263 LLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLLAESKL 327
            |.|..|:.|:.:| :||:..:.|:...:.||..:|:.|::.|||.|.:.:......::.|.::||
Human   263 LRTACERAKRTLS-SSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKL 326

  Fly   328 QLDDIHSVEIVGGSSRIPSVKQLIEQVFN-KPASTTLNQDEAVSRGAALQCAIMS--PAVRVREF 389
            ....||.:.:||||:|||.:::|::..|| |..:.::|.||||:.|||:|.||:|  .:..|::.
Human   327 DKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDL 391

  Fly   390 GVTDIQNYAVKVLWDSEGSAAPGEIEIFPQYHAS-PFSRLLTI-----NRKGPFNVSIVYGQQVP 448
            .:.|:...::.:      ..|.|.:.:..:.:.: |..:..|.     |:.|.. :.:..|::..
Human   392 LLLDVTPLSLGI------ETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVL-IQVYEGERAM 449

  Fly   449 YPDQT-IGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAEEAAAAAEQAASEE 512
            ..|.. :|.:::..:.|..||..| :::...|:.|||:.:|               |.:::..:|
Human   450 TKDNNLLGKFELTGIPPAPRGVPQ-IEVTFDIDANGILNVS---------------AVDKSTGKE 498

  Fly   513 KPGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGSGADKKKKASKATELP 577
            .....||:.|.
Human   499 NKITITNDKGR------------------------------------------------------ 509

  Fly   578 LECTTHGFSPVDLSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQGGPFERYVVEAER 642
                   .|..|:....|:..|....|:|:.:::.:||:||.:.::|:..::....:..:.:.::
Human   510 -------LSKEDIERMVQEAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDK 567

  Fly   643 EKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPI 682
            :||:.:.|::.||| :..:..|::.:..:.:.|.:..:||
Human   568 QKILDKCNEIINWL-DKNQTAEKEEFEHQQKELEKVCNPI 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	143/378 (38%)
Hsc70Cb	NP_001189103.1	HSP70	3..682	CDD:278441	188/688 (27%)
HSPA8	NP_006588.1	PTZ00009	1..613	CDD:240227	190/690 (28%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000305\|PubMed:27474739	2..386		144/383 (38%)
		Interaction with BAG1	186..377		62/194 (32%)
		Substrate-binding domain (SBD). /evidence=ECO:0000305\|PubMed:27474739	394..509		23/137 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	614..646
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156586
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740