DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70Cb and HSPA5

DIOPT Version :9

Sequence 1:	NP_001189103.1	Gene:	Hsc70Cb / 39557	FlyBaseID:	FBgn0026418	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_005338.1	Gene:	HSPA5 / 3309	HGNCID:	5238	Length:	654	Species:	Homo sapiens

Alignment Length:	717	Identity:	195/717 - (27%)
Similarity:	342/717 - (47%)	Gaps:	110/717 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SVIGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGK-KRIIGVAAKNQQVTNMKNTVG 65
            :|:|||.|.....|...::|.:|.:|||...|.|||:|||..: :|:||.|||||..:|.:|||.
Human    29 TVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVF 93

  Fly    66 GFKRLLGRKFNDPHVQHELTSIPAR-VEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETS 129
            ..|||:||.:|||.||.::..:|.: ||.:....|.:.:.. |:.:.|.||:::||:.||:|||:
Human    94 DAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGG-GQTKTFAPEEISAMVLTKMKETA 157

  Fly   130 AAAMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDLFEDKPR 194
            .|.:..:|...|:..|.:|.:|:|:|..||..||||||:|::||.||.|:|||..|    .:..:
Human   158 EAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDK----REGEK 218

  Fly   195 NVIFVDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKTNAR 258
            |::..|.|..:...|......|..:::|:..| .:||.|.|..:.::|.|.::::...:.:.:.|
Human   219 NILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNR 283

  Fly   259 ANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLLA 323
            |..:|..|:||.|:.:|:.. :..:.||.|.:..|.|.::.|::.|||...:.:...:..:::|.
Human   284 AVQKLRREVEKAKRALSSQH-QARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLE 347

  Fly   324 ESKLQLDDIHSVEIVGGSSRIPSVKQLIEQVFN-KPASTTLNQDEAVSRGAALQCAIMSPAVRVR 387
            :|.|:..||..:.:||||:|||.::||:::.|| |..|..:|.||||:.|||:|..::|......
Human   348 DSDLKKSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTG 412

  Fly   388 EFGVTDIQNYAVKVLWDSEGSAAPGEI---EIFPQYHASPFSRLLTINRKGPFNVSIVYGQQVPY 449
            :..:.|:....:.:  ::.|......|   .:.|...:..||   |.:...|.....||..:.|.
Human   413 DLVLLDVCPLTLGI--ETVGGVMTKLIPRNTVVPTKKSQIFS---TASDNQPTVTIKVYEGERPL 472

  Fly   450 --PDQTIGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAEEAAAAAEQAASEE 512
              .:..:|.:.:..:.|..||..| :::...|:.|||:.::                     :|:
Human   473 TKDNHLLGTFDLTGIPPAPRGVPQ-IEVTFEIDVNGILRVT---------------------AED 515

  Fly   513 KPGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGSGADKKKKASKATELP 577
            |                                                 |...|.|.:...:
Human   516 K-------------------------------------------------GTGNKNKITITND-- 529

  Fly   578 LECTTHGFSPVDLSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQGGPFERY---VVE 639
                .:..:|.::........|....|:|..||||.:|.||.:.|.::|::  |..|:.   :..
Human   530 ----QNRLTPEEIERMVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQI--GDKEKLGGKLSS 588

  Fly   640 AEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPI--KLRAS-----DYEQGPAAFD 697
            .::|.:...:.:...|| |..:|.:.:.:.::.:.|.:...||  ||..|     ..|:..|..|
Human   589 EDKETMEKAVEEKIEWL-ESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGEEDTAEKD 652

  Fly   698 EL 699
            ||
Human   653 EL 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	138/382 (36%)
Hsc70Cb	NP_001189103.1	HSP70	3..682	CDD:278441	185/690 (27%)
HSPA5	NP_005338.1	Required for interaction with KIAA1324. /evidence=ECO:0000269\|PubMed:26045166	1..80		21/50 (42%)
		HSP70	30..635	CDD:394970	188/695 (27%)
		Nucleotide-binding (NBD). /evidence=ECO:0000303\|PubMed:28286085	125..280		51/159 (32%)
		Interdomain linker. /evidence=ECO:0000250\|UniProtKB:G3I8R9	409..419		0/9 (0%)
		Substrate-binding (SBD). /evidence=ECO:0000303\|PubMed:28286085	420..500		15/85 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	633..654		6/20 (30%)
		Prevents secretion from ER. /evidence=ECO:0000255	651..654		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810