DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70Cb and HSPA4

DIOPT Version :9

Sequence 1:	NP_001189103.1	Gene:	Hsc70Cb / 39557	FlyBaseID:	FBgn0026418	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_002145.3	Gene:	HSPA4 / 3308	HGNCID:	5237	Length:	840	Species:	Homo sapiens

Alignment Length:	869	Identity:	375/869 - (43%)
Similarity:	529/869 - (60%)	Gaps:	62/869 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVIGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVG 65
            |||:|||.|.:|||||.||:|||||:||:||.|.||:.::|..|.|.||.|||:|.::|.||||.
Human     1 MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACISFGPKNRSIGAAAKSQVISNAKNTVQ 65

  Fly    66 GFKRLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSA 130
            ||||..||.|:||.|:.|.:::...:.....|..||||.|:.|:::|..||:||||.:|||||:.
Human    66 GFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAMLLSKLKETAE 130

  Fly   131 AAMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDL--FEDKP 193
            :.::..|.|||::.|.|:|:|||::::||.||||||.|||||||||.|||||.||.||  .|:||
Human   131 SVLKKPVVDCVVSVPCFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKP 195

  Fly   194 RNVIFVDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKTNA 257
            |||:|||.|||:.|.|.|||.:||||:||:.:| .:|||..|..|.::|.:||.::||::.|:..
Human   196 RNVVFVDMGHSAYQVSVCAFNRGKLKVLATAFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSKI 260

  Fly   258 RANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLL 322
            ||.|||..|.|||||.||||::.|||:||||::|:|||.:|.|.:..|:|..:|.|||...:.:|
Human   261 RALLRLSQECEKLKKLMSANASDLPLSIECFMNDVDVSGTMNRGKFLEMCNDLLARVEPPLRSVL 325

  Fly   323 AESKLQLDDIHSVEIVGGSSRIPSVKQLIEQVFNKPASTTLNQDEAVSRGAALQCAIMSPAVRVR 387
            .::||:.:||::||||||::|||:||:.|.:.|.|..|||||.||||:||.||||||:|||.:||
Human   326 EQTKLKKEDIYAVEIVGGATRIPAVKEKISKFFGKELSTTLNADEAVTRGCALQCAILSPAFKVR 390

  Fly   388 EFGVTDIQNYAVKVLWDSEGSAAPGEIEIFPQYHASPFSRLLTINRKGPFNVSIVYG--QQVPYP 450
            ||.:||:..|.:.:.|:|.......:.|:|.:.||:|||::||..||.||.:...|.  |.:|||
Human   391 EFSITDVVPYPISLRWNSPAEEGSSDCEVFSKNHAAPFSKVLTFYRKEPFTLEAYYSSPQDLPYP 455

  Fly   451 DQTIGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVE--KKEAEEAAAAAEQAASEEK 513
            |..|..:.|:.|.|...|....||:|||:|.:||..:|||:|||  |.|..|.....:|.|.||:
Human   456 DPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSASLVEVHKSEENEEPMETDQNAKEEE 520

  Fly   514 PGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGSGADKK-------KKAS 571
            ............:.||:...||:.::.....|..|.:              |||       |||.
Human   521 KMQVDQEEPHVEEQQQQTPAENKAESEEMETSQAGSK--------------DKKMDQPPQAKKAK 571

  Fly   572 KAT---ELPLECTTHGFSPVD---LSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQG 630
            ..|   :||:|  ......:|   |:.|.:.|.|||..|:.|.||.|||||:||:||:||:|| .
Human   572 VKTSTVDLPIE--NQLLWQIDREMLNLYIENEGKMIMQDKLEKERNDAKNAVEEYVYEMRDKL-S 633

  Fly   631 GPFERYVVEAEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPIKLRASDYEQGPAA 695
            |.:|::|.|.:|.....:|.|.||||||||||..:.:|..:|..|.....|||:|..:.|:.|..
Human   634 GEYEKFVSEDDRNSFTLKLEDTENWLYEDGEDQPKQVYVDKLAELKNLGQPIKIRFQESEERPKL 698

  Fly   696 FDELKNSIAIARLAVAEFRKGVPKYDHLTETEFINISETADKAQSWLDANLPKFTQSPRTADSPV 760
            |:||...|......::.|:....:||||...:...:.::.::|..|::..|....:...|.|..|
Human   699 FEELGKQIQQYMKIISSFKNKEDQYDHLDAADMTKVEKSTNEAMEWMNNKLNLQNKQSLTMDPVV 763

  Fly   761 QISAVRQEVQTLNSCVSSVINRAKPKPTPAKTATPPKDEANAEQNGGEPAANSGDKMDVDNNGQS 825
            :...:..:::.|.|..|.:|::.|||..|     |.:::.||||||  |....|     ||.|..
Human   764 KSKEIEAKIKELTSTCSPIISKPKPKVEP-----PKEEQKNAEQNG--PVDGQG-----DNPGPQ 816

  Fly   826 AA--GND-----------PSMEVE 836
            ||  |.|           |.|:::
Human   817 AAEQGTDTAVPSDSDKKLPEMDID 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	210/381 (55%)
Hsc70Cb	NP_001189103.1	HSP70	3..682	CDD:278441	326/698 (47%)
HSPA4	NP_002145.3	HSPA4_NBD	2..384	CDD:212687	210/381 (55%)
		HSP70	3..607	CDD:278441	289/619 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..575		19/88 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	779..840		24/72 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156591
Domainoid	1	1.000	603	1.000	Domainoid score	I195
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1624
Inparanoid	1	1.050	671	1.000	Inparanoid score	I739
Isobase	1	0.950	-	0	Normalized mean entropy	S1071
OMA	1	1.010	-	-		QHG54058
OrthoDB	1	1.010	-	-		D285748at33208
OrthoFinder	1	1.000	-	-		FOG0001023
OrthoInspector	1	1.000	-	-		otm40306
orthoMCL	1	0.900	-	-		OOG6_100680
Panther	1	1.100	-	-	LDO	PTHR45639
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R574
SonicParanoid	1	1.000	-	-		X684
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750