Protein Alignment Hsp110 and HSPA2

DIOPT Version :10

• Sequence 1: NP_001189103.1
• Gene: Hsp110 / 39557
• FlyBaseID: FBgn0026418
• Length: 836
• Species: Drosophila melanogaster
• Sequence 2: NP_068814.2
• Gene: HSPA2 / 3306
• HGNCID: 5235
• Length: 639
• Species: Homo sapiens
• Alignment Length: 706
• Identity: 196/706 - (27%)
• Similarity: 336/706 - (47%)
• Gaps: 111/706 - (15%)

  Fly     4 IGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVGGFK 68
            ||||.|.....|...:.|.:|.:|||...|.|||:|||...:|:||.|||||...|..||:...|
Human     8 IGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTIFDAK 72

  Fly    69 RLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSAAAM 133
            ||:||||.|..||.::...|.||.:.| |...::|.|.||.:.|.||::::|:.||:||.:.|.:
Human    73 RLIGRKFEDATVQSDMKHWPFRVVSEG-GKPKVQVEYKGETKTFFPEEISSMVLTKMKEIAEAYL 136

  Fly   134 QTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDLFEDKPRNVIF 198
            ..:|:..||..|.:|.:::|:|..||..|.||||||::||.||.|:|||..|......: :||:.
Human   137 GGKVHSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGE-KNVLI 200

  Fly   199 VDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKTNARANLR 262
            .|.|..:...|......|..::.::..| .:||.|.|..:..:.|:||:.::|.:...|.||..|
Human   201 FDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRAVRR 265

  Fly   263 LLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLLAESKL 327
            |.|..|:.|:.:| :||:..:.|:...:.:|..:|:.|::.|||.|.:.:...:..::.|.::||
Human   266 LRTACERAKRTLS-SSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDAKL 329

  Fly   328 QLDDIHSVEIVGGSSRIPSVKQLIEQVFN-KPASTTLNQDEAVSRGAALQCAIM--SPAVRVREF 389
            ....|..:.:||||:|||.:::|::..|| |..:.::|.||||:.|||:|.||:  ..:..|::.
Human   330 DKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQDL 394

  Fly   390 GVTDIQNYAVKV---------LWDSEGSAAPGEIEIFPQYHASPFSRLLTINRKGPFNVSIVYGQ 445
            .:.|:...::.:         |.....:....:.:.|..|..:..|.|          |.:..|:
Human   395 LLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVL----------VQVYEGE 449

  Fly   446 QVPYPDQT-IGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAEEAAAAAEQAA 509
            :....|.. :|.:.:..:.|..||..| :::...|:.|||:.::               ||:::.
Human   450 RAMTKDNNLLGKFDLTGIPPAPRGVPQ-IEVTFDIDANGILNVT---------------AADKST 498

  Fly   510 SEEKPGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGSGADKKKKASKAT 574
            .:|.....||:.|.
Human   499 GKENKITITNDKGR--------------------------------------------------- 512

  Fly   575 ELPLECTTHGFSPVDLSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQGGPFERYVVE 639
                      .|..|:....|:..:....|:...:|:.||||||.:.|:::..::.......:.|
Human   513 ----------LSKDDIDRMVQEAERYKSEDEANRDRVAAKNALESYTYNIKQTVEDEKLRGKISE 567

  Fly   640 AEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPI--KLRASDYEQGP 693
            .::.||:.:..::.||| :..:..|:|.|..:.:.|.:..:||  ||    |:.||
Human   568 QDKNKILDKCQEVINWL-DRNQMAEKDEYEHKQKELERVCNPIISKL----YQGGP 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp110	NP_001189103.1	ASKHA_NBD_HSP70_HSPA4_like	4..378	CDD:466826	140/375 (37%)
HSPA2	NP_068814.2	PTZ00009	2..615	CDD:240227	193/701 (28%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	2..389		142/383 (37%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	397..512		23/140 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	613..639		4/10 (40%)