DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70Cb and HSPA1L

DIOPT Version :9

Sequence 1:	NP_001189103.1	Gene:	Hsc70Cb / 39557	FlyBaseID:	FBgn0026418	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_005518.3	Gene:	HSPA1L / 3305	HGNCID:	5234	Length:	641	Species:	Homo sapiens

Alignment Length:	710	Identity:	212/710 - (29%)
Similarity:	344/710 - (48%)	Gaps:	116/710 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVGGFK 68
            ||||.|.....|...:.|.:|.:|||...|.|||:|||...:|:||.|||||...|.:|||...|
Human     9 IGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPQNTVFDAK 73

  Fly    69 RLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSAAAM 133
            ||:|||||||.||.::...|.:|...| |...:.|:|.||::.|.||::::|:.||||||:.|.:
Human    74 RLIGRKFNDPVVQADMKLWPFQVINEG-GKPKVLVSYKGENKAFYPEEISSMVLTKLKETAEAFL 137

  Fly   134 QTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDLFEDKPRNVIF 198
            ...|.:.||..|.:|.:::|:|..||..||||||||::||.||.|:|||..|....|   |:|:.
Human   138 GHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGGQGE---RHVLI 199

  Fly   199 VDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKTNARANLR 262
            .|.|..:...|......|..::.|:..| .:||.|.|..|..:|.:||:.::|.:...|.||..|
Human   200 FDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRR 264

  Fly   263 LLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLLAESKL 327
            |.|..|:.|:.:| :||:..|.|:...:.||..:|:.|::.|||||.:.:...:..::.|.::|:
Human   265 LRTACERAKRTLS-SSTQANLEIDSLYEGIDFYTSITRARFEELCADLFRGTLEPVEKALRDAKM 328

  Fly   328 QLDDIHSVEIVGGSSRIPSVKQLIEQVFN-KPASTTLNQDEAVSRGAALQCAIM--SPAVRVREF 389
            ....||.:.:||||:|||.|::|::..|| :..:.::|.||||:.|||:|.||:  ..:.:|::.
Human   329 DKAKIHDIVLVGGSTRIPKVQRLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSEKVQDL 393

  Fly   390 GVTDIQNYA--------VKVLWDSEGSAAP-GEIEIFPQYHASPFSRLLTINRKGPFNVSIVYGQ 445
            .:.|:...:        |........|..| .:.:||..|         :.|:.|.. :.:..|:
Human   394 LLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTY---------SDNQPGVL-IQVYEGE 448

  Fly   446 QVPYPDQT-IGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAEEAAAAAEQAA 509
            :....|.. :|.:.:..:.|..||..| :::...|:.|||:
Human   449 RAMTKDNNLLGRFDLTGIPPAPRGVPQ-IEVTFDIDANGIL------------------------ 488

  Fly   510 SEEKPGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGSGADKKKKASKAT 574
                                         |.|:|..|.|                       |..
Human   489 -----------------------------NVTATDKSTG-----------------------KVN 501

  Fly   575 ELPLECTTHGFSPVDLSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQGGPFERYVVE 639
            ::.:.......|..::........|....|:.:.|:|.||||||.:.::|::.:.....:..:.|
Human   502 KITITNDKGRLSKEEIERMVLDAEKYKAEDEVQREKIAAKNALESYAFNMKSVVSDEGLKGKISE 566

  Fly   640 AEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPI--KLRASDYE---QGPA 694
            :::.||:.:.|:|.:|| |..:..|:|.:..:.:.|.|..:||  ||    |:   .|||
Human   567 SDKNKILDKCNELLSWL-EVNQLAEKDEFDHKRKELEQMCNPIITKL----YQGGCTGPA 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	153/380 (40%)
Hsc70Cb	NP_001189103.1	HSP70	3..682	CDD:278441	204/691 (30%)
HSPA1L	NP_005518.3	Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	3..388		153/383 (40%)
		HSP70	4..641	CDD:331774	212/710 (30%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	396..511		26/201 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156587
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740