DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsc70Cb and HSPA1B

DIOPT Version :9

Sequence 1:NP_001189103.1 Gene:Hsc70Cb / 39557 FlyBaseID:FBgn0026418 Length:836 Species:Drosophila melanogaster
Sequence 2:NP_005337.2 Gene:HSPA1B / 3304 HGNCID:5233 Length:641 Species:Homo sapiens


Alignment Length:695 Identity:202/695 - (29%)
Similarity:340/695 - (48%) Gaps:107/695 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SVIGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVGG 66
            :.||||.|.....|...:.|.:|.:|||...|.|||:|||...:|:||.|||||...|.:|||..
Human     5 AAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFD 69

  Fly    67 FKRLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSAA 131
            .|||:||||.||.||.::...|.:|...|| ...::|:|.||.:.|.||::::|:.||:||.:.|
Human    70 AKRLIGRKFGDPVVQSDMKHWPFQVINDGD-KPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEA 133

  Fly   132 AMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDLFEDKPRNV 196
            .:...|.:.||..|.:|.:::|:|..||..||||||||::||.||.|:|||..:....|   |||
Human   134 YLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGE---RNV 195

  Fly   197 IFVDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKTNARAN 260
            :..|.|..:...|......|..::.|:..| .:||.|.|..|.::|.:||:.::|.:...|.||.
Human   196 LIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAV 260

  Fly   261 LRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLLAES 325
            .||.|..|:.|:.:| :||:..|.|:...:.||..:|:.|::.||||:.:.:...:..::.|.::
Human   261 RRLRTACERAKRTLS-SSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDA 324

  Fly   326 KLQLDDIHSVEIVGGSSRIPSVKQLIEQVFN-KPASTTLNQDEAVSRGAALQCAIM--SPAVRVR 387
            ||....||.:.:||||:|||.|::|::..|| :..:.::|.||||:.|||:|.||:  ..:..|:
Human   325 KLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQ 389

  Fly   388 EFGVTDIQNYA--------VKVLWDSEGSAAP-GEIEIFPQYHASPFSRLLTINRKGPFNVSIVY 443
            :..:.|:...:        |........|..| .:.:||..|         :.|:.|.. :.:..
Human   390 DLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTY---------SDNQPGVL-IQVYE 444

  Fly   444 GQQVPYPDQT-IGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAEEAAAAAEQ 507
            |::....|.. :|.:::..:.|..||..| :::...|:.|||:                      
Human   445 GERAMTKDNNLLGRFELSGIPPAPRGVPQ-IEVTFDIDANGIL---------------------- 486

  Fly   508 AASEEKPGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGSGADKKKKASK 572
                                           |.|:|..|.|                       |
Human   487 -------------------------------NVTATDKSTG-----------------------K 497

  Fly   573 ATELPLECTTHGFSPVDLSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQGGPFERYV 637
            |.::.:.......|..::....|:..|....|:.:.||:.||||||.:.::|::.::....:..:
Human   498 ANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKI 562

  Fly   638 VEAEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPI 682
            .||:::|::.:..::.:|| :.....|:|.:..:.:.|.|..:||
Human   563 SEADKKKVLDKCQEVISWL-DANTLAEKDEFEHKRKELEQVCNPI 606

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsc70CbNP_001189103.1 HSPA4_like_NDB 2..381 CDD:212670 150/382 (39%)
HSP70 3..682 CDD:278441 200/692 (29%)
HSPA1BNP_005337.2 PTZ00009 1..611 CDD:240227 202/695 (29%)
Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142 2..386 150/385 (39%)
Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142 394..509 27/201 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 614..641
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165156585
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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