DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70Cb and hyou1

DIOPT Version :9

Sequence 1:	NP_001189103.1	Gene:	Hsc70Cb / 39557	FlyBaseID:	FBgn0026418	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_997868.1	Gene:	hyou1 / 327133	ZFINID:	ZDB-GENE-030131-5344	Length:	980	Species:	Danio rerio

Alignment Length:	976	Identity:	244/976 - (25%)
Similarity:	428/976 - (43%)	Gaps:	179/976 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVIGIDFGNESCYVAAARSG-GIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTV 64
            ::|:.:|.|:|...||..:.| .:|.:.|..|.|.||..|.....:|:.|..|....|.|.|...
Zfish    25 VAVMSVDLGSEWMKVAIVKPGVPMEIVLNKESRRKTPVAVCLKENERLFGDGALGVAVKNPKVVY 89

  Fly    65 GGFKRLLGRKFNDPHV--------QHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAML 121
            ...:.:||:..::|.|        :|:|.....|      |::..|   ..|:..:.||:|..|:
Zfish    90 RFLQSILGKTADNPQVAEYQKHFPEHQLQKDEKR------GTVYFK---FSEEMQYTPEELLGMI 145

  Fly   122 FTKLKETSAAAMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKN 186
            ....:..:....:..:.|.||..|.:|..|||:|:|.||.||||.||:|:|:.||.||.||.::.
Zfish   146 LNYSRTLAQDFAEQPIKDAVITVPAYFNQAERRAVLQAAHIAGLKVLQLINDNTAVALNYGVFRR 210

  Fly   187 DLFEDKPRNVIFVDFGHSSLQASACAF---------TKGKLKMLASTWDQ-IGGRDIDLALGDYF 241
            .......:|::|.|.|..|..|:...:         |:.:|::....:|: :||.:::|.|.|:.
Zfish   211 KDINSTAQNIMFYDMGSGSTTATIVTYQTVKTKESGTQPQLQIRGVGFDRTLGGFEMELRLRDHL 275

  Fly   242 AKEF--QERYKINAKTNARANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQME 304
            ||.|  |::.|.:.:.|.||..:||.|.::||..:|||: :....||..:||||..:.:.||:.|
Zfish   276 AKLFNEQKKSKKDVRDNLRAMAKLLKEAQRLKTVLSANA-EHTAQIEGLMDDIDFKAKVTRSEFE 339

  Fly   305 ELCAPVLQRVEQTFKRLLAESKLQLDDIHSVEIVGGSSRIPSVKQ-LIEQVFNKPASTTLNQDEA 368
            .||..:..||....|:.||.:::.:|:|..|.:|||::|:|.|:. |::.|..:..|..:|.|||
Zfish   340 ALCEDLFDRVPGPVKQALAAAEMSMDEIEQVILVGGATRVPKVQDVLLKSVGKEELSKNINADEA 404

  Fly   369 VSRGAALQCAIMSPAVRVREFGVTDIQNYAVKVLWDSEGSAAPG-------EIEIFPQYHASPFS 426
            .:.||..|.|.:|.|.:|:.|.|.|...:.::|.:..|.....|       :..:|.:....|..
Zfish   405 AAMGAVYQAAALSKAFKVKPFLVRDAAVFPIQVEFSRETEEEDGVKSLKHNKRILFQRMAPYPQR 469

  Fly   427 RLLTINRK-GPFNVSIVYGQQVPYPDQTIGVW--------KVKDV----KPTERGEGQDVKLKVR 478
            :::|.||. ..|...|.||......:|.:.|:        |:..|    |.....|.:.:|....
Zfish   470 KVITFNRYIDDFVFYINYGDLSFLSEQDMKVFGSQNLTTVKLSGVGSSFKKHSDAESKGIKAHFN 534

  Fly   479 INNNGIVLISSA-----TLVEKKEAEE-------------AAAAAEQAASEEKP-GDQTNNTGEP 524
            ::.:|::::...     |:||:||.|.             ...::|.:|:..:| .|:...|  |
Zfish   535 MDESGVLILDRVESVFETIVEEKEEESTLTKLGNTISSLFGGGSSEPSANVTEPVTDEEEVT--P 597

  Fly   525 ADGQQEAYCENEDD---NNTSTASSPGGQGWAQRVKGWFGSGADKKKKA-------SKATELPLE 579
            ..|:::...|.:::   ....|......:..|:..|       :.|:||       |:.||.|.|
Zfish   598 EAGKEQDQPEKQEETVQEKPETEEGKEAEPQAEEQK-------EDKEKAENQGETESEKTEKPEE 655

  Fly   580 CTTHGFSPVDLSNYTQQESK-------------------------------MIGNDQKETERIDA 613
            .||......|:....|::||                               :...|.::.||...
Zfish   656 KTTDEEKEADMKPKLQKKSKISADIAVELEVNDVLDPSAEDMEGSKKKLQDLTDRDLEKQEREKT 720

  Fly   614 KNALEEFVYDMRNKLQGGPFERYVVEAEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQK 678
            .|:||.|:::.::||....::..|.|.|:|:|..:|:...:|:.|:|......:...:|..|.:.
Zfish   721 LNSLEAFIFETQDKLYQDEYQAVVTEEEKEQISGRLSVASSWMDEEGYRAGTKLLKEKLSELKKL 785

  Fly   679 TDPIKLRASDYEQGP---AAFDELKNSIAI----ARLAVAEFRKGVPKYDHL-TETEFINISETA 735
            ...:..|..:.::.|   ||.|.:.|...|    |||        :|:.|.: |:.|...:.:..
Zfish   786 CKGMFFRVEERKKWPDRLAALDSMLNHSNIFLKSARL--------IPESDQIFTDVELKTLEKVI 842

  Fly   736 DKAQSWLDANLPKFTQSPRTADSPVQISA-VRQEVQTLNSCVSSVINR---AKPKP--------- 787
            ::..:|.:..:.:..:...|. .||.:|. :..::..|:..|:.::|:   |||||
Zfish   843 NETITWKNETVAEQEKLSPTV-KPVLLSKDIEAKLSLLDREVNYLLNKAKFAKPKPKDKAKDKNS 906

  Fly   788 ----------TPAKTATPPKDEANA------------EQNGGE------PAANSGDKMDVDNNGQ 824
                      ..|:...|||.|..|            |:...|      ||.|:.||.:...:.:
Zfish   907 TSESSKANSTDDAEKVIPPKTEDGAEKVKPAEEPPVVEEKAEETILELNPAENTDDKTESTESSK 971

  Fly   825 S 825
            |
Zfish   972 S 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	126/400 (32%)
Hsc70Cb	NP_001189103.1	HSP70	3..682	CDD:278441	203/780 (26%)
hyou1	NP_997868.1	HSP70	27..705	CDD:278441	183/696 (26%)
		HYOU1-like_NBD	28..414	CDD:212672	124/395 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	558..682		27/132 (20%)
		PTPRCAP	<598..>648	CDD:292341	8/56 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	894..980		18/79 (23%)
		Prevents secretion from ER. /evidence=ECO:0000255	977..980
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810