DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70Cb and Hspa4l

DIOPT Version :9

Sequence 1:	NP_001189103.1	Gene:	Hsc70Cb / 39557	FlyBaseID:	FBgn0026418	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_001099898.2	Gene:	Hspa4l / 294993	RGDID:	1306528	Length:	838	Species:	Rattus norvegicus

Alignment Length:	858	Identity:	368/858 - (42%)
Similarity:	535/858 - (62%)	Gaps:	42/858 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVIGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVG 65
            |||:|||.|..:||:|.||||||||:||:||.|.||:.::...:.|.||.|||:|.|||::||:.
  Rat     1 MSVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNVRNTIH 65

  Fly    66 GFKRLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSA 130
            |||:|.||.|:||.||.|...:|..::...:||.|:||.||.|::.|..||:|.||..||||||.
  Rat    66 GFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGMLLAKLKETSE 130

  Fly   131 AAMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDL--FEDKP 193
            .|::..|.||||:.|.|||:|||::::.|||:||||.|||||||||.|||||.||.||  .::||
  Rat   131 NALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGIYKQDLPSLDEKP 195

  Fly   194 RNVIFVDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKTNA 257
            |||:|:|.|||:.|.|.|||.|||||:||:|:| .:|||:.|.||.|||..||:.:||||.|.|:
  Rat   196 RNVVFIDMGHSAYQVSVCAFNKGKLKVLATTFDPYLGGRNFDEALVDYFCDEFKAKYKINVKENS 260

  Fly   258 RANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLL 322
            ||.|||..|.|||||.||||::.||||||||::|:||||.|.|:|.|:|||.:|.|||...|.::
  Rat   261 RALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNRAQFEQLCASLLARVEPPLKAVM 325

  Fly   323 AESKLQLDDIHSVEIVGGSSRIPSVKQLIEQVFNKPASTTLNQDEAVSRGAALQCAIMSPAVRVR 387
            .::.||.:||:|:|||||::|||:||:.:.:.|.|..|||||.||||:||.||||||:|||.:||
  Rat   326 DQANLQREDINSIEIVGGATRIPAVKEQVTRFFLKDISTTLNADEAVARGCALQCAILSPAFKVR 390

  Fly   388 EFGVTDIQNYAVKVLWDSEGSAAPGEIEIFPQYHASPFSRLLTINRKGPFNVSIVYG--QQVPYP 450
            ||.:||:..|:|.:.|.:......||.|:|.:.|.:|||:::|.::|.||.:...|.  .:||||
  Rat   391 EFSITDLVPYSVTLSWKTSFEEGTGECEVFSKNHPAPFSKVITFHKKEPFELEAFYTNLHEVPYP 455

  Fly   451 DQTIGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAE----EAAAAAEQAASE 511
            |..||.:.:::|.|...|:...||:|||||.:||..::||:::||:..|    :|....|.:.:|
  Rat   456 DPRIGNFTIQNVFPQSDGDSSKVKVKVRINIHGIFSVASASVIEKQNLEGDHNDAPMETEASKNE 520

  Fly   512 EKPGDQTNNTGEPADGQQEAYCEN----EDDNNTSTASSPGGQGWAQRVKGWFGSGADK------ 566
            .|.........:...|.|:.:.|:    |.|:..:.|.:|               .:||
  Rat   521 GKEDVDKMQVDQEEGGHQKCHAEHTPEEEIDHTGAKAKAP---------------PSDKQDRINQ 570

  Fly   567 --KKKASKATELPLECTTHGFSPVDLSN-YTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKL 628
              ||...|:.:||::.:.:.....||.| |.:.|.|||..|:.|.||.|||||:||:|||.|:||
  Rat   571 TIKKGKIKSIDLPIQSSLYRQLTQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDKL 635

  Fly   629 QGGPFERYVVEAEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPIKLRASDYEQGP 693
             |..:|:::...:..|:.:.|.|.||||||:|||..:.:|..:||.|.:...||:::..::|:.|
  Rat   636 -GTVYEKFITPEDMNKLSAMLEDTENWLYEEGEDQPKQVYVDKLQELKKYGQPIQMKYVEHEERP 699

  Fly   694 AAFDELKNSIAIARLAVAEFRKGVPKYDHLTETEFINISETADKAQSWLDANLPKFTQSPRTADS 758
            .|.::|...|.:....:...|....:||||...|...:.:....:.:||::.:....:...|.|.
  Rat   700 KALNDLGKKIQLVLKVIEAHRNKDERYDHLDPAEMEKVEKYISDSMNWLNSKMNAQNKLSLTQDP 764

  Fly   759 PVQISAVRQEVQTLNSCVSSVINRAKPKPTPAKTATPPKDEANAEQNGGEPAANSGDKMDVDNNG 823
            .|::|.:..:.:.|::..:.::.:.|||    ..|...|.:|::|.||.....|..:.......|
  Rat   765 VVKVSEIVTKSKELDNFCNPIVYKPKPK----VEAPEDKTKASSEHNGPMDGQNGAESSPDPPKG 825

  Fly   824 QSAAGNDPSMEVE 836
            .|...:...|||:
  Rat   826 GSQHTDSGEMEVD 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	222/381 (58%)
Hsc70Cb	NP_001189103.1	HSP70	3..682	CDD:278441	331/700 (47%)
Hspa4l	NP_001099898.2	HSPA4L_NBD	2..384	CDD:212688	222/381 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350508
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D285748at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940