Protein Alignment Hsp110 and Hspa4l

DIOPT Version :10

• Sequence 1: NP_001189103.1
• Gene: Hsp110 / 39557
• FlyBaseID: FBgn0026418
• Length: 836
• Species: Drosophila melanogaster
• Sequence 2: NP_001099898.2
• Gene: Hspa4l / 294993
• RGDID: 1306528
• Length: 838
• Species: Rattus norvegicus
• Alignment Length: 858
• Identity: 368/858 - (42%)
• Similarity: 535/858 - (62%)
• Gaps: 42/858 - (4%)

  Fly     1 MSVIGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVG 65
            |||:|||.|..:||:|.||||||||:||:||.|.||:.::...:.|.||.|||:|.|||::||:.
  Rat     1 MSVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNVRNTIH 65

  Fly    66 GFKRLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSA 130
            |||:|.||.|:||.||.|...:|..::...:||.|:||.||.|::.|..||:|.||..||||||.
  Rat    66 GFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGMLLAKLKETSE 130

  Fly   131 AAMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDL--FEDKP 193
            .|::..|.||||:.|.|||:|||::::.|||:||||.|||||||||.|||||.||.||  .::||
  Rat   131 NALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGIYKQDLPSLDEKP 195

  Fly   194 RNVIFVDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKTNA 257
            |||:|:|.|||:.|.|.|||.|||||:||:|:| .:|||:.|.||.|||..||:.:||||.|.|:
  Rat   196 RNVVFIDMGHSAYQVSVCAFNKGKLKVLATTFDPYLGGRNFDEALVDYFCDEFKAKYKINVKENS 260

  Fly   258 RANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLL 322
            ||.|||..|.|||||.||||::.||||||||::|:||||.|.|:|.|:|||.:|.|||...|.::
  Rat   261 RALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNRAQFEQLCASLLARVEPPLKAVM 325

  Fly   323 AESKLQLDDIHSVEIVGGSSRIPSVKQLIEQVFNKPASTTLNQDEAVSRGAALQCAIMSPAVRVR 387
            .::.||.:||:|:|||||::|||:||:.:.:.|.|..|||||.||||:||.||||||:|||.:||
  Rat   326 DQANLQREDINSIEIVGGATRIPAVKEQVTRFFLKDISTTLNADEAVARGCALQCAILSPAFKVR 390

  Fly   388 EFGVTDIQNYAVKVLWDSEGSAAPGEIEIFPQYHASPFSRLLTINRKGPFNVSIVYG--QQVPYP 450
            ||.:||:..|:|.:.|.:......||.|:|.:.|.:|||:::|.::|.||.:...|.  .:||||
  Rat   391 EFSITDLVPYSVTLSWKTSFEEGTGECEVFSKNHPAPFSKVITFHKKEPFELEAFYTNLHEVPYP 455

  Fly   451 DQTIGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAE----EAAAAAEQAASE 511
            |..||.:.:::|.|...|:...||:|||||.:||..::||:::||:..|    :|....|.:.:|
  Rat   456 DPRIGNFTIQNVFPQSDGDSSKVKVKVRINIHGIFSVASASVIEKQNLEGDHNDAPMETEASKNE 520

  Fly   512 EKPGDQTNNTGEPADGQQEAYCEN----EDDNNTSTASSPGGQGWAQRVKGWFGSGADK------ 566
            .|.........:...|.|:.:.|:    |.|:..:.|.:|               .:||
  Rat   521 GKEDVDKMQVDQEEGGHQKCHAEHTPEEEIDHTGAKAKAP---------------PSDKQDRINQ 570

  Fly   567 --KKKASKATELPLECTTHGFSPVDLSN-YTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKL 628
              ||...|:.:||::.:.:.....||.| |.:.|.|||..|:.|.||.|||||:||:|||.|:||
  Rat   571 TIKKGKIKSIDLPIQSSLYRQLTQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDKL 635

  Fly   629 QGGPFERYVVEAEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPIKLRASDYEQGP 693
             |..:|:::...:..|:.:.|.|.||||||:|||..:.:|..:||.|.:...||:::..::|:.|
  Rat   636 -GTVYEKFITPEDMNKLSAMLEDTENWLYEEGEDQPKQVYVDKLQELKKYGQPIQMKYVEHEERP 699

  Fly   694 AAFDELKNSIAIARLAVAEFRKGVPKYDHLTETEFINISETADKAQSWLDANLPKFTQSPRTADS 758
            .|.::|...|.:....:...|....:||||...|...:.:....:.:||::.:....:...|.|.
  Rat   700 KALNDLGKKIQLVLKVIEAHRNKDERYDHLDPAEMEKVEKYISDSMNWLNSKMNAQNKLSLTQDP 764

  Fly   759 PVQISAVRQEVQTLNSCVSSVINRAKPKPTPAKTATPPKDEANAEQNGGEPAANSGDKMDVDNNG 823
            .|::|.:..:.:.|::..:.::.:.|||    ..|...|.:|::|.||.....|..:.......|
  Rat   765 VVKVSEIVTKSKELDNFCNPIVYKPKPK----VEAPEDKTKASSEHNGPMDGQNGAESSPDPPKG 825

  Fly   824 QSAAGNDPSMEVE 836
            .|...:...|||:
  Rat   826 GSQHTDSGEMEVD 838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp110	NP_001189103.1	ASKHA_NBD_HSP70_HSPA4_like	4..378	CDD:466826	217/376 (58%)
Hspa4l	NP_001099898.2	ASKHA_NBD_HSP70_HSPA4L	2..384	CDD:466844	222/381 (58%)