DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70Cb and Hspa9

DIOPT Version :9

Sequence 1:	NP_001189103.1	Gene:	Hsc70Cb / 39557	FlyBaseID:	FBgn0026418	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_001094128.2	Gene:	Hspa9 / 291671	RGDID:	1311806	Length:	679	Species:	Rattus norvegicus

Alignment Length:	729	Identity:	186/729 - (25%)
Similarity:	319/729 - (43%)	Gaps:	141/729 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SVIGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAF--DGKKRIIGVAAKNQQVTNMKNTV 64
            :|:|||.|..:..||.......:.|.|....|.|||.|||  || :|::|:.||.|.|||..||.
  Rat    54 AVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTPDG-ERLVGMPAKRQAVTNPNNTF 117

  Fly    65 GGFKRLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETS 129
            ...|||:||:::||.||.:..::|.::....:|...::.:    .:.:.|.|:.|.:..|:|||:
  Rat   118 YATKRLIGRRYDDPEVQKDTKNVPFKIVRASNGDAWVEAH----GKLYSPSQIGAFVLMKMKETA 178

  Fly   130 AAAMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDLFEDKPR 194
            ...:.....:.||..|.:|.:::|:|..||.||:||||||::||.||.|||||..|:   |||
  Rat   179 ENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKS---EDK-- 238

  Fly   195 NVIFV-DFGHSSLQASACAFTKGKLKMLASTWDQ-IGGRDIDLALGDYFAKEFQERYKINAKTNA 257
             ||.| |.|..:...|.....||..::.::..|. :||.|.|.||..:..|||:....::...:.
  Rat   239 -VIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDN 302

  Fly   258 RANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDID----VSSSMQRSQMEELCAPVLQRVEQTF 318
            .|..|:....||.|.::| :|.:..:|:.....|..    ::..:.|:|.|.:...:::|.....
  Rat   303 MALQRVREAAEKAKCELS-SSVQTDINLPYLTMDASGPKHLNMKLTRAQFEGIVTDLIKRTIAPC 366

  Fly   319 KRLLAESKLQLDDIHSVEIVGGSSRIPSVKQLIEQVFNKPASTTLNQDEAVSRGAALQCAIMSPA 383
            ::.:.::::...||..|.:|||.:|:|.|:|.::.:|.:..|..:|.||||:.|||:|..:::.
  Rat   367 QKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAG- 430

  Fly   384 VRVREFGVTDIQNYAVKVLWDSEGSAAPGEIEIFPQYHASPFSRLLTINRKGPFNVSIVY----- 443
                  .|||:....|..|  |.|....|.:          |::|:..|...|...|.|:
  Rat   431 ------DVTDVLLLDVTPL--SLGIETLGGV----------FTKLINRNTTIPTKKSQVFSTAAD 477

  Fly   444 GQ------------QVPYPDQTIGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKK 496
            ||            ::...::.:|.:.:..:.|..||..| :::...|:.||||.:|
  Rat   478 GQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQ-IEVTFDIDANGIVHVS-------- 533

  Fly   497 EAEEAAAAAEQAASEEKPGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFG 561
             |::.....||....:..|
  Rat   534 -AKDKGTGREQQIVIQSSG---------------------------------------------- 551

  Fly   562 SGADKKKKASKATELPLECTTHGFSPVDLSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRN 626
                                  |.|..|:.|..:...|....|:::.||::|.|..|..::|...
  Rat   552 ----------------------GLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTET 594

  Fly   627 KLQGGPFERYVVEAEREKIVSQLNDLENWL----YEDGEDCERDIYTSRLQALHQKTDPIKLRAS 687
            |::  .|:..:...|..|:..:::.:...|    .|.||:..:...:.:..:|.......|..||
  Rat   595 KME--EFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMAS 657

  Fly   688 DYE-QGPAAFDELK 700
            :.| .|.::..|.|
  Rat   658 EREGSGSSSTGEQK 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	127/386 (33%)
Hsc70Cb	NP_001189103.1	HSP70	3..682	CDD:278441	179/707 (25%)
Hspa9	NP_001094128.2	Interaction with NFS1. /evidence=ECO:0000250\|UniProtKB:P38646	1..432		127/396 (32%)
		dnaK	52..656	CDD:234715	180/712 (25%)
		HSPA9-like_NBD	52..428	CDD:212683	127/385 (33%)
		Interaction with FXN and ISCU. /evidence=ECO:0000250\|UniProtKB:P38646	432..679		59/332 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..679		6/17 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900