DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70Cb and Hsph1

DIOPT Version :9

Sequence 1:	NP_001189103.1	Gene:	Hsc70Cb / 39557	FlyBaseID:	FBgn0026418	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_001011901.1	Gene:	Hsph1 / 288444	RGDID:	1311609	Length:	858	Species:	Rattus norvegicus

Alignment Length:	859	Identity:	366/859 - (42%)
Similarity:	526/859 - (61%)	Gaps:	40/859 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVIGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVG 65
            |||:|:|.|::|||:|.||:|||||:||::|.|.|||.::|..|.|.|||||||||:|:..|||.
  Rat     1 MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGPKNRTIGVAAKNQQITHANNTVS 65

  Fly    66 GFKRLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSA 130
            .|||..||.||||.:|.|..::...:....:|.:||||.|:.||..|..||:||||.||||||:.
  Rat    66 SFKRFHGRAFNDPFIQKEKENLSYDLVPMKNGGVGIKVMYMDEDHLFSVEQITAMLLTKLKETAE 130

  Fly   131 AAMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDL--FEDKP 193
            ..::..|.||||:.|.|||:|||:::||||||.|||.|||||:.||.||.||.||.||  .::||
  Rat   131 NNLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPNADEKP 195

  Fly   194 RNVIFVDFGHSSLQASACAFTKGKLKMLASTWDQ-IGGRDIDLALGDYFAKEFQERYKINAKTNA 257
            |.|:|||.||||.|.|||||.|||||:|.:.:|. :||::.|..|.::|..||:.:||::||:..
  Rat   196 RVVVFVDMGHSSFQVSACAFNKGKLKVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKI 260

  Fly   258 RANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLL 322
            ||.|||..|.|||||.||:|||.||||||||::|.|||:.|.|||.|||||.:||::|.....|:
  Rat   261 RALLRLHQECEKLKKLMSSNSTDLPLNIECFMNDKDVSAKMNRSQFEELCAELLQKIEVPLHLLM 325

  Fly   323 AESKLQLDDIHSVEIVGGSSRIPSVKQLIEQVFNKPASTTLNQDEAVSRGAALQCAIMSPAVRVR 387
            .::.|:.:::.::|||||::|||:||:.|.:.|.|..|||||.||||:||.||||||:|||.:||
  Rat   326 EQTHLKTEEVSAIEIVGGATRIPAVKERIARFFGKDVSTTLNADEAVARGCALQCAILSPAFKVR 390

  Fly   388 EFGVTDIQNYAVKVLWDSEGSAAPGEIEIFPQYHASPFSRLLTINRKGPFNVSIVYG--QQVPYP 450
            ||.|||...:.:.::|:.:.....|..|:|.:.||:|||::||..|:|||.:...|.  |.||||
  Rat   391 EFSVTDAVPFPISLVWNHDSEETEGVHEVFSRNHAAPFSKVLTFLRRGPFELEAFYSDPQAVPYP 455

  Fly   451 DQTIGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAEE---AAAAAEQAASEE 512
            :..||.:.|::|...:.||...||:|||:|.:||..||:|::|||...||   ::..|:.....:
  Rat   456 EAKIGRFVVQNVSAQKDGEKSKVKVKVRVNTHGIFTISTASMVEKVPTEEEDGSSVEADMECPNQ 520

  Fly   513 KPGDQTNNTGEPADGQQEAYCEN--EDDNNTSTASSPGGQGWAQRVKGWFGSGADKKK-----KA 570
            ||.:.::..........||..:.  :.|...::.|.|..:..::..|......|::||     :|
  Rat   521 KPAESSDVDKNIQQDNSEAGTQPQVQTDGQQTSQSPPSPELTSEENKIPDADKANEKKVDQPPEA 585

  Fly   571 SKA------TELPLECTTHGFSPVDLSN-YTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKL 628
            .|.      .|||:|.........||.| |.:.|.|||..|:.|.||.|||||:||.||:.|:||
  Rat   586 KKPKIKVVNVELPVEANLVWQLGRDLLNMYIETEGKMIMQDKLEKERNDAKNAVEECVYEFRDKL 650

  Fly   629 QGGPFERYVVEAEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPIKLRASDYEQGP 693
             .||:|:::.|.|.||.:..|.:.|:||||:|||..:..|..:|:.|.:...|:|:|..:.|:.|
  Rat   651 -CGPYEKFICEQEHEKFLRLLTETEDWLYEEGEDQAKQAYIDKLEELMKMGTPVKVRFQEAEERP 714

  Fly   694 AAFDELKNSIAIARLAVAEFRKGVPKYDHLTETEFINISETADKAQSWLDANLPKFTQSPRTADS 758
            ...:||...:.......|:||....||:|:.|:|...:.::.::...|::..:....:.....|.
  Rat   715 RVLEELGQRLQHYAKIAADFRGKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKRSLHQDP 779

  Fly   759 PVQISAVRQEVQTLNSCVSSVINRAKPK-PTPAKTATP------PKDE--------ANAEQNGGE 808
            .|:...:..:|:.||:....|:.:.||| .:|....||      .|::        |:|....||
  Rat   780 VVRTHEISAKVKELNNVCEPVVTQPKPKIESPKLERTPNGPNMDKKEDLEGKSNLGADAPHQNGE 844

  Fly   809 --PAANSGDKMDVD 820
              |.......||:|
  Rat   845 CHPNEKGSVSMDLD 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	214/381 (56%)
Hsc70Cb	NP_001189103.1	HSP70	3..682	CDD:278441	327/700 (47%)
Hsph1	NP_001011901.1	HSPH1_NBD	2..384	CDD:212689	214/381 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..585		15/84 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	801..858		14/56 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350509
Domainoid	1	1.000	600	1.000	Domainoid score	I188
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	670	1.000	Inparanoid score	I705
OMA	1	1.010	-	-		QHG54058
OrthoDB	1	1.010	-	-		D285748at33208
OrthoFinder	1	1.000	-	-		FOG0001023
OrthoInspector	1	1.000	-	-		otm44435
orthoMCL	1	0.900	-	-		OOG6_100680
Panther	1	1.100	-	-	O	PTHR45639
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X684
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770