DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70Cb and Hspa4

DIOPT Version :9

Sequence 1:	NP_001189103.1	Gene:	Hsc70Cb / 39557	FlyBaseID:	FBgn0026418	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_705893.1	Gene:	Hspa4 / 266759	RGDID:	628878	Length:	840	Species:	Rattus norvegicus

Alignment Length:	878	Identity:	381/878 - (43%)
Similarity:	534/878 - (60%)	Gaps:	80/878 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVIGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVG 65
            |||:|||.|.:|||||.||:|||||:||:||.|.||:.|:|..|.|.:|.|||:|.::|.||||.
  Rat     1 MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACVSFGPKNRSVGAAAKSQVISNAKNTVQ 65

  Fly    66 GFKRLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSA 130
            ||||..||.|:||.|:.|.:::...:.....|..||||.|:.|:::|..||:||||.:|||||:.
  Rat    66 GFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAMLLSKLKETAE 130

  Fly   131 AAMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDL--FEDKP 193
            :.::..|.|||::.|.|:|:|||::::||.||||||.|||||||||.|||||.||.||  .|:||
  Rat   131 SVLKKPVVDCVVSVPSFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKP 195

  Fly   194 RNVIFVDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKTNA 257
            |||:|||.|||:.|.|.|||.:||||:||:.:| .:|||..|..|.::|.:||.::||::.|:..
  Rat   196 RNVVFVDMGHSAYQVSVCAFNRGKLKVLATAFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSKV 260

  Fly   258 RANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLL 322
            ||.|||..|.|||||.||||::.|||:||||::|||||.:|.|.:..|:|..:|.|||...:.:|
  Rat   261 RALLRLSQECEKLKKLMSANASDLPLSIECFMNDIDVSGTMNRGKFLEMCDDLLARVEPPLRSIL 325

  Fly   323 AESKLQLDDIHSVEIVGGSSRIPSVKQLIEQVFNKPASTTLNQDEAVSRGAALQCAIMSPAVRVR 387
            .:|||:.:||::||||||::|||:||:.|.:.|.|..|||||.||||:||.||||||:|||.:||
  Rat   326 DQSKLKKEDIYAVEIVGGATRIPAVKEKISKFFGKELSTTLNADEAVTRGCALQCAILSPAFKVR 390

  Fly   388 EFGVTDIQNYAVKVLWDSEGSAAPGEIEIFPQYHASPFSRLLTINRKGPFNVSIVYG--QQVPYP 450
            ||.:||:..|.:.:.|:|.......:.|:||:.||:|||::||..||.||.:...|.  |.:|||
  Rat   391 EFSITDVVPYPISLRWNSPAEEGSSDCEVFPKNHAAPFSKVLTFYRKEPFTLEAYYSSPQDLPYP 455

  Fly   451 DQTIGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVE---KKEAEEAAAAAEQAASEE 512
            |..|..:.|:.|.|...|....||:|||:|.:||..:|||.|||   .:|:||.....:.|..||
  Rat   456 DPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSAALVEVHKSEESEEPMETDQNAKEEE 520

  Fly   513 K-------PGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGSGADKK--- 567
            |       |..:......||:.:.|:     ::..||.|.|                 .|||
  Rat   521 KMQVDQEEPHTEEQQPQTPAENKAES-----EEMETSQAGS-----------------KDKKMDQ 563

  Fly   568 ----KKASKAT---ELPLECTTHGFSPVD---LSNYTQQESKMIGNDQKETERIDAKNALEEFVY 622
                |||...|   :||:|  :.....:|   |..||:.|.|||..|:.|.||.|||||:||:||
  Rat   564 PPQAKKAKVKTSTVDLPIE--SQLLWQLDREMLGLYTENEGKMIMQDKLEKERNDAKNAVEEYVY 626

  Fly   623 DMRNKLQGGPFERYVVEAEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPIKLRAS 687
            :||:|| .|.:|::|.|.:|.....:|.|.||||||||||..:.:|..:|..|.....|||.|..
  Rat   627 EMRDKL-SGEYEKFVSEDDRNNFTLKLEDTENWLYEDGEDQPKQVYVDKLAELRTLGQPIKTRFQ 690

  Fly   688 DYEQGPAAFDELKNSIAIARLAVAEFRKGVPKYDHLTETEFINISETADKAQSWLDANLPKFTQS 752
            :.|:.|..|:||...|......::.|:....:|:||...:...:.::.::|..|:::.|....:.
  Rat   691 ESEERPKLFEELGKQIQQYMKVISSFKNKEDQYEHLDAADMTKVEKSTNEAMEWMNSKLNLQNKQ 755

  Fly   753 PRTADSPVQISAVRQEVQTLNSCVSSVINRAKPKPTPAKTATPPKDE-ANAEQNGGEPAANSGDK 816
            ..|||..|:...:..:::.|.:..|.:|::.|||      ..|||:| .:|||||  |....|
  Rat   756 SLTADPVVKTKEIEAKIKELTNICSPIISKPKPK------VEPPKEEPKHAEQNG--PVDGQG-- 810

  Fly   817 MDVDNNGQSAA--GND-----------PSMEVE 836
               ||.|..||  |.|           |.|:::
  Rat   811 ---DNPGTQAAEHGADTAVPSDGDKKLPEMDID 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	212/381 (56%)
Hsc70Cb	NP_001189103.1	HSP70	3..682	CDD:278441	332/706 (47%)
Hspa4	NP_705893.1	HSPA4_NBD	2..384	CDD:212687	212/381 (56%)
		PTZ00121	<499..743	CDD:173412	86/268 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..575		21/96 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	781..840		24/71 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350510
Domainoid	1	1.000	600	1.000	Domainoid score	I188
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1624
Inparanoid	1	1.050	670	1.000	Inparanoid score	I705
OMA	1	1.010	-	-		QHG54058
OrthoDB	1	1.010	-	-		D285748at33208
OrthoFinder	1	1.000	-	-		FOG0001023
OrthoInspector	1	1.000	-	-		otm44435
orthoMCL	1	0.900	-	-		OOG6_100680
Panther	1	1.100	-	-	LDO	PTHR45639
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X684
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770