Protein Alignment Hsc70Cb and HSPA12A

DIOPT Version :9

• Sequence 1: NP_001189103.1
• Gene: Hsc70Cb / 39557
• FlyBaseID: FBgn0026418
• Length: 836
• Species: Drosophila melanogaster
• Sequence 2: NP_001317093.1
• Gene: HSPA12A / 259217
• HGNCID: 19022
• Length: 692
• Species: Homo sapiens
• Alignment Length: 585
• Identity: 106/585 - (18%)
• Similarity: 189/585 - (32%)
• Gaps: 196/585 - (33%)

  Fly     3 VIGIDFGN-------------ESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRI--IGVAA 52
            |:.:|||.             |..:|.....||...::|    :.||:.:....:::.  .|.||
Human    75 VVAVDFGTTSSGYAYSFTKEPECIHVMRRWEGGDPGVSN----QKTPTTILLTPERKFHSFGYAA 135

  Fly    53 KNQQVTNMKNTVGGFKRLLGRKFNDPHVQHE---LTSIPARVEARGD--------GSIGIKVNYL 106
            ::            |...|     ||:...:   |.....::...||        .:.|.||..|
Human   136 RD------------FYHDL-----DPNEAKQWLYLEKFKMKLHTTGDLTMDTDLTAANGKKVKAL 183

  Fly   107 GEDQHFGPEQLTAMLFTKLKETSAAAMQTQVND--------CVIACPVFFTNAERKALLDAAQIA 163
                     ::.|......||.:...:..|...        .||..|..:....::.:..||..|
Human   184 ---------EIFAYALQYFKEQALKELSDQAGSEFENSDVRWVITVPAIWKQPAKQFMRQAAYQA 239

  Fly   164 GL-------NVLRLMNETTATALAYGFYKNDLFEDKPRNVIFVDFGHSSLQASACAFTKGK---- 217
            ||       .::..:....|:........:.:.|...:..:   .|:|........||:.|
Human   240 GLASPENSEQLIIALEPEAASIYCRKLRLHQMIELSSKAAV---NGYSGSDTVGAGFTQAKEHIR 301

  Fly   218 ----------LKMLASTWDQI-----------GGRDIDL------------------------AL 237
                      ..::...|.::           ||..:||                        :|
Human   302 RNRQSRTFLVENVIGEIWSELEEGDKYVVVDSGGGTVDLTVHQIRLPEGHLKELYKATGGPYGSL 366

  Fly   238 G-DY---------FAKEFQERYKINAKTNARANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDI 292
            | ||         |.::|.|::||.   ...|.:.|:...|..|:..:.:.|. ||||......|
Human   367 GVDYEFEKLLYKIFGEDFIEQFKIK---RPAAWVDLMIAFESRKRAAAPDRTN-PLNITLPFSFI 427

  Fly   293 D---------VSSSMQRSQ------------------MEELCAPVLQRVEQTFKRLLAESKLQLD 330
            |         |..::::|.                  |..|..|.:..:.:..:.|.  .|.::.
Human   428 DYYKKFRGHSVEHALRKSNVDFVKWSSQGMLRMSPDAMNALFKPTIDSIIEHLRDLF--QKPEVS 490

  Fly   331 DIHSVEIVGGSSRIPSVKQLIEQVFNKPASTTLNQDEAVS--RGAALQCAIMSPAV-RVRE---- 388
            .:..:.:|||.:..|.::|.::..|.......:.||..::  :||.|  ..:.||| :||.
Human   491 TVKFLFLVGGFAEAPLLQQAVQAAFGDQCRIIIPQDVGLTILKGAVL--FGLDPAVIKVRRSPLT 553

  Fly   389 FGVTDIQNYA------VKVL------W---------DSEGSAAPGEIEIFPQYHASPFSRLLTIN 432
            :||..:..|.      .|:|      |         .::.|.|.||:.......|.|...::.||
Human   554 YGVGVLNRYVEGKHPPEKLLVKDGTRWCTDVFDKFISADQSVALGELVKRSYTPAKPSQLVIVIN 618

  Fly   433  432
            Human   619  618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	87/506 (17%)
		HSP70	3..682	CDD:278441	106/585 (18%)
HSPA12A	NP_001317093.1	HSPA12A_like_NBD	74..540	CDD:212685	87/505 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900