DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70Cb and Hspa5

DIOPT Version :9

Sequence 1:	NP_001189103.1	Gene:	Hsc70Cb / 39557	FlyBaseID:	FBgn0026418	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_037215.1	Gene:	Hspa5 / 25617	RGDID:	2843	Length:	654	Species:	Rattus norvegicus

Alignment Length:	712	Identity:	198/712 - (27%)
Similarity:	338/712 - (47%)	Gaps:	120/712 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SVIGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGK-KRIIGVAAKNQQVTNMKNTVG 65
            :|:|||.|.....|...::|.:|.:|||...|.|||:|||..: :|:||.|||||..:|.:|||.
  Rat    29 TVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVF 93

  Fly    66 GFKRLLGRKFNDPHVQHELTSIPAR-VEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETS 129
            ..|||:||.:|||.||.::..:|.: ||.:....|.:.:.. |:.:.|.||:::||:.||:|||:
  Rat    94 DAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGG-GQTKTFAPEEISAMVLTKMKETA 157

  Fly   130 AAAMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDLFEDKPR 194
            .|.:..:|...|:..|.:|.:|:|:|..||..||||||:|::||.||.|:|||..|    .:..:
  Rat   158 EAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDK----REGEK 218

  Fly   195 NVIFVDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKTNAR 258
            |::..|.|..:...|......|..:::|:..| .:||.|.|..:.::|.|.::::...:.:.:.|
  Rat   219 NILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNR 283

  Fly   259 ANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLLA 323
            |..:|..|:||.|:.:|:.. :..:.||.|.:..|.|.::.|::.|||...:.:...:..:::|.
  Rat   284 AVQKLRREVEKAKRALSSQH-QARIEIESFFEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLE 347

  Fly   324 ESKLQLDDIHSVEIVGGSSRIPSVKQLIEQVFN-KPASTTLNQDEAVSRGAALQCAIMSPAVRVR 387
            :|.|:..||..:.:||||:|||.::||:::.|| |..|..:|.||||:.|||:|..::|......
  Rat   348 DSDLKKSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTG 412

  Fly   388 EFGVTDIQNYAVKVLWDSEGSAAPGEI---EIFPQYHASPFSRLLTINRKGPFNVSIVYGQQVPY 449
            :..:.|:....:.:  ::.|......|   .:.|...:..||   |.:...|.....||..:.|.
  Rat   413 DLVLLDVCPLTLGI--ETVGGVMTKLIPRNTVVPTKKSQIFS---TASDNQPTVTIKVYEGERPL 472

  Fly   450 --PDQTIGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAEEAAAAAEQAASEE 512
              .:..:|.:.:..:.|..||..| :::...|:.|||:.::                     :|:
  Rat   473 TKDNHLLGTFDLTGIPPAPRGVPQ-IEVTFEIDVNGILRVT---------------------AED 515

  Fly   513 KPGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGSGADKKKKASKATELP 577
            |                                                 |...|.|.:...:
  Rat   516 K-------------------------------------------------GTGNKNKITITND-- 529

  Fly   578 LECTTHGFSPVDLSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRN------KLQG--GPFE 634
                .:..:|.::........|....|:|..||||.:|.||.:.|.::|      ||.|  .|.:
  Rat   530 ----QNRLTPEEIERMVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSPED 590

  Fly   635 RYVVE-AEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPI--KLRASDYEQGP 693
            :..:| |..|||        .|| |..:|.:.:.:.::.:.|.:...||  ||..|.   ||
  Rat   591 KETMEKAVEEKI--------EWL-ESHQDADIEDFKAKKKELEEIVQPIISKLYGSG---GP 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	138/382 (36%)
Hsc70Cb	NP_001189103.1	HSP70	3..682	CDD:278441	191/696 (27%)
Hspa5	NP_037215.1	Required for interaction with KIAA1324. /evidence=ECO:0000250\|UniProtKB:P11021	1..80		21/50 (42%)
		HSPA5-like_NBD	28..403	CDD:212681	138/379 (36%)
		HSP70	30..635	CDD:278441	194/701 (28%)
		Nucleotide-binding (NBD). /evidence=ECO:0000250\|UniProtKB:P11021	125..280		51/159 (32%)
		Interdomain linker. /evidence=ECO:0000250\|UniProtKB:G3I8R9	409..419		0/9 (0%)
		Substrate-binding (SBD). /evidence=ECO:0000250\|UniProtKB:P11021	420..500		15/85 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	631..654		5/13 (38%)
		Prevents secretion from ER	651..654
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810