DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsp110 and Hspa5

DIOPT Version :10

Sequence 1:NP_001189103.1 Gene:Hsp110 / 39557 FlyBaseID:FBgn0026418 Length:836 Species:Drosophila melanogaster
Sequence 2:NP_037215.1 Gene:Hspa5 / 25617 RGDID:2843 Length:654 Species:Rattus norvegicus


Alignment Length:712 Identity:198/712 - (27%)
Similarity:338/712 - (47%) Gaps:120/712 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SVIGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGK-KRIIGVAAKNQQVTNMKNTVG 65
            :|:|||.|.....|...::|.:|.:|||...|.|||:|||..: :|:||.|||||..:|.:|||.
  Rat    29 TVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVF 93

  Fly    66 GFKRLLGRKFNDPHVQHELTSIPAR-VEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETS 129
            ..|||:||.:|||.||.::..:|.: ||.:....|.:.:.. |:.:.|.||:::||:.||:|||:
  Rat    94 DAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGG-GQTKTFAPEEISAMVLTKMKETA 157

  Fly   130 AAAMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDLFEDKPR 194
            .|.:..:|...|:..|.:|.:|:|:|..||..||||||:|::||.||.|:|||..|    .:..:
  Rat   158 EAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDK----REGEK 218

  Fly   195 NVIFVDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKTNAR 258
            |::..|.|..:...|......|..:::|:..| .:||.|.|..:.::|.|.::::...:.:.:.|
  Rat   219 NILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNR 283

  Fly   259 ANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLLA 323
            |..:|..|:||.|:.:|:.. :..:.||.|.:..|.|.::.|::.|||...:.:...:..:::|.
  Rat   284 AVQKLRREVEKAKRALSSQH-QARIEIESFFEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLE 347

  Fly   324 ESKLQLDDIHSVEIVGGSSRIPSVKQLIEQVFN-KPASTTLNQDEAVSRGAALQCAIMSPAVRVR 387
            :|.|:..||..:.:||||:|||.::||:::.|| |..|..:|.||||:.|||:|..::|......
  Rat   348 DSDLKKSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTG 412

  Fly   388 EFGVTDIQNYAVKVLWDSEGSAAPGEI---EIFPQYHASPFSRLLTINRKGPFNVSIVYGQQVPY 449
            :..:.|:....:.:  ::.|......|   .:.|...:..||   |.:...|.....||..:.|.
  Rat   413 DLVLLDVCPLTLGI--ETVGGVMTKLIPRNTVVPTKKSQIFS---TASDNQPTVTIKVYEGERPL 472

  Fly   450 --PDQTIGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAEEAAAAAEQAASEE 512
              .:..:|.:.:..:.|..||..| :::...|:.|||:.::                     :|:
  Rat   473 TKDNHLLGTFDLTGIPPAPRGVPQ-IEVTFEIDVNGILRVT---------------------AED 515

  Fly   513 KPGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGSGADKKKKASKATELP 577
            |                                                 |...|.|.:...:  
  Rat   516 K-------------------------------------------------GTGNKNKITITND-- 529

  Fly   578 LECTTHGFSPVDLSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRN------KLQG--GPFE 634
                .:..:|.::........|....|:|..||||.:|.||.:.|.::|      ||.|  .|.:
  Rat   530 ----QNRLTPEEIERMVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSPED 590

  Fly   635 RYVVE-AEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPI--KLRASDYEQGP 693
            :..:| |..|||        .|| |..:|.:.:.:.::.:.|.:...||  ||..|.   ||
  Rat   591 KETMEKAVEEKI--------EWL-ESHQDADIEDFKAKKKELEEIVQPIISKLYGSG---GP 640

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsp110NP_001189103.1 ASKHA_NBD_HSP70_HSPA4_like 4..378 CDD:466826 137/377 (36%)
Hspa5NP_037215.1 Required for interaction with ELAPOR1. /evidence=ECO:0000250|UniProtKB:P11021 1..80 21/50 (42%)
HSP70 30..635 CDD:394970 194/701 (28%)
Nucleotide-binding (NBD). /evidence=ECO:0000250|UniProtKB:P11021 125..280 51/159 (32%)
Interdomain linker. /evidence=ECO:0000250|UniProtKB:G3I8R9 409..419 0/9 (0%)
Substrate-binding (SBD). /evidence=ECO:0000250|UniProtKB:P11021 420..500 15/85 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 631..654 5/13 (38%)
Prevents secretion from ER 651..654
Blue background indicates that the domain is not in the aligned region.

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