DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70Cb and Hspa1l

DIOPT Version :9

Sequence 1:	NP_001189103.1	Gene:	Hsc70Cb / 39557	FlyBaseID:	FBgn0026418	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_997711.1	Gene:	Hspa1l / 24963	RGDID:	1595925	Length:	641	Species:	Rattus norvegicus

Alignment Length:	707	Identity:	206/707 - (29%)
Similarity:	350/707 - (49%)	Gaps:	117/707 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVGGFK 68
            ||||.|.....|...:.|.:|.:|||...|.|||:|||...:|:||.|||||...|.:|||...|
  Rat     9 IGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPQNTVFDAK 73

  Fly    69 RLLGRKFNDPHVQHELTSIPARV--EARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSAA 131
            ||:|||||||.||.::...|.:|  ||   |...:.|:|.||.:.|.||::::|:.||:|||:.|
  Rat    74 RLIGRKFNDPVVQSDMKLWPFQVINEA---GKPKVLVSYKGEKKAFYPEEISSMVLTKMKETAEA 135

  Fly   132 AMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDLFEDKPRNV 196
            .:...|.:.||..|.:|.:::|:|..||..||||||||::||.||.|:|||..|....|   |:|
  Rat   136 FLGHSVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGSHGE---RHV 197

  Fly   197 IFVDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKTNARAN 260
            :..|.|..:...|......|..::.|:..| .:||.|.|..|..:|.:||:.::|.:...|.||.
  Rat   198 LIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAV 262

  Fly   261 LRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLLAES 325
            .||.|..|:.|:.:| :||:..|.|:...:.||..:|:.|::.|||||.:.:...:..::.|.::
  Rat   263 RRLRTACERAKRTLS-SSTQANLEIDSLYEGIDFYTSITRARFEELCADLFRGTLEPVEKSLRDA 326

  Fly   326 KLQLDDIHSVEIVGGSSRIPSVKQLIEQVFN-KPASTTLNQDEAVSRGAALQCAIM--SPAVRVR 387
            |:....||.:.:||||:|||.|::|::..|| :..:.::|.||||:.|||:|.||:  ..:.:|:
  Rat   327 KMDKAKIHDIVLVGGSTRIPKVQKLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSEKVQ 391

  Fly   388 EFGVTDIQNYA---------VKVLWDSEGSAAPGEIEIFPQYHASPFSRLLTINRKGPFNVSIVY 443
            :..:.|:...:         :.||.....:....:.:||..|         :.|:.|.. :.:..
  Rat   392 DLLLLDVAPLSLGLETAGGVMTVLIKRNSTIPTKQTQIFTTY---------SDNQPGVL-IQVYE 446

  Fly   444 GQQVPYPDQT-IGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAEEAAAAAEQ 507
            |::....|.. :|.:.:..:.|..||..| :::...|:.|||:   :.|.::|
  Rat   447 GERAMTRDNNLLGRFDLTGIPPAPRGVPQ-IEVTFDIDANGIL---NVTAMDK------------ 495

  Fly   508 AASEEKPGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGSGADKKKKASK 572
                        :||:.               |..|.::..|:
  Rat   496 ------------STGKA---------------NKITITNDKGR---------------------- 511

  Fly   573 ATELPLECTTHGFSPVDLSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQGGPFERYV 637
                        .|..::....|:..:....|:.:.|:|.||||||.:.::|::.:.....:..:
  Rat   512 ------------LSKEEIERMVQEAERYKAEDEGQREKIAAKNALESYAFNMKSAVGDEGLKDKI 564

  Fly   638 VEAEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPI--KLRASDYEQG 692
            .|::::||:.:.:::.:|| |..:..|::.:..:.:.|....:||  ||    |:.|
  Rat   565 SESDKKKILDKCSEVLSWL-EANQLAEKEEFDHKRKELENMCNPIITKL----YQSG 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	153/382 (40%)
Hsc70Cb	NP_001189103.1	HSP70	3..682	CDD:278441	200/693 (29%)
Hspa1l	NP_997711.1	PTZ00009	3..641	CDD:240227	206/707 (29%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	3..388		153/385 (40%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	396..511		25/167 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350507
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740