DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsc70Cb and Hspa1a

DIOPT Version :9

Sequence 1:NP_001189103.1 Gene:Hsc70Cb / 39557 FlyBaseID:FBgn0026418 Length:836 Species:Drosophila melanogaster
Sequence 2:NP_114177.2 Gene:Hspa1a / 24472 RGDID:1593284 Length:641 Species:Rattus norvegicus


Alignment Length:702 Identity:202/702 - (28%)
Similarity:346/702 - (49%) Gaps:98/702 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SVIGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVGG 66
            :.||||.|.....|...:.|.:|.:|||...|.|||:|||...:|:||.|||||...|.:|||..
  Rat     5 TAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFD 69

  Fly    67 FKRLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSAA 131
            .|||:||||.||.||.::...|.:|...|| ...::|||.||::.|.||::::|:.||:||.:.|
  Rat    70 AKRLIGRKFGDPVVQSDMKHWPFQVVNDGD-KPKVQVNYKGENRSFYPEEISSMVLTKMKEIAEA 133

  Fly   132 AMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDLFEDKPRNV 196
            .:...|.:.||..|.:|.:::|:|..||..||||||||::||.||.|:|||..:....|   |||
  Rat   134 YLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGE---RNV 195

  Fly   197 IFVDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKTNARAN 260
            :..|.|..:...|......|..::.|:..| .:||.|.|..|..:|.:||:.::|.:...|.||.
  Rat   196 LIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAV 260

  Fly   261 LRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLLAES 325
            .||.|..|:.|:.:| :||:..|.|:...:.||..:|:.|::.||||:.:.:...:..::.|.::
  Rat   261 RRLRTACERAKRTLS-SSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRGTLEPVEKALRDA 324

  Fly   326 KLQLDDIHSVEIVGGSSRIPSVKQLIEQVFN-KPASTTLNQDEAVSRGAALQCAIM--SPAVRVR 387
            ||....||.:.:||||:|||.|::|::..|| :..:.::|.||||:.|||:|.||:  ..:..|:
  Rat   325 KLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQ 389

  Fly   388 EFGVTDIQNYAVKVLWDSEGSAAPGEIE---IFPQYHASPFSRLLTINRKGPFNVSIVYGQQVPY 449
            :..:.|:...::.:  ::.|......|:   ..|......|: ..:.|:.|.. :.:..|::...
  Rat   390 DLLLLDVAPLSLGL--ETAGGVMTALIKRNSTIPTKQTQTFT-TYSDNQPGVL-IQVYEGERAMT 450

  Fly   450 PDQT-IGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAEEAAAAAEQAASEEK 513
            .|.. :|.:::..:.|..||..| :::...|:.|||:                            
  Rat   451 RDNNLLGRFELSGIPPAPRGVPQ-IEVTFDIDANGIL---------------------------- 486

  Fly   514 PGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGSGADKKKKASKATELPL 578
                                     |.|:|..|.|                       ||.::.:
  Rat   487 -------------------------NVTATDKSTG-----------------------KANKITI 503

  Fly   579 ECTTHGFSPVDLSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQGGPFERYVVEAERE 643
            .......|..::....|:..:....|:.:.||:.||||||.:.::|::.::....:..:.||:::
  Rat   504 TNDKGRLSKEEIERMVQEAERYKAEDEVQRERVAAKNALESYAFNMKSAVEDEGLKGKISEADKK 568

  Fly   644 KIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPIKLRASDYEQGPAA 695
            |::.:..::.:|| :.....|::.:..:.:.|.:..:||   .|...||..|
  Rat   569 KVLDKCQEVISWL-DSNTLAEKEEFVHKREELERVCNPI---ISGLYQGAGA 616

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsc70CbNP_001189103.1 HSPA4_like_NDB 2..381 CDD:212670 151/382 (40%)
HSP70 3..682 CDD:278441 196/686 (29%)
Hspa1aNP_114177.2 PTZ00009 1..641 CDD:240227 202/702 (29%)
Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142 2..386 151/385 (39%)
HSPA1-2_6-8-like_NBD 6..381 CDD:212675 151/379 (40%)
Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142 394..509 25/195 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 618..641
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166350500
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.840

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