DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsp110 and Hspa8

DIOPT Version :10

Sequence 1:NP_001189103.1 Gene:Hsp110 / 39557 FlyBaseID:FBgn0026418 Length:836 Species:Drosophila melanogaster
Sequence 2:NP_077327.1 Gene:Hspa8 / 24468 RGDID:621725 Length:646 Species:Rattus norvegicus


Alignment Length:690 Identity:189/690 - (27%)
Similarity:338/690 - (48%) Gaps:101/690 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 IGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVGGFK 68
            :|||.|.....|...:.|.:|.:|||...|.|||:|||...:|:||.|||||...|..|||...|
  Rat     7 VGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFDAK 71

  Fly    69 RLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSAAAM 133
            ||:||:|:|..||.::...|..| ....|...::|.|.||.:.|.||::::|:.||:||.:.|.:
  Rat    72 RLIGRRFDDAVVQSDMKHWPFMV-VNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAYL 135

  Fly   134 QTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDLFEDKPRNVIF 198
            ...|.:.|:..|.:|.:::|:|..||..||||||||::||.||.|:|||..|....|   |||:.
  Rat   136 GKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAE---RNVLI 197

  Fly   199 VDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKTNARANLR 262
            .|.|..:...|......|..::.::..| .:||.|.|..:.::|..||:.::|.:...|.||..|
  Rat   198 FDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRR 262

  Fly   263 LLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLLAESKL 327
            |.|..|:.|:.:| :||:..:.|:...:.||..:|:.|::.|||.|.:.:......::.|.::||
  Rat   263 LRTACERAKRTLS-SSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKL 326

  Fly   328 QLDDIHSVEIVGGSSRIPSVKQLIEQVFN-KPASTTLNQDEAVSRGAALQCAIMS--PAVRVREF 389
            ....||.:.:||||:|||.:::|::..|| |..:.::|.||||:.|||:|.||:|  .:..|::.
  Rat   327 DKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDL 391

  Fly   390 GVTDIQNYAVKVLWDSEGSAAPGEIEIFPQYHAS-PFSRLLTI-----NRKGPFNVSIVYGQQVP 448
            .:.|:...::.:      ..|.|.:.:..:.:.: |..:..|.     |:.|.. :.:..|::..
  Rat   392 LLLDVTPLSLGI------ETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVL-IQVYEGERAM 449

  Fly   449 YPDQT-IGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAEEAAAAAEQAASEE 512
            ..|.. :|.:::..:.|..||..| :::...|:.|||:.:|               |.:::..:|
  Rat   450 TKDNNLLGKFELTGIPPAPRGVPQ-IEVTFDIDANGILNVS---------------AVDKSTGKE 498

  Fly   513 KPGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGSGADKKKKASKATELP 577
            .....||:.|.                                                      
  Rat   499 NKITITNDKGR------------------------------------------------------ 509

  Fly   578 LECTTHGFSPVDLSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQGGPFERYVVEAER 642
                   .|..|:....|:..|....|:|:.:::.:||:||.:.::|:..::....:..:.:.::
  Rat   510 -------LSKEDIERMVQEAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDK 567

  Fly   643 EKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPI 682
            :||:.:.|::.:|| :..:..|::.:..:.:.|.:..:||
  Rat   568 QKILDKCNEIISWL-DKNQTAEKEEFEHQQKELEKVCNPI 606

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsp110NP_001189103.1 ASKHA_NBD_HSP70_HSPA4_like 4..378 CDD:466826 141/375 (38%)
Hspa8NP_077327.1 PTZ00009 1..613 CDD:240227 189/690 (27%)
Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142 2..386 144/383 (38%)
Interaction with BAG1. /evidence=ECO:0000250 186..377 62/194 (32%)
Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142 394..509 23/137 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 614..646
Blue background indicates that the domain is not in the aligned region.

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