DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70Cb and hsp-110

DIOPT Version :9

Sequence 1:	NP_001189103.1	Gene:	Hsc70Cb / 39557	FlyBaseID:	FBgn0026418	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_498868.1	Gene:	hsp-110 / 176195	WormBaseID:	WBGene00016250	Length:	776	Species:	Caenorhabditis elegans

Alignment Length:	831	Identity:	337/831 - (40%)
Similarity:	478/831 - (57%)	Gaps:	66/831 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVIGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVG 65
            |||:|.|.||.:||:..||.||||.:.|||||.|||:.|:|..|.|.:||||:....||:||||.
Worm     1 MSVLGFDIGNLNCYIGVARQGGIEVITNDYSLHATPACVSFGPKDRSMGVAARQAVTTNIKNTVI 65

  Fly    66 GFKRLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSA 130
            .||.|:||||:||..|..:..||.:|....:..||::|:||||...|.|||:.|.|.|||:....
Worm    66 NFKHLIGRKFSDPVAQRFIPFIPCKVVKLPNDDIGVQVSYLGEPHTFTPEQVLAALLTKLRTIVE 130

  Fly   131 AAMQ--TQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDLFED-- 191
            :.:.  .:|:|||:|.|.:||:.:|:|:|.|.|.||||.||::|||||.|||||.||.||.|:
Worm   131 SQLSDVKKVSDCVLAVPSYFTDVQRRAVLSAIQYAGLNSLRIVNETTAIALAYGIYKQDLPEEDA 195

  Fly   192 KPRNVIFVDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKT 255
            |.|||:|:|.||||.|||..||.:|||:|:.:::| :.||...|..:.::|.|||:.:|.|:|.|
Worm   196 KSRNVVFLDIGHSSTQASLVAFNRGKLQMVNTSYDLESGGIWFDALIREHFRKEFKTKYGIDAAT 260

  Fly   256 NARANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKR 320
            :.|..||||.|.|::|||||||.|.:|||||||::|.||:..|||.:.|:|.||:..|::|....
Worm   261 SPRPWLRLLDECERVKKQMSANQTPIPLNIECFMEDKDVTGKMQRQEFEDLAAPIFNRIKQVLIN 325

  Fly   321 LLAES-KLQLDDIHSVEIVGGSSRIPSVKQLIEQVFNKPASTTLNQDEAVSRGAALQCAIMSPAV 384
            |.|:. .::.::|..:||||||||||.::::::.:|.|...||:||||||:||||:||||:||..
Worm   326 LFADGVSIKPEEIDEIEIVGGSSRIPMIREIVKDLFGKEPKTTMNQDEAVARGAAMQCAILSPTF 390

  Fly   385 RVREFGVTDIQNYAVKVLWDSEGSAAPGEIEIFPQYHASPFSRLLTINRKGPFNVSIVYGQQ--V 447
            |||||.:.|.|.|.:::.|:|.|... ||.::|......|||:|:::.|.|||||...|.|.  |
Worm   391 RVREFAIKDTQPYRIRLSWNSTGENG-GENDVFSPRDEVPFSKLVSLLRSGPFNVEAHYAQPNVV 454

  Fly   448 PYPDQTIGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAEEAAAAAEQAASEE 512
            |:....||.|||...:|...|..|.||:|||:|.:||..|:|||:.|.:..||..|.|.:...:.
Worm   455 PHNQVHIGSWKVNGARPGADGGNQKVKVKVRVNPDGIFTIASATMYEPRIVEEVPAEAMEVDGDA 519

  Fly   513 KPGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGSGADKKKKASKATELP 577
            |       |..||:..:..                                  ||.|.     :|
Worm   520 K-------TEAPAEPLEPV----------------------------------KKTKL-----VP 538

  Fly   578 LECTTHGFSPV--DLSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQGGPFERYVVEA 640
            ::.......||  |:..:...|.:|..:|.:|..:.||||:|||:||:||:|: ...:..::..|
Worm   539 VDLEVIESIPVSYDVQKFHNLELQMQESDAREKAKADAKNSLEEYVYEMRDKV-SDQYAEFITPA 602

  Fly   641 EREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPIKLRASDYEQGPAAFDELKNSIAI 705
            ..::..|.|...|:|||::|||.|||:|..||..|.....|:..|..:.|....|||....||..
Worm   603 AADEFRSVLTSTEDWLYDEGEDAERDVYEKRLSELKAVGTPVVERYRESETRKPAFDSFDQSIMR 667

  Fly   706 ARLAVAEFRKGVPKYDHLTETEFINISETADKAQSWLDANLPKFTQSPRTADSPVQIS-AVRQEV 769
            .|.|..::..|.|.|.||...|...:....:..:.|||....|.....:| |:||..: .:.|..
Worm   668 VRKAYEDYANGGPTYAHLDSKEMEKVINAIEDKKKWLDEARHKQETRSKT-DAPVVFTEEILQNK 731

  Fly   770 QTLNSCVSSVINRAKPKPTPAKTATPPKDEANAEQNGGEPAANSGDKMDVD 820
            ....:.|:.::|:.|| ..||    |||.|......|.:|.:..|: ||||
Worm   732 NVFENVVNPILNKKKP-AAPA----PPKKEEPQPAAGDQPQSQPGE-MDVD 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	195/384 (51%)
Hsc70Cb	NP_001189103.1	HSP70	3..682	CDD:278441	293/688 (43%)
hsp-110	NP_498868.1	HSPA4_like_NDB	2..387	CDD:212670	195/384 (51%)
hsp-110	NP_498868.1	HSP70	3..650	CDD:278441	295/694 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167622
Domainoid	1	1.000	524	1.000	Domainoid score	I146
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1624
Inparanoid	1	1.050	576	1.000	Inparanoid score	I559
Isobase	1	0.950	-	0	Normalized mean entropy	S1071
OMA	1	1.010	-	-		QHG54058
OrthoDB	1	1.010	-	-		D285748at33208
OrthoFinder	1	1.000	-	-		FOG0001023
OrthoInspector	1	1.000	-	-		oto17551
orthoMCL	1	0.900	-	-		OOG6_100680
Panther	1	1.100	-	-	LDO	PTHR45639
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R574
SonicParanoid	1	1.000	-	-		X684
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790