DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70Cb and T24H7.2

DIOPT Version :9

Sequence 1:	NP_001189103.1	Gene:	Hsc70Cb / 39557	FlyBaseID:	FBgn0026418	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_495249.1	Gene:	T24H7.2 / 174033	WormBaseID:	WBGene00020781	Length:	925	Species:	Caenorhabditis elegans

Alignment Length:	943	Identity:	224/943 - (23%)
Similarity:	381/943 - (40%)	Gaps:	190/943 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVIGIDFGNESCYVAAARSG-GIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTV 64
            ::.:.||.|.:...:...:.| .::...|..|.|.||:.|......|....||...||.......
Worm    24 LAAMTIDLGTQFLKIGIVKPGIPMDIALNTESRRKTPNVVMIQDGHRTFADAAIGMQVRYPHLVH 88

  Fly    65 GGFKRLLGRKFNDPHVQ--------HELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAML 121
            |....|:|:....|..:        .|:...|     :...||..|:.  ||.  :..|.||||:
Worm    89 GQLNDLVGKSTQHPSFELFKRRNTFFEVDDAP-----KNASSINFKLG--GES--YTVEALTAMI 144

  Fly   122 FTKLKE-TSAAAMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYK 185
            ....|: |...|...::.|.||..||:||.|||.|:..|||:|||.||:|:|:.||.||::|.::
Worm   145 LANAKKFTEEYAQAAEIKDVVITVPVYFTPAERLAVERAAQMAGLTVLQLINDGTAAALSHGIFR 209

  Fly   186 NDLFEDKPRNVIFVDFGHSSLQASACAF--------TKGKLKMLASTWDQ-IGGRDIDLALGDYF 241
            .....:||:.::..|.|.:...|:...|        .:.|:.:|...:|: :||.::...|.|:.
Worm   210 RKEIGEKPQRLMVYDMGAAKTTATIVEFKLVKEKYEKQPKMTVLGVGFDRTLGGIEMTNRLRDHL 274

  Fly   242 AKEFQERYKINAK--TNARANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQME 304
            .:.|::.||...|  ||.||..:...|.|:||:.:|||:... ..||...:|||....:.|....
Worm   275 IEMFEKNYKPKTKVNTNRRAMTKFSKEAERLKQVLSANAEHF-AQIESAHEDIDAKLKVTREDFN 338

  Fly   305 ELCAPVLQRVEQTFKRLLAESKLQLDDIHSVEIVGGSSRIPSVKQLIEQ-VFNKPASTTLNQDEA 368
            .|.:.:..|..:..::.|..:::.:|||....::|..:|:|.|:::::: :..|.....||.|||
Worm   339 HLISDMESRFGEPIEQALRMAQIPIDDIDQFVLMGAGTRVPKVQEIVQKTIGTKEIGKFLNTDEA 403

  Fly   369 VSRGAALQCAIMSPAVRVREFGVTD-----IQNYAVKVLWDSEGSAAPGEIEIFPQ-------YH 421
            |:.||..|.|.:|...:|:.|.:.:     ::.:.|..:.|.:.....||..:...       |.
Worm   404 VAMGALFQAAHLSKGFKVKPFNIEEKVIFPVEVHFVSKIRDEKTEEITGEKNVVKTLFAANSVYP 468

  Fly   422 ASPFSRLLTINRKGPFNVSIVYGQQVPYPDQTI----------------GVWKVKDVKPTERGEG 470
            ..|.:..|| :....|:|::.||:...:..|.:                |:.:....:.:|..|.
Worm   469 THPKTISLT-SYSDDFSVALKYGKIESFTKQQVQEIGSLLDNLVDVEISGLSEALKNRSSEESEF 532

  Fly   471 QDVKLKVRINNNGIV-------------------------LISSAT-------------LVEKKE 497
            :.||:...::.:|||                         |.||.|             ..|:|.
Worm   533 KGVKVSFIVDASGIVRVRRAEALFEPKSGLVGSIASTISGLFSSKTEEGEPTTDDSTPQSTEEKT 597

  Fly   498 AEEAAAAAEQAASEEKPGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGS 562
            .|:.:...|.:..|.:|....|:|.|      |:...||.:.|.|:       |.|..||
Worm   598 EEKESVKVEDSTPEPEPETPVNSTSE------ESPKTNETEKNASS-------GNATEVK----- 644

  Fly   563 GADKKKKASKATELP----LECTTHGFSPVDLSNYTQQESK--MIGNDQKE---TERIDAKNALE 618
              :|||      |||    |..|....|....:.|..||.|  |....:||   :||...:|.||
Worm   645 --EKKK------ELPSIVRLRITNKYPSAFVPNKYDVQEEKRRMEAFAEKERLASERAAVENELE 701

  Fly   619 EFVYDMRNKLQGGPFERYVVEAEREKIVSQLNDLENWLYED-GEDCERDIYTSRLQAL------- 675
            .|.::....|:...|..|:.:.|:.|:...:..:..||.:| .:|.....:|..|..|
Worm   702 SFNFECSQYLEETEFTDYMADEEKTKLEDSVKRIRAWLEDDVTKDTPTKDFTDNLLELKNVVRSV 766

  Fly   676 -----HQKTDPIKLRA---------------SDYEQGPAAF-----DELKNSIAIARLAVAEFRK 715
                 |.|..|.||::               ::.::..|.|     |.||:.:...::.|.:.||
Worm   767 KKRQEHDKAVPEKLKSLETLLETTFSLTTLGNNVDEEKALFKKEDRDGLKSKLDKLKIWVTDVRK 831

  Fly   716 GV---PKYDHLT------ETEFINISETADKAQSWLDANLPKFTQSPRTA-DSPVQISAVRQEVQ 770
            .:   .|.|...      :|:..|::...|:...    .:.|.|.....| |..:.|..:.:|.:
Worm   832 HLDLKKKTDDFNFTGKDIDTKTKNLNREVDRFMK----KMKKITTLDDLAKDGKIDIDTIVEEAE 892

  Fly   771 TLNSCVSSVINRAKPKPTPAKTATPPKDEANAE 803
            .         .:|:......|.:|...:|:..|
Worm   893 K---------KKAEQDKKKEKKSTKKANESKVE 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	115/400 (29%)
Hsc70Cb	NP_001189103.1	HSP70	3..682	CDD:278441	197/788 (25%)
T24H7.2	NP_495249.1	HYOU1-like_NBD	27..413	CDD:212672	114/395 (29%)
T24H7.2	NP_495249.1	DnaK	29..669	CDD:223520	170/676 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810