DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70Cb and Hspa4

DIOPT Version :9

Sequence 1:	NP_001189103.1	Gene:	Hsc70Cb / 39557	FlyBaseID:	FBgn0026418	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_032326.3	Gene:	Hspa4 / 15525	MGIID:	1342292	Length:	842	Species:	Mus musculus

Alignment Length:	872	Identity:	383/872 - (43%)
Similarity:	532/872 - (61%)	Gaps:	66/872 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVIGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVG 65
            |||:|||.|.:|||||.||:|||||:||:||.|.||:.|:|..|.|.||.|||:|.::|.||||.
Mouse     1 MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACVSFGPKNRSIGAAAKSQVISNAKNTVQ 65

  Fly    66 GFKRLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSA 130
            ||||..||.|:||.|:.|.:::...:.....|..||||.|:.|:::|..||:||||.:|||||:.
Mouse    66 GFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAMLLSKLKETAE 130

  Fly   131 AAMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDL--FEDKP 193
            :.::..|.|||::.|.|:|:|||::::||.||||||.|||||||||.|||||.||.||  .|:||
Mouse   131 SVLKKPVVDCVVSVPSFYTDAERRSVMDATQIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKP 195

  Fly   194 RNVIFVDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKTNA 257
            |||:|||.|||:.|.|.|||.|||||:||:.:| .:|||..|..|.::|.:||.::||::.|:..
Mouse   196 RNVVFVDMGHSAYQVSVCAFNKGKLKVLATAFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSKI 260

  Fly   258 RANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLL 322
            ||.|||..|.|||||.||||::.|||:||||::|||||.:|.|.:..|:|..:|.|||...:.:|
Mouse   261 RALLRLSQECEKLKKLMSANASDLPLSIECFMNDIDVSGTMNRGKFLEMCDDLLARVEPPLRSVL 325

  Fly   323 AESKLQLDDIHSVEIVGGSSRIPSVKQLIEQVFNKPASTTLNQDEAVSRGAALQCAIMSPAVRVR 387
            .:|||:.:||::||||||::|||:||:.|.:.|.|..|||||.||||:||.||||||:|||.:||
Mouse   326 EQSKLKKEDIYAVEIVGGATRIPAVKEKISKFFGKELSTTLNADEAVTRGCALQCAILSPAFKVR 390

  Fly   388 EFGVTDIQNYAVKVLWDSEGSAAPGEIEIFPQYHASPFSRLLTINRKGPFNVSIVYG--QQVPYP 450
            ||.:||:..|.:.:.|:|.......:.|:||:.||:|||::||..||.||.:...|.  |.:|||
Mouse   391 EFSITDVVPYPISLRWNSPAEEGLSDCEVFPKNHAAPFSKVLTFYRKEPFTLEAYYSSPQDLPYP 455

  Fly   451 DQTIGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVE---KKEAEEAAAAAEQAASEE 512
            |..|..:.|:.|.|...|....||:|||:|.:||..:|||.|||   .:|:||.....:.|..||
Mouse   456 DPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSAALVEVHKSEESEEPMETDQNAKEEE 520

  Fly   513 K-PGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGSGADKK-------KK 569
            | ..||.....|....|.:...||:.::.....|..|.:              |||       ||
Mouse   521 KMQVDQEEPHTEEQQQQPQTPAENKAESEEMETSQAGSK--------------DKKTDQPPQAKK 571

  Fly   570 ASKAT---ELPLECTTHGFSPVD---LSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKL 628
            |...|   :||:|  :.....:|   |..||:.|.|||..|:.|.||.|||||:||:||:||:||
Mouse   572 AKVKTSTVDLPIE--SQLLWQLDREMLGLYTENEGKMIMQDKLEKERNDAKNAVEEYVYEMRDKL 634

  Fly   629 QGGPFERYVVEAEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPIKLRASDYEQGP 693
             .|.:|::|.|.:|.....:|.|.||||||||||..:.:|..:|..|.....|||.|..:.|:.|
Mouse   635 -SGEYEKFVSEDDRNTFTLKLEDTENWLYEDGEDQPKQVYVDKLAELKSLGQPIKTRFQESEERP 698

  Fly   694 AAFDELKNSIAIARLAVAEFRKGVPKYDHLTETEFINISETADKAQSWLDANLPKFTQSPRTADS 758
            ..|:||...|......::.|:....:|:||...:...:.::.::|..|:::.|....:...|.|.
Mouse   699 KLFEELGKQIQQYMKVISSFKNKEDQYEHLDAADVTKVEKSTNEAMEWMNSKLNLQNKQSLTVDP 763

  Fly   759 PVQISAVRQEVQTLNSCVSSVINRAKPKPTPAKTATPPKDE-ANAEQNGGEPAANSGDKMDVDNN 822
            .|:...:..:::.|.|..|.:|::.|||      ..|||:| .:|||||  |....|     ||.
Mouse   764 VVKTKEIEAKIKELTSICSPIISKPKPK------VEPPKEEPKHAEQNG--PVDGQG-----DNP 815

  Fly   823 GQSAA--GND-----------PSMEVE 836
            |..||  |.|           |.|:::
Mouse   816 GSQAAEHGADTAVPSDGDKKLPEMDID 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	214/381 (56%)
Hsc70Cb	NP_001189103.1	HSP70	3..682	CDD:278441	334/700 (48%)
Hspa4	NP_032326.3	HSPA4_NBD	2..384	CDD:212687	214/381 (56%)
		HSP70	3..609	CDD:278441	297/621 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..577		21/90 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	784..842		24/70 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847003
Domainoid	1	1.000	624	1.000	Domainoid score	I178
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1624
Inparanoid	1	1.050	678	1.000	Inparanoid score	I718
Isobase	1	0.950	-	0	Normalized mean entropy	S1071
OMA	1	1.010	-	-		QHG54058
OrthoDB	1	1.010	-	-		D285748at33208
OrthoFinder	1	1.000	-	-		FOG0001023
OrthoInspector	1	1.000	-	-		otm42371
orthoMCL	1	0.900	-	-		OOG6_100680
Panther	1	1.100	-	-	LDO	PTHR45639
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R574
SonicParanoid	1	1.000	-	-		X684
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750