DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70Cb and Hspa1b

DIOPT Version :9

Sequence 1:	NP_001189103.1	Gene:	Hsc70Cb / 39557	FlyBaseID:	FBgn0026418	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_034608.2	Gene:	Hspa1b / 15511	MGIID:	99517	Length:	642	Species:	Mus musculus

Alignment Length:	702	Identity:	198/702 - (28%)
Similarity:	343/702 - (48%)	Gaps:	98/702 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SVIGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVGG 66
            :.||||.|.....|...:.|.:|.:|||...|.|||:|||...:|:||.|||||...|.:|||..
Mouse     5 TAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFD 69

  Fly    67 FKRLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSAA 131
            .|||:||||.|..||.::...|.:|...|| ...::|||.||.:.|.||::::|:.||:||.:.|
Mouse    70 AKRLIGRKFGDAVVQSDMKHWPFQVVNDGD-KPKVQVNYKGESRSFFPEEISSMVLTKMKEIAEA 133

  Fly   132 AMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDLFEDKPRNV 196
            .:...|.:.||..|.:|.:::|:|..||..||||||||::||.||.|:|||..:....|   |||
Mouse   134 YLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGE---RNV 195

  Fly   197 IFVDFGHSSLQASACAFTKGKLKMLASTWD-QIGGRDIDLALGDYFAKEFQERYKINAKTNARAN 260
            :..|.|..:...|......|..::.|:..| .:||.|.|..|..:|.:||:.::|.:...|.||.
Mouse   196 LIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAV 260

  Fly   261 LRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLLAES 325
            .||.|..|:.|:.:| :||:..|.|:...:.||..:|:.|::.||||:.:.:...:..::.|.::
Mouse   261 RRLRTACERAKRTLS-SSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRGTLEPVEKALRDA 324

  Fly   326 KLQLDDIHSVEIVGGSSRIPSVKQLIEQVFN-KPASTTLNQDEAVSRGAALQCAIM--SPAVRVR 387
            |:....||.:.:||||:|||.|::|::..|| :..:.::|.||||:.|||:|.||:  ..:..|:
Mouse   325 KMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQ 389

  Fly   388 EFGVTDIQNYAVKVLWDSEGSAAPGEIE---IFPQYHASPFSRLLTINRKGPFNVSIVYGQQVPY 449
            :..:.|:...::.:  ::.|......|:   ..|......|: ..:.|:.|.. :.:..|::...
Mouse   390 DLLLLDVAPLSLGL--ETAGGVMTALIKRNSTIPTKQTQTFT-TYSDNQPGVL-IQVYEGERAMT 450

  Fly   450 PDQT-IGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAEEAAAAAEQAASEEK 513
            .|.. :|.:::..:.|..||..| :::...|:.|||:
Mouse   451 RDNNLLGRFELSGIPPAPRGVPQ-IEVTFDIDANGIL---------------------------- 486

  Fly   514 PGDQTNNTGEPADGQQEAYCENEDDNNTSTASSPGGQGWAQRVKGWFGSGADKKKKASKATELPL 578
                                     |.|:|..|.|                       ||.::.:
Mouse   487 -------------------------NVTATDKSTG-----------------------KANKITI 503

  Fly   579 ECTTHGFSPVDLSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQGGPFERYVVEAERE 643
            .......|..::....|:..:....|:.:.:|:.||||||.:.::|::.::....:..:.||:::
Mouse   504 TNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKK 568

  Fly   644 KIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPIKLRASDYEQGPAA 695
            |::.:..::.:|| :.....:::.:..:.:.|.:...||   .|...||..|
Mouse   569 KVLDKCQEVISWL-DSNTLADKEEFVHKREELERVCSPI---ISGLYQGAGA 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	149/382 (39%)
Hsc70Cb	NP_001189103.1	HSP70	3..682	CDD:278441	192/686 (28%)
Hspa1b	NP_034608.2	PTZ00009	1..642	CDD:240227	198/702 (28%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	2..386		149/385 (39%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	149/379 (39%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	394..509		25/195 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	617..642		198/702 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846997
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740