DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsc70Cb and Hsph1

DIOPT Version :9

Sequence 1:	NP_001189103.1	Gene:	Hsc70Cb / 39557	FlyBaseID:	FBgn0026418	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	XP_006504979.1	Gene:	Hsph1 / 15505	MGIID:	105053	Length:	877	Species:	Mus musculus

Alignment Length:	825	Identity:	347/825 - (42%)
Similarity:	499/825 - (60%)	Gaps:	44/825 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SFVAFDGKKRIIGVAAKNQQVTNMKNTVGGFKRLLGRKFNDPHVQHELTSIPARVEARGDGSIGI 101
            |.::|..|.|.|||||||||:|:..|||..|||..||.||||.:|.|..::...:....:|.:||
Mouse    56 SVISFGSKNRTIGVAAKNQQITHANNTVSSFKRFHGRAFNDPFIQKEKENLSYDLVPMKNGGVGI 120

  Fly   102 KVNYLGEDQHFGPEQLTAMLFTKLKETSAAAMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLN 166
            ||.|:.|:..|..||:||||.||||||:...::..|.||||:.|.|||:|||:::||||||.|||
Mouse   121 KVMYMDEEHFFSVEQITAMLLTKLKETAENNLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLN 185

  Fly   167 VLRLMNETTATALAYGFYKNDL--FEDKPRNVIFVDFGHSSLQASACAFTKGKLKMLASTWDQ-I 228
            .|||||:.||.||.||.||.||  .|:|||.|:|||.||||.|.|||||.|||||:|.:.:|. :
Mouse   186 CLRLMNDMTAVALNYGIYKQDLPNAEEKPRVVVFVDMGHSSFQVSACAFNKGKLKVLGTAFDPFL 250

  Fly   229 GGRDIDLALGDYFAKEFQERYKINAKTNARANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDID 293
            ||::.|..|.::|..||:.:||::||:..||.|||..|.|||||.||:|||.||||||||::|.|
Mouse   251 GGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLHQECEKLKKLMSSNSTDLPLNIECFMNDKD 315

  Fly   294 VSSSMQRSQMEELCAPVLQRVEQTFKRLLAESKLQLDDIHSVEIVGGSSRIPSVKQLIEQVFNKP 358
            ||..|.|||.|||||.:||::|.....|:|:::|:.:|:.::|||||::|||:||:.|.:.|.|.
Mouse   316 VSGKMNRSQFEELCAELLQKIEVPLHSLMAQTQLKAEDVSAIEIVGGATRIPAVKERIAKFFGKD 380

  Fly   359 ASTTLNQDEAVSRGAALQCAIMSPAVRVREFGVTDIQNYAVKVLWDSEGSAAPGEIEIFPQYHAS 423
            .|||||.||||:||.||||||:|||.:||||.|||...:.:.::|:.:.....|..|:|.:.||:
Mouse   381 VSTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLVWNHDSEETEGVHEVFSRNHAA 445

  Fly   424 PFSRLLTINRKGPFNVSIVYG--QQVPYPDQTIGVWKVKDVKPTERGEGQDVKLKVRINNNGIVL 486
            |||::||..|:|||.:...|.  |.||||:..||.:.|::|...:.||...||:|||:|.:||..
Mouse   446 PFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQNVSAQKDGEKSRVKVKVRVNTHGIFT 510

  Fly   487 ISSATLVEKKEAEE---AAAAAEQAASEEKPGDQTNNTGEPADGQQEAYCEN--EDDNNTSTASS 546
            ||:|::|||...||   ::..|:.....::|.:.::..........||..:.  :.|...::.|.
Mouse   511 ISTASMVEKVPTEEEDGSSLEADMECPNQRPTESSDVDKNIQQDNSEAGTQPQVQTDGQQTSQSP 575

  Fly   547 PGGQGWAQRVKGWFGSGADKKK-----KASKA------TELPLECTTHGFSPVDLSN-YTQQESK 599
            |..:..::..|......|::||     :|.|.      .|||:|.........||.| |.:.|.|
Mouse   576 PSPELTSEESKTPDADKANEKKVDQPPEAKKPKIKVVNVELPVEANLVWQLGRDLLNMYIETEGK 640

  Fly   600 MIGNDQKETERIDAKNALEEFVYDMRNKLQGGPFERYVVEAEREKIVSQLNDLENWLYEDGEDCE 664
            ||..|:.|.||.|||||:||.||:.|:|| .||:|:::.|.|.||.:..|.:.|:||||:|||..
Mouse   641 MIMQDKLEKERNDAKNAVEECVYEFRDKL-CGPYEKFICEQEHEKFLRLLTETEDWLYEEGEDQA 704

  Fly   665 RDIYTSRLQALHQKTDPIKLRASDYEQGPAAFDELKNSIAIARLAVAEFRKGVPKYDHLTETEFI 729
            :..|..:|:.|.:...|:|:|..:.|:.|...:||...:.......|:||....||:|:.|:|..
Mouse   705 KQAYIDKLEELMKMGTPVKVRFQEAEERPKVLEELGQRLQHYAKIAADFRGKDEKYNHIDESEMK 769

  Fly   730 NISETADKAQSWLDANLPKFTQSPRTADSP--VQISAVRQEVQTLNSCVSSVINRAKPK-PTPAK 791
            .:.::.::...|:  |.....|:.|:.|..  |:...:|.:|:.||:....|:.:.||| .:|..
Mouse   770 KVEKSVNEVMEWM--NNVMNAQAKRSLDQDPVVRTHEIRAKVKELNNVCEPVVTQPKPKIESPKL 832

  Fly   792 TATP------PKDEANAEQN-GGEPAANSGD---------KMDVD 820
            ..||      .|::...:.| |.|....:|:         .||:|
Mouse   833 ERTPNGPNIDKKEDLEGKNNLGAEAPHQNGECHPNEKGSVNMDLD 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	194/346 (56%)
Hsc70Cb	NP_001189103.1	HSP70	3..682	CDD:278441	307/666 (46%)
Hsph1	XP_006504979.1	NBD_sugar-kinase_HSP70_actin	56..403	CDD:388382	194/346 (56%)
		FtsN	<537..>620	CDD:225629	15/82 (18%)
		DUF4127	<673..761	CDD:379257	28/87 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847002
Domainoid	1	1.000	624	1.000	Domainoid score	I178
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	678	1.000	Inparanoid score	I718
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54058
OrthoDB	1	1.010	-	-		D285748at33208
OrthoFinder	1	1.000	-	-		FOG0001023
OrthoInspector	1	1.000	-	-		otm42371
orthoMCL	1	0.900	-	-		OOG6_100680
Panther	1	1.100	-	-	O	PTHR45639
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R574
SonicParanoid	1	1.000	-	-		X684
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800