DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70Cb and HSPA12B

DIOPT Version :9

Sequence 1:	NP_001189103.1	Gene:	Hsc70Cb / 39557	FlyBaseID:	FBgn0026418	Length:	836	Species:	Drosophila melanogaster
Sequence 2:	NP_443202.3	Gene:	HSPA12B / 116835	HGNCID:	16193	Length:	686	Species:	Homo sapiens

Alignment Length:	716	Identity:	125/716 - (17%)
Similarity:	202/716 - (28%)	Gaps:	295/716 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VIGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVGGF 67
            |:.||||..|       ||...:.|:|                        .:.:..|:...||
Human    62 VVAIDFGTTS-------SGYAFSFASD------------------------PEAIHMMRKWEGG- 94

  Fly    68 KRLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQH--FGPEQLTAMLF-------- 122
                     ||.|.|:.|  |..:....:|:.. ...|...|.:  ..||:....|:
Human    95 ---------DPGVAHQKT--PTCLLLTPEGAFH-SFGYTARDYYHDLDPEEARDWLYFEKFKMKI 147

  Fly   123 --------------------------------------TKLKETSAAAMQTQVNDCVIACPVFFT 149
                                                  .:|:|.|.:..:......|:..|..:.
Human   148 HSATDLTLKTQLEAVNGKTMPALEVFAHALRFFREHALQELREQSPSLPEKDTVRWVLTVPAIWK 212

  Fly   150 NAERKALLDAAQIAGL----------------------NVLRL---------------MNETTAT 177
            ...::.:.:||.:|||                      ..|||               :.|..:.
Human   213 QPAKQFMREAAYLAGLVSRENAEQLLIALEPEAASVYCRKLRLHQLLDLSGRAPGGGRLGERRSI 277

  Fly   178 ALAYGFYKNDLFEDKPRNVIFVDFGHSSLQASACAFTK----------------------GKLKM 220
            ..::...:..|...:......|:.|...|.|...|..:                      |.||.
Human   278 DSSFRQAREQLRRSRHSRTFLVESGVGELWAEMQAGDRYVVADCGGGTVDLTVHQLEQPHGTLKE 342

  Fly   221 L-ASTWDQIGGRDIDLALGDYFAKEFQERYKINAKTNARANLRLLTEIEKLKKQMSANSTKLPLN 284
            | .::....|...:|||......:.|.|.:....|....|....||...:.:|:.:.......||
Human   343 LYKASGGPYGAVGVDLAFEQLLCRIFGEDFIATFKRQRPAAWVDLTIAFEARKRTAGPHRAGALN 407

  Fly   285 IECFLDDID---------VSSSMQRSQ------------------MEELCAPVLQRVEQTFKRLL 322
            |......||         |.::::||.                  |.||..|.:..:.|..:.||
Human   408 ISLPFSFIDFYRKQRGHNVETALRRSSVNFVKWSSQGMLRMSCEAMNELFQPTVSGIIQHIEALL 472

  Fly   323 AESKLQLDDIHSVEIVGGSSRIPSVKQLIEQVFNKPASTTLNQDEAVSRGAALQCAIMSPAVRV- 386
            |..::|  .:..:.:|||.:.                |..|..        |:|.|:.:..:||
Human   473 ARPEVQ--GVKLLFLVGGFAE----------------SAVLQH--------AVQAALGARGLRVV 511

  Fly   387 --REFGVTDIQNYAVKVLWDSEGSAAPGEIEIFPQYHASPFSRLLTINRKGPFNVSIVYGQQVPY 449
              .:.|:|.::.   .||:    ..|||.:.:                |:.|    :.||
Human   512 VPHDVGLTILKG---AVLF----GQAPGVVRV----------------RRSP----LTYG----- 544

  Fly   450 PDQTIGVWK--VKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAEEAAAAAEQAASEE 512
                :||..  |....|.|       ||.||.......           :..|...||||:.:
Human   545 ----VGVLNRFVPGRHPPE-------KLLVRDGRRWCT-----------DVFERFVAAEQSVA-- 585

  Fly   513 KPGDQTNNTGEPA-DGQQEAY-----CENED----------------------DNNTSTASSPGG 549
             .|::...:..|| .||:...     |..||                      |....||.:|.|
Human   586 -LGEEVRRSYCPARPGQRRVLINLYCCAAEDARFITDPGVRKCGALSLELEPADCGQDTAGAPPG 649

  Fly   550 Q 550
            :
Human   650 R 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	85/512 (17%)
Hsc70Cb	NP_001189103.1	HSP70	3..682	CDD:278441	125/716 (17%)
HSPA12B	NP_443202.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	12..53
HSPA12B	NP_443202.3	NBD_sugar-kinase_HSP70_actin	61..529	CDD:327376	91/543 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900