DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6661 and ALDH1A2

DIOPT Version :9

Sequence 1:	NP_648686.3	Gene:	CG6661 / 39556	FlyBaseID:	FBgn0036403	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_003879.2	Gene:	ALDH1A2 / 8854	HGNCID:	15472	Length:	518	Species:	Homo sapiens

Alignment Length:	563	Identity:	129/563 - (22%)
Similarity:	229/563 - (40%)	Gaps:	89/563 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 EVEPDSQPAEENPSIH-----------RNQRVLVNHAIQEIQHRPLEVPTIIGDDTVYTMDT-QR 101
            ||:.|  ||....|:|           :..::.:|:..|..:...: .|       ||...| ::
Human    11 EVKAD--PAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRV-FP-------VYNPATGEQ 65

  Fly   102 VCCPHHLQTNLAHVYYANRKQIEAAIKS---ALSAQGTWSLVPIAQRLAIWRRAATIIEEDELRL 163
            ||          .|..|::..|:.|:::   |.|....|..:..::|..:..:.|.::|.|...|
Human    66 VC----------EVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL 120

  Fly   164 RVFLMMTLSKTADDATR-DIRRLLTSLRANADYLEHLSELRFEIQGDMNVFPSFHLRPMDGFVAA 227
            .....:...|....|.. |::.::.:.|..|.:.:.:..:...:.||...|...  .|: |....
Human   121 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRH--EPI-GVCGQ 182

  Fly   228 LAPFESVALSSSLALCPAL-MGNTVLWNPSLEVAPVSYLIFRA-FQEAGLPSGVINFVPANERLF 290
            :.|:....|..:..:.||| .||||:..|: |..|:|.|...| .:|||.|.||||.:|
Human   183 IIPWNFPLLMFAWKIAPALCCGNTVVIKPA-EQTPLSALYMGALIKEAGFPPGVINILP------ 240

  Fly   291 LDTITDAVHFAGLNTQASAAFYRH-------------VHKLVSDRMERYICFPRLVAECPGQNFH 342
                       |....|.||...|             |.||:.:...| ....|:..|..|::.:
Human   241 -----------GYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGR-SNLKRVTLELGGKSPN 293

  Fly   343 FVHASAKVESVVSATVQAAFGFAGQYANSLSRMYVPSSMWPRLREELVEATEQLTIGDPIESETD 407
            .:.|.|.::..|....|..|...||...:.||::|..|::.......||..::..:|.|.:..|:
Human   294 IIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTE 358

  Fly   408 IGAMVHINDFRRMQKLLQR--TKNMEQLCGGSCDDSTGRFVDPTIV-RVSDPLDPLLCEPCCGPF 469
            .|..:....:.::.:|:|.  .:..:..|||......|.|::||:. .|:|.: .:..|...||.
Human   359 QGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDM-RIAKEEIFGPV 422

  Fly   470 LPVFVYSDDSFSEALKLAANQSRYALSGSIFASQDEVILHCLNQLRMSASNLYVNERCTGSTYGL 534
            ..:..:.  :..|.:: .||.|.:.|..::|.:.....|...:  .|.|..:::|  |..:....
Human   423 QEILRFK--TMDEVIE-RANNSDFGLVAAVFTNDINKALTVSS--AMQAGTVWIN--CYNALNAQ 480

  Fly   535 TPFGGNRLSGTNDKSGSAYFLMRWSSPLLIEETVDGPPPMRGS 577
            :||||.::||...:.|.  |.:|..|.:   :||....|.:.|
Human   481 SPFGGFKMSGNGREMGE--FGLREYSEV---KTVTVKIPQKNS 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6661	NP_648686.3	ALDH-SF	68..567	CDD:299846	118/521 (23%)
ALDH1A2	NP_003879.2	ALDH_F1AB_F2_RALDH1	32..512	CDD:143459	120/532 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810