Protein Alignment CG6661 and ALDH5A1

DIOPT Version :9

• Sequence 1: NP_648686.3
• Gene: CG6661 / 39556
• FlyBaseID: FBgn0036403
• Length: 581
• Species: Drosophila melanogaster
• Sequence 2: NP_733936.1
• Gene: ALDH5A1 / 7915
• HGNCID: 408
• Length: 548
• Species: Homo sapiens
• Alignment Length: 467
• Identity: 105/467 - (22%)
• Similarity: 185/467 - (39%)
• Gaps: 64/467 - (13%)

  Fly   121 KQIEAAIKSALSAQGTWSLVPIAQRLAIWRRAATIIEEDELRLRVFLMMTLSKTADDATRDIRRL 185
            ::..||:::|..|...|..|...:|.::.|:...::.:::..|...:.....|...:|..:|
Human    96 REARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEI--- 157

  Fly   186 LTSLRANADYLEHLSELRFEIQGDMNVFP-----SFHLRPMDGFVAALAP--FESVALSSSLALC 243
                ..:|.:||..||....:.||:...|     :..|:...|..|.:.|  |.|..::..:...
Human   158 ----LYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAA 218

  Fly   244 PALMGNTVLWNPSLEVAPVSYL----IFRAF----------QEAGLPSGVINFVPAN-------- 286
            .| .|.||:..|: |..|.|.|    :.:.|          .:||:||||.|.:|.:
Human   219 LA-AGCTVVVKPA-EDTPFSALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVG 281

  Fly   287 ERLFLDTITDAVHFAGLNTQASAAFYRHVHKLVSDRMERYICFPRLVAECPGQNFHFVHASAKVE 351
            |.:..|.:...:.|.|..|......:...:.:           .|:..|..|.....|..||.|:
Human   282 EAICTDPLVSKISFTGSTTTGKILLHHAANSV-----------KRVSMELGGLAPFIVFDSANVD 335

  Fly   352 SVVSATVQAAFGFAGQYANSLSRMYVPSSMWPRLREELVEATEQ-LTIGDPIESETDIGAMVHIN 415
            ..|:..:.:.|...||.....::..|...:.....:...||.:: |.:|:..|..|..|.:::..
Human   336 QAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEK 400

  Fly   416 DFRRMQKLLQR--TKNMEQLCGGSCDDSTGRFVDPTIVRVSDPLDPLLC--EPCCGPFLPVFVYS 476
            ...:::|.:..  :|....:.||........|.:||:  :.:....:||  |...||..||..:
Human   401 AVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTL--LCNVTQDMLCTHEETFGPLAPVIKF- 462

  Fly   477 DDSFSEALKLAANQSRYALSGSIFASQDEVILHCLNQLRMSASNLYVNERCTGSTYGLTPFGGNR 541
             |:..||:.: ||.:...|:|..::.....|.....||.:..  :.|||....|..  .||||.:
Human   463 -DTEEEAIAI-ANAADVGLAGYFYSQDPAQIWRVAEQLEVGM--VGVNEGLISSVE--CPFGGVK 521

  Fly   542 LSGTNDKSGSAY 553
            .||.. :.||.|
Human   522 QSGLG-REGSKY 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6661	NP_648686.3	ALDH-SF	68..567	CDD:299846	105/467 (22%)
ALDH5A1	NP_733936.1	SSADH	78..541	CDD:188167	105/467 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900