DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6661 and Aldh4a1

DIOPT Version :9

Sequence 1:	NP_648686.3	Gene:	CG6661 / 39556	FlyBaseID:	FBgn0036403	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001128170.1	Gene:	Aldh4a1 / 641316	RGDID:	1624206	Length:	562	Species:	Rattus norvegicus

Alignment Length:	513	Identity:	189/513 - (36%)
Similarity:	302/513 - (58%)	Gaps:	20/513 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 QRVLVNHAIQEIQHRPLEVPTIIGDDTVYTMDTQRVCCPHHLQTNLAHVYYANRKQIEAAIKSAL 131
            :|..:..|:.:::.:...:|.::||:.|:|.|.:....|.:....:|...||::..:..||::|:
  Rat    45 ERDALQKALNDLKDQTEAIPCVVGDEEVWTSDVRYQLSPFNHGHKVAKFCYADKALLNKAIEAAV 109

  Fly   132 SAQGTWSLVPIAQRLAIWRRAATIIEEDELRLRVF--LMMTLSKTADDATRD-IRRLLTSLRANA 193
            .|:..|.|.|:|.|..|:.:||.::.... |..:.  .|:...||...|..| ...|:...|.||
  Rat   110 LARKEWDLKPVADRAQIFLKAADMLSGPR-RAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNA 173

  Fly   194 DYLEHLSELRFEIQGD--MNVFPSFH---LRPMDGFVAALAPFESVALSSSLALCPALMGNTVLW 253
            .:       ..|::|:  ::|.||.:   .|.::|||||::||...|:..:||..||||||.|||
  Rat   174 KF-------AVELEGEQPISVPPSTNHVVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLW 231

  Fly   254 NPSLEVAPVSYLIFRAFQEAGLPSGVINFVPANERLFLDTITDAVHFAGLNTQASAAFYRHVHKL 318
            .||......||.::|..:|||||..||.||||:...|.||:|.:.|..|:|...|...::|:.|.
  Rat   232 KPSDTAMLASYAVYRILREAGLPPNVIQFVPADGPTFGDTVTSSEHLCGINFTGSVPTFKHLWKQ 296

  Fly   319 VSDRMERYICFPRLVAECPGQNFHFVHASAKVESVVSATVQAAFGFAGQYANSLSRMYVPSSMWP 383
            |:..::|:..||||..||.|:||||||:||.|:||||.|:::||.:.||..::.||:|||.|:||
  Rat   297 VAQNLDRFRTFPRLAGECGGKNFHFVHSSADVDSVVSGTLRSAFEYGGQKCSACSRLYVPQSLWP 361

  Fly   384 RLREELVEATEQLTIGDPIES-ETDIGAMVHINDFRRMQKLLQRTK---NMEQLCGGSCDDSTGR 444
            :::..|:|...::.:|:|.|. .|...|::....|.|::|.|:..:   ::..|.||.|::|.|.
  Rat   362 QIKGRLLEEHSRIKVGNPAEDFGTFFSAVIDAKAFARIKKWLEHARSSPSLSILAGGQCNESVGY 426

  Fly   445 FVDPTIVRVSDPLDPLLCEPCCGPFLPVFVYSDDSFSEALKLAANQSRYALSGSIFASQDEVILH 509
            ||:|.|:...||.:|::.|...||.|.|:||.|:.:.|.|:|..:.:.|.|:|::||....::..
  Rat   427 FVEPCIIESKDPQEPIMKEEIFGPVLTVYVYPDEKYRETLQLVDSTTSYGLTGAVFAQDKTIVQE 491

  Fly   510 CLNQLRMSASNLYVNERCTGSTYGLTPFGGNRLSGTNDKSGSAYFLMRWSSPLLIEET 567
            ....||.:|.|.|:|::.|||..|..||||.|.||||||.|..::::||:||.:|:||
  Rat   492 ATRMLRNAAGNFYINDKSTGSVVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKET 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6661	NP_648686.3	ALDH-SF	68..567	CDD:299846	187/510 (37%)
Aldh4a1	NP_001128170.1	ALDH_F4-17_P5CDH	31..552	CDD:143441	189/513 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D293592at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920