DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6661 and Aldh9a1

DIOPT Version :9

Sequence 1:	NP_648686.3	Gene:	CG6661 / 39556	FlyBaseID:	FBgn0036403	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_064377.2	Gene:	Aldh9a1 / 56752	MGIID:	1861622	Length:	518	Species:	Mus musculus

Alignment Length:	527	Identity:	112/527 - (21%)
Similarity:	209/527 - (39%)	Gaps:	87/527 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 IHRNQRVLVNHAIQEIQHRPL--------EVPTIIGDDTVYTMDTQRVCCPHHLQTNLAHVYYAN 119
            |||...|........:..:||        |.....|.:..:...|.||         :|....:.
Mouse    16 IHRAAAVAAMSTGTFVVSQPLNYRGGARVEPVDASGTEKAFEPATGRV---------IATFACSG 71

  Fly   120 RKQIEAAIKSALSAQGTWSLVPIAQRLAIWRRAATIIEEDELRLRVFLMMTLSKTADDATRDIRR 184
            .|::..|:::|.:|...||.....:|..:...||.||:|.:..:.....:...|:..:|..|:..
Mouse    72 EKEVNLAVENAKAAFKLWSKKSGLERCQVLLEAARIIKERKDEIATVETINNGKSIFEARLDVDT 136

  Fly   185 LLTSLRANADYLEHLSELRFEIQGDMNVFPSFHLRPMD---GFVAALAPFESVALSSSLALCPAL 246
            ....|...|.....::....::.|  ..|......|:.   |..|...||:.....|:.||.
Mouse   137 CWQCLEYYAGLAASMAGEHIQLPG--GSFGYTRREPLGVCVGIGAWNYPFQIACWKSAPALA--- 196

  Fly   247 MGNTVLWNPSLEVAPVSYLIF-RAFQEAGLPSGVINFVPANERLFLDTITDAVHFAGLNTQASAA 310
            .||.:::.|| ...|||.|:. ..:.:||.|.|:.|.|.                .|..|.....
Mouse   197 CGNAMIFKPS-PFTPVSALLLAEIYTKAGAPPGLFNVVQ----------------GGAATGQFLC 244

  Fly   311 FYRHVHKL-----------VSDRMERYICFPRLVAECPGQNFHFVHASAKVESVVSATVQAAFGF 364
            .:|.|.|:           :.:...:.:  ..:..|..|::...:.:...:|:.|...:.|.|..
Mouse   245 HHREVAKISFTGSVPTGVKIMEMSAKGV--KPITLELGGKSPLIIFSDCNMENAVKGALMANFLT 307

  Fly   365 AGQYANSLSRMYVPSSMWPRLREELVEATEQLTIGDPIESETDIGAMVHINDFRRMQKLLQRTKN 429
            .||...:.:|::|...:..:...|:|:.|:::.:|||:..:|.:|.:::.....|:...::..|
Mouse   308 QGQVCCNGTRVFVQKEIADKFINEVVKQTQKIKLGDPLLEDTRMGPLINAPHLERVLGFVKLAK- 371

  Fly   430 MEQ----LCGGSC---DD---STGRFVDPTIVRVSDPLDPLLC--EPCCGPFLPVFVYSDDSFSE 482
             ||    ||||..   :|   ..|.::.|.|  :::..|.:.|  |...||.:.:..:..:  :|
Mouse   372 -EQGATVLCGGEVYVPEDPKLKHGYYMTPCI--LTNCRDDMTCVKEEIFGPVMSILTFGTE--AE 431

  Fly   483 ALKLAANQSRYALSGSIFASQDEVILHCLNQLRMSASNLYVNERCTGSTYGLT----PFGGNRLS 543
            .|: .||.:.:.|:..:| ::|....|.: ...:.|...|:|      .|.::    ||||.:.|
Mouse   432 VLE-RANDTTFGLAAGVF-TRDIQRAHRV-AAELQAGTCYIN------NYNVSPVELPFGGYKKS 487

  Fly   544 GTNDKSG 550
            |...::|
Mouse   488 GFGRENG 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6661	NP_648686.3	ALDH-SF	68..567	CDD:299846	109/522 (21%)
Aldh9a1	NP_064377.2	ALDH_F9_TMBADH	55..512	CDD:143409	104/488 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810