DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6661 and aldh8a1

DIOPT Version :9

Sequence 1:	NP_648686.3	Gene:	CG6661 / 39556	FlyBaseID:	FBgn0036403	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001004540.1	Gene:	aldh8a1 / 447801	ZFINID:	ZDB-GENE-040912-3	Length:	487	Species:	Danio rerio

Alignment Length:	463	Identity:	114/463 - (24%)
Similarity:	198/463 - (42%)	Gaps:	70/463 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 KQIEAAIKSALSAQGTWSLVPIAQRLAIWRRAATIIEEDELRLRVFLM---------MTLSKTAD 176
            :::.||:::|..|...||....|.|..:..:.|.:|   |.||..|:.         :|.::..
Zfish    45 EEVNAAVRAAKEAFPDWSAKSPADRSKVLNKLADLI---EARLEEFVQAESKDQGKTITFARNV- 105

  Fly   177 DATRDIRRLLTSLRANA-DYLEHLSEL-RFEIQGDMNVFPSFHLRPMDGFVAALAPFESVALSSS 239
                ||.|...:.|..| ..|.|.::. :.:..|.:|    :.:|...|....::|:.......:
Zfish   106 ----DIPRSAYNFRFFASSVLHHTNDCSQMDHMGCLN----YTIRCPVGVAGLISPWNLPLYLLT 162

  Fly   240 LALCPAL-MGNTVLWNPSLEVAPVSYLIFRAFQEAGLPSGVINFV-----PANERLFLDTITDAV 298
            ..:.||: .||||:..||...:..::::.:..:|||.|.||:|.|     .|.:.|........:
Zfish   163 WKIAPAVATGNTVVAKPSEMTSVTAWMMCQLLEEAGFPPGVVNIVFGTGPRAGDALVSHPDVPLI 227

  Fly   299 HFAGLNTQASAAFYRHVHKLVSDRMERYICFPRLVAECPGQNFHFVHASAKVESVVSATVQAAFG 363
            .|.|....|         :|:::|...: | .:|..|..|:|...:.|.|.:|..:|.||:::|.
Zfish   228 SFTGSTATA---------RLITERSAPH-C-KKLSLELGGKNPAIIFADADMEQCISTTVRSSFS 281

  Fly   364 FAGQYANSLSRMYVPSSMWPRLREELVEATEQLTIGDPIESETDIGAMVHINDFRRMQKLLQRTK 428
            ..|:.....||::|..|::|......||||.:...|.|.:...|.||::       .::.||:.|
Zfish   282 NQGEICLCTSRIFVERSVYPEFLTRFVEATRRWKTGVPSDPSNDNGALI-------SKEHLQKVK 339

  Fly   429 NMEQL---------CGGSCD-------DSTGRFVDPTIVRVSDPLDPLLCEPCCGPFLPVFVYSD 477
            ....|         ||...|       :..|.|:.|||:........|:.|...||...|..:.:
Zfish   340 GYITLALAEGAQVHCGEGVDKLALPQQNIGGYFMLPTIISGVKDSSALMQEEIFGPVTCVTPFDE 404

  Fly   478 DSFSEALKLAANQSRYALSGSIFASQDEVILHCLNQLRMSASNLYVNERCTGSTYGLTPFGGNRL 542
            :   |.:...||..||.||.::: |:|...:|.:.: ::.|..::.|  |........||||.:.
Zfish   405 E---EEVISRANNVRYGLSATVW-SRDVGRVHRVAR-KLQAGLVWTN--CWLVRDLNLPFGGMKH 462

  Fly   543 SGTNDKSG 550
            ||...:.|
Zfish   463 SGIGREGG 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6661	NP_648686.3	ALDH-SF	68..567	CDD:299846	114/463 (25%)
aldh8a1	NP_001004540.1	ALDH_F8_HMSADH	27..485	CDD:143412	114/463 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810