DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6661 and aldh4a1

DIOPT Version :9

Sequence 1:	NP_648686.3	Gene:	CG6661 / 39556	FlyBaseID:	FBgn0036403	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_957452.1	Gene:	aldh4a1 / 394133	ZFINID:	ZDB-GENE-040426-1179	Length:	556	Species:	Danio rerio

Alignment Length:	529	Identity:	193/529 - (36%)
Similarity:	307/529 - (58%)	Gaps:	19/529 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 VEPDSQPAEENPSIHRNQRVLVNHAIQEIQHRPLEVPTIIGDDTVYTMDTQRVCCPHHLQTNLAH 114
            ||..::|..|... ...:|..:..|::.::.:..|:|.:||::.|:|.|.:....|.:....:|.
Zfish    23 VEVKNEPVLEFKE-GSKERAELEEALRNLKGKTEEIPCVIGNEEVWTKDIRFQLSPFNHSHQVAK 86

  Fly   115 VYYANRKQIEAAIKSALSAQGTWSLVPIAQRLAIWRRAATIIEEDELRLRVF--LMMTLSKTADD 177
            ..||::..:..||:::::|:..|.|.|::.|..|:.:||.||...: |..|.  .|:...||...
Zfish    87 FCYADKDLLNKAIEASVAARREWDLKPVSDRAQIFFKAADIISGPK-RAEVLAKTMIGQGKTVVQ 150

  Fly   178 ATRDIR-RLLTSLRANADYLEHLSELR----FEIQGDMNVFPSFHLRPMDGFVAALAPFESVALS 237
            |..|.. .|:...|.||   :|..||.    .:..|..|   :...|.::|||||:|||...|:.
Zfish   151 AEIDAAPELIDFFRFNA---KHAIELEDQQPLDSDGSTN---TMLYRGLEGFVAAVAPFNFTAIG 209

  Fly   238 SSLALCPALMGNTVLWNPSLEVAPVSYLIFRAFQEAGLPSGVINFVPANERLFLDTITDAVHFAG 302
            .:||..||||||.|||.||......||.:::..:|:|||..:|.||||:..:|.||:|.:.|.||
Zfish   210 GNLAGTPALMGNVVLWKPSDTAMSASYAVYKILRESGLPPNIIQFVPADGPVFGDTVTSSEHLAG 274

  Fly   303 LNTQASAAFYRHVHKLVSDRMERYICFPRLVAECPGQNFHFVHASAKVESVVSATVQAAFGFAGQ 367
            :|...|...::.:.|.|:..::.|..|||:..||.|:||||||.||.|.|||:.|:::||.:.||
Zfish   275 INFTGSVPTFKRLWKQVAQNLDIYKNFPRVAGECGGKNFHFVHKSADVRSVVTGTIRSAFEYGGQ 339

  Fly   368 YANSLSRMYVPSSMWPRLREELVEATEQLTIGDPIES-ETDIGAMVHINDFRRMQKLLQRTK--- 428
            ..::.||||||.|:||::|:.|::..:|:.:|||:|. .|...|::....|.|::..|:..:
Zfish   340 KCSACSRMYVPDSLWPQIRQGLLDVYKQIKVGDPVEDFSTFFSAVIDDKSFSRIKGWLEHARSSP 404

  Fly   429 NMEQLCGGSCDDSTGRFVDPTIVRVSDPLDPLLCEPCCGPFLPVFVYSDDSFSEALKLAANQSRY 493
            :::.:.||:|||..|.||:|||:..:||.:.::.|...||.|.|:||.::.:.:.|.|..|.|.|
Zfish   405 HLKIIAGGNCDDKKGYFVEPTIIETTDPQEKIMNEEIFGPVLTVYVYPENDYKKVLHLIDNTSPY 469

  Fly   494 ALSGSIFASQDEVILHCLNQLRMSASNLYVNERCTGSTYGLTPFGGNRLSGTNDKSGSAYFLMRW 558
            ||:|:||.....||......||.:|.|.|:|::.|||.....||||.|.||||||.|..::::||
Zfish   470 ALTGAIFPQDKSVIEEAGKALRNAAGNYYINDKSTGSIVAQQPFGGARASGTNDKPGGPHYVLRW 534

  Fly   559 SSPLLIEET 567
            :||.::::|
Zfish   535 TSPQVVKQT 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6661	NP_648686.3	ALDH-SF	68..567	CDD:299846	188/509 (37%)
aldh4a1	NP_957452.1	ALDH_F4-17_P5CDH	25..546	CDD:143441	191/527 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D293592at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920