DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6661 and P5CDh2

DIOPT Version :9

Sequence 1:	NP_648686.3	Gene:	CG6661 / 39556	FlyBaseID:	FBgn0036403	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_788705.1	Gene:	P5CDh2 / 32625	FlyBaseID:	FBgn0053092	Length:	614	Species:	Drosophila melanogaster

Alignment Length:	564	Identity:	193/564 - (34%)
Similarity:	306/564 - (54%)	Gaps:	36/564 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 GGMAIIKGETKISVDKQKAVQPEQDE----DQQEVEPDSQPAEENPSIHRNQRVLVNHAIQEIQH 80
            ||:..::..:|         :||..|    |:..........:|.    ..:|..:..|:..:.:
  Fly    26 GGLVSVRSTSK---------RPELSEHFTLDEMVANEKLLQYDEG----SKERTELETALLGVLN 77

  Fly    81 RPLEVPTII-GDDTVYTMDTQRVCCPHHLQTNLAHVYYANRKQIEAAIKSALSAQGTWSLVPIAQ 144
            |...||.:| |.:.....|.|:| .|:.:|..:||..:|:|..|:.||..::.||..|..|.::.
  Fly    78 RVEHVPIVINGQEFQAKEDFQQV-LPYDIQQPIAHYGHAHRVLIQMAIDKSVEAQVKWDKVRLSD 141

  Fly   145 RLAIWRRAATIIEEDELRLRVF--LMMTLSKTADDATRDIRRLLTSLRANADYLEHLSE---LRF 204
            |:.||.|||.:| ....|..:.  .|:...||...|..|:..|:..:|.|..:|..|:.   :|
  Fly   142 RIDIWERAAMLI-AGRYRYNIIAATMLGQGKTLRQAEMDVAELVDFMRINPVFLRELANYEPIR- 204

  Fly   205 EIQGDMNVFPSFHLRPMDGFVAALAPFESVALSSSLALCPALMGNTVLWNPSLEVAPVSYLIFRA 269
            :||.  |...|..||.:.|||||::||....::::||..||||||:|:|.||......:|.:|:|
  Fly   205 DIQN--NCRNSMRLRGLSGFVAAISPFNFTGIAANLAYTPALMGNSVIWKPSDSAILSNYFVFKA 267

  Fly   270 FQEAGLPSGVINFVPANERLFLDTITDAVHFAGLNTQASAAFYRHVHKLVSDRMERYICFPRLVA 334
            .:|||:|.||:|||||.|..|...:|.....||:|...::...:.:.:||:..:..|..:||||.
  Fly   268 LREAGVPDGVVNFVPAEETTFASVVTQHPKLAGINFTGTSTVLKVLWQLVAQNINFYQNYPRLVG 332

  Fly   335 ECPGQNFHFVHASAKVESVVSATVQAAFGFAGQYANSLSRMYVPSSMWP-RLREELVEATEQLTI 398
            |..|:||||||:||:.|:.|:.|::|||.:|||..:|.|.:|||.|:|. .:||.|:|.|..|.:
  Fly   333 EGGGKNFHFVHSSAEPETAVACTIRAAFEYAGQKCSSCSMLYVPESLWQNHIREPLLEITASLVV 397

  Fly   399 -GDPIESETDIGAMVHINDFRRMQ---KLLQRTKNMEQLCGGSCDDSTGRFVDPTIVRVSDPLDP 459
             .|....::...|:::...:.|:.   :.:.::.:.:.|.|||||...|.:||||:|.|.| ||.
  Fly   398 RQDATYCDSFCSAVINRRAYDRIYMWLRYIDQSPSCQILVGGSCDKRRGYYVDPTVVLVKD-LDN 461

  Fly   460 LLC-EPCCGPFLPVFVYSDDSFSEALKLAANQSRYALSGSIFASQDEVILHCLNQLRMSASNLYV 523
            ::| |....|.|.|:||.|....|.::..| |..:.|:||:||.....|....:..|::..||.|
  Fly   462 IICREELLAPILGVYVYPDHKLKETMEKVA-QINHGLTGSVFAQDQNFIEEAYDAFRVNVGNLNV 525

  Fly   524 NERCTGSTYGLTPFGGNRLSGTNDKSGSAYFLMRWSSPLLIEET 567
            |::.||...|..|||...::||:||.|:.:.|:||:||.:|:|:
  Fly   526 NDKSTGLMVGQQPFGAGHMTGTSDKLGTPHSLLRWTSPQVIKES 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6661	NP_648686.3	ALDH-SF	68..567	CDD:299846	184/510 (36%)
P5CDh2	NP_788705.1	ALDH-SF	50..570	CDD:299846	186/531 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469346
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S619
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D293592at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42862
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.800