Protein Alignment CG6661 and Aldh1l2

DIOPT Version :10

• Sequence 1: NP_648686.3
• Gene: CG6661 / 39556
• FlyBaseID: FBgn0036403
• Length: 581
• Species: Drosophila melanogaster
• Sequence 2: NP_001178707.2
• Gene: Aldh1l2 / 299699
• RGDID: 1309458
• Length: 923
• Species: Rattus norvegicus
• Alignment Length: 573
• Identity: 124/573 - (21%)
• Similarity: 230/573 - (40%)
• Gaps: 96/573 - (16%)

  Fly     5 GLAVPTRWSFRCRRLGGMAIIKGETKISVDKQKAVQPEQDEDQQEVEPDSQPAEENPSIHRNQRV 69
            ||.:.....:..|:.|...            ||.|:..:.|||:        ||          :
  Rat   391 GLQLQNEDVYMARKFGDFI------------QKVVRRLRGEDQE--------AE----------L 425

  Fly    70 LVNHAIQEIQHRPLEVP--TIIGDDTVYTMDTQRVCCPHHLQ-TNLAHVYYANRKQIEAAIKSAL 131
            :|::..:|:....:::|  ..|....|...|.:.....:... |.|..|.||:...::.|:.:|.
  Rat   426 VVDYVSKEVNEMTVKMPYQCFINGQFVDAEDGETYATINPTDGTTLCRVSYASLADVDRAVAAAK 490

  Fly   132 SA--QGTWSLVPIAQRLAIWRRAATIIEEDELRLRVF------LMMTLS-KTADDATRDIRRLLT 187
            .|  .|.|..:....|..:..|.|.::||::..|...      .:.||: ||      .|...:.
  Rat   491 DAFENGEWGRMNARDRGRLMYRLADLMEENQEELATIEALDSGAVYTLALKT------HIGMSVQ 549

  Fly   188 SLRANADYLEHLSELRFEIQGDMNVFPSFHLRPMDGFV--AALAP--FESVALSSSLALCPALMG 248
            :.|..|.:.:.: ::..|.:....:..:..:...:..|  |.:.|  :..:.|:...|.|.| .|
  Rat   550 TFRYFAGWCDKI-QVTKEPENQARIHDTLGMSSEEPKVVCAIIIPWNYPLMMLAWKSAACLA-AG 612

  Fly   249 NTVLWNPSLEVAPVSYLIFRAFQ-EAGLPSGVINFVP-----ANERLFLDTITDAVHFAGLNTQA 307
            ||::..|: :|.|::.|.|.... :||.|.||||.:|     |.:||........:.|.|
  Rat   613 NTLVLKPA-QVTPLTALKFAELTVKAGFPKGVINIIPGSGGVAGQRLSQHPDIRKLGFTG----- 671

  Fly   308 SAAFYRHVHK--LVSDRMERYICFPRLVAECPGQNFHFVHASAKVESVVSATVQAAFGFAGQYAN 370
            |.:..:.:.|  .||:       ..::..|..|::...:.:..:::..|...:.|.|...|:...
  Rat   672 STSVGKQIMKSCAVSN-------LKKVSLELGGKSPLIIFSDCELDKAVRMGMGAVFFNKGENCI 729

  Fly   371 SLSRMYVPSSMWPRLREELVEATEQLTIGDPIESETDIGAMVHINDFRRMQKLLQR-----TKNM 430
            :..|::|..::.......:||..:::.||||::..||.|..   |....::||||.     .:..
  Rat   730 AAGRLFVEEAIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQ---NHKAHLEKLLQYCETGVKEGA 791

  Fly   431 EQLCGGSCDDSTGRFVDPTIVRVSDPLDPLLCEPCCGPFLPVFVYSDDSFSEALKLAANQSRYAL 495
            ..:.||......|.|::||:....:....|..|...||.:.:..:.:......|: .||.:.|.|
  Rat   792 TLVYGGRQVQRPGFFMEPTVFTGVEDHMYLAKEESFGPIMVISKFQNGDIDGVLQ-RANNTEYGL 855

  Fly   496 SGSIFASQDEVILHCLNQLRMSASNLYVNERCTGSTYGLT----PFGGNRLSG 544
            :..:|.......::..:  |:.|..:::|      ||..|    ||||.:.||
  Rat   856 ASGVFTRDISKAMYVSD--RLEAGTVFIN------TYNKTDVAAPFGGVKQSG 900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6661	NP_648686.3	ALDH-SF	68..567	CDD:448367	112/510 (22%)
Aldh1l2	NP_001178707.2	FMT_core_FDH_N	23..225	CDD:187716
		FDH_Hydrolase_C	228..327	CDD:187731
		PP-binding	346..>390	CDD:425746
		ALDH_F1L_FTFDH	438..923	CDD:143458	110/496 (22%)