DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6661 and Aldh2

DIOPT Version :9

Sequence 1:	NP_648686.3	Gene:	CG6661 / 39556	FlyBaseID:	FBgn0036403	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_115792.2	Gene:	Aldh2 / 29539	RGDID:	69219	Length:	519	Species:	Rattus norvegicus

Alignment Length:	545	Identity:	127/545 - (23%)
Similarity:	219/545 - (40%)	Gaps:	76/545 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 PA-EENPSIHRNQRVLVNHAIQEIQHRPLEVPTIIGDDTVYTMDTQRVCCPHHLQTNLAHVYYAN 119
            || .:.|.:..||..:.|.....:..:..  ||:       ...|..|.|         .|...|
  Rat    28 PAPNQQPEVFCNQIFINNEWHDAVSKKTF--PTV-------NPSTGEVIC---------QVAEGN 74

  Fly   120 RKQIEAAIKSALSA---QGTWSLVPIAQRLAIWRRAATIIEEDELRLRVFLMMTLSKTADDATR- 180
            ::.::.|:|:|.:|   ...|..:..:.|..:..|.|.:||.|...|...      :|.|:...
  Rat    75 KEDVDKAVKAARAAFQLGSPWRRMDASDRGRLLYRLADLIERDRTYLAAL------ETLDNGKPY 133

  Fly   181 ------DIRRLLTSLRANADYLEHLSELRFEIQGDMNVFPSFHLRPMDGFVAALAPFESVALSSS 239
                  |:..:|..||..|.:.:........|.||   |.|:......|....:.|:....|..:
  Rat   134 VISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGD---FFSYTRHEPVGVCGQIIPWNFPLLMQA 195

  Fly   240 LALCPAL-MGNTVLWNPSLEVAPVSYLIFRAFQEAGLPSGVINFVP-----ANERLFLDTITDAV 298
            ..|.||| .||.|:...:.:....:..:....:|||.|.||:|.||     |...:......|.|
  Rat   196 WKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKV 260

  Fly   299 HFAGLNTQASAAFYRHVHKLVSDRMERYICFPRLVAECPGQNFHFVHASAKVESVVSATVQAAFG 363
            .|.| :|:..     |:.::.:....    ..|:..|..|::.:.:.:.|.::..|.....|.|.
  Rat   261 AFTG-STEVG-----HLIQVAAGSSN----LKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFF 315

  Fly   364 FAGQYANSLSRMYVPSSMWPRLREELVEATEQLTIGDPIESETDIGAMVHINDFRRMQKLLQRTK 428
            ..||...:.||.:|...::....|..|...:...:|:|.:|.|:.|..|   |..:.:|:|...|
  Rat   316 NQGQCCCAGSRTFVQEDVYDEFVERSVARAKSRVVGNPFDSRTEQGPQV---DETQFKKILGYIK 377

  Fly   429 NMEQ-----LCGGSCDDSTGRFVDPTIV-RVSDPLDPLLCEPCCGPFLPVFVYSDDSFSEALKLA 487
            :.:|     ||||......|.|:.||:. .|.|.: .:..|...||.:.:..:..   .|.:...
  Rat   378 SGQQEGAKLLCGGGAAADRGYFIQPTVFGDVKDGM-TIAKEEIFGPVMQILKFKT---IEEVVGR 438

  Fly   488 ANQSRYALSGSIFASQDEVILHCLNQLRMSASNLYVNERCTGSTYGLTPFGGNRLSGTNDKSGSA 552
            ||.|:|.|:.::| ::|....:.|:| .:.|..:::|  |.......:||||.::||:..:.|.
  Rat   439 ANNSKYGLAAAVF-TKDLDKANYLSQ-ALQAGTVWIN--CYDVFGAQSPFGGYKMSGSGRELGE- 498

  Fly   553 YFLMRWSSPLLIEETVDGPPPMRGS 577
            |.|..::.    .:||....|.:.|
  Rat   499 YGLQAYTE----VKTVTVKVPQKNS 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6661	NP_648686.3	ALDH-SF	68..567	CDD:299846	118/520 (23%)
Aldh2	NP_115792.2	ALDH_F1AB_F2_RALDH1	33..513	CDD:143459	123/532 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810