DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6661 and Aldh7a1

DIOPT Version :9

Sequence 1:	NP_648686.3	Gene:	CG6661 / 39556	FlyBaseID:	FBgn0036403	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001258034.1	Gene:	Aldh7a1 / 291450	RGDID:	1308614	Length:	539	Species:	Rattus norvegicus

Alignment Length:	482	Identity:	114/482 - (23%)
Similarity:	198/482 - (41%)	Gaps:	75/482 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 CPHHLQTNLAHVYYANRKQIEAAIKSALSAQGTWSLVPIAQRLAIWRRAATIIEEDELRLRVFLM 168
            ||.:.:. :|.|..|:.|..|..|..|..|...|:.:|..:|..|.|:....:.|....|...:.
  Rat    70 CPANNEP-IARVRQASMKDYEETIGKAKKAWNIWADIPAPKRGEIVRKIGDALREKIQLLGRLVS 133

  Fly   169 MTLSKTADDATRDIRRLLTSLRANADYLEHLSELRFEIQGDMNVFPSFHLRP----MD-----GF 224
            :.:.|...:...:::..:..    .||...||.:   |.|.  ..||  .||    |:     |.
  Rat   134 LEMGKILVEGIGEVQEYVDV----CDYAAGLSRM---IGGP--TLPS--ERPGHALMEQWNPLGL 187

  Fly   225 VAALAPFE-SVAL---SSSLALCPALMGNTVLW----NPSLEVAPVSYLIFRAFQEAGLPSGVIN 281
            |..:..|. .||:   ::::||   :.||..||    ..||....|:.:|.:..::..||..:.:
  Rat   188 VGIITAFNFPVAVFGWNNAIAL---ITGNVCLWKGAPTTSLVSIAVTKIIAKVLEDNLLPGAICS 249

  Fly   282 F----------VPANERLFLDTITDAVHFAGLNTQASAAFYRHVHKLVSDRMERYICFPRLVAEC 336
            .          :..:||:.|      :.|.| :||..    :.|..:|.:|      |.:.:.|.
  Rat   250 LTCGGADMGTAMARDERVNL------LSFTG-STQVG----KQVALMVQER------FGKSLLEL 297

  Fly   337 PGQNFHFVHASAKVESVVSATVQAAFGFAGQYANSLSRMYVPSSMWPRLREELVEATEQLTIGDP 401
            .|.|.......|.:..|:.:.:.||.|.|||...::.|:::..|:...:.:.|..|..|:.:|:|
  Rat   298 GGNNAIIAFEDADLSLVLPSALFAAVGTAGQRCTTVRRLFLHESIHDEVVDRLKNAYSQIRVGNP 362

  Fly   402 IESETDIGAMVHINDFRRMQKLLQRTKNMEQ-----LCGGSCDDSTGRFVDPTIVR--VSDPLDP 459
            .:.....|.: |..  :.:...:|..:..::     :.||...|..|.:|:||||.  |.|.  |
  Rat   363 WDPNILYGPL-HTK--QAVSMFVQAVEEAKKEGGTVVYGGKVMDHPGNYVEPTIVTGLVHDA--P 422

  Fly   460 LLCEPCCGPFLPVFVYSDDSFSEALKLAANQSRYALSGSIFASQDEVILHCLNQLRMSASNLYVN 524
            ::.:....|.|.||.:.::   |.:....|:.:..||.|||......|...|.........:.||
  Rat   423 IVHKETFAPILYVFKFKNE---EEVFEWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVN 484

  Fly   525 ERCTGSTYGLTPFGGNRLSGTNDKSGS 551
            ...:|:..| ..|||.:.:|...:|||
  Rat   485 IPTSGAEIG-GAFGGEKHTGGGRESGS 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6661	NP_648686.3	ALDH-SF	68..567	CDD:299846	114/482 (24%)
Aldh7a1	NP_001258034.1	ALDH_F7_AASADH	53..527	CDD:143448	114/482 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900