Protein Alignment CG6661 and ALDH2

DIOPT Version :9

• Sequence 1: NP_648686.3
• Gene: CG6661 / 39556
• FlyBaseID: FBgn0036403
• Length: 581
• Species: Drosophila melanogaster
• Sequence 2: NP_000681.2
• Gene: ALDH2 / 217
• HGNCID: 404
• Length: 517
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 127/549 - (23%)
• Similarity: 217/549 - (39%)
• Gaps: 84/549 - (15%)

  Fly    56 PA-EENPSIHRNQRVLVNHAIQEIQHRPLEVPTIIGDDTVYTMDTQRVCCPHHLQTNLAHVYYAN 119
            || .:.|.:..|| :.:|:...:...|. ..||:       ...|..|.|         .|...:
Human    26 PAPNQQPEVFCNQ-IFINNEWHDAVSRK-TFPTV-------NPSTGEVIC---------QVAEGD 72

  Fly   120 RKQIEAAIKSALSA---QGTWSLVPIAQRLAIWRRAATIIEEDELRLRVFLMMTLSKTADDATR- 180
            ::.::.|:|:|.:|   ...|..:..:.|..:..|.|.:||.|...|...      :|.|:...
Human    73 KEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAAL------ETLDNGKPY 131

  Fly   181 ------DIRRLLTSLRANADYLEHLSELRFEIQGDMNVFPSFHLRPMDGFVAALAPFESVALSSS 239
                  |:..:|..||..|.:.:........|.||   |.|:......|....:.|:....|..:
Human   132 VISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGD---FFSYTRHEPVGVCGQIIPWNFPLLMQA 193

  Fly   240 LALCPAL-MGNTVLWNPSLEVAPVSYLIFRAFQEAGLPSGVINFVPANERLFLDTITDAVHFAGL 303
            ..|.||| .||.|:...:.:....:..:....:|||.|.||:|.||                 |.
Human   194 WKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVP-----------------GF 241

  Fly   304 NTQASAAFYRH--VHKLV---SDRMERYI-------CFPRLVAECPGQNFHFVHASAKVESVVSA 356
            ...|.||...|  |.|:.   |..:.|.|       ...|:..|..|::.:.:.:.|.::..|..
Human   242 GPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQ 306

  Fly   357 TVQAAFGFAGQYANSLSRMYVPSSMWPRLREELVEATEQLTIGDPIESETDIGAMVHINDFRRMQ 421
            ...|.|...||...:.||.:|...::....|..|...:...:|:|.:|:|:.|..|....|:::.
Human   307 AHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKIL 371

  Fly   422 KLLQ--RTKNMEQLCGGSCDDSTGRFVDPTIV-RVSDPLDPLLCEPCCGPFLPVFVYSDDSFSEA 483
            ..:.  :.:..:.||||......|.|:.||:. .|.|.: .:..|...||.:.:..:..   .|.
Human   372 GYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGM-TIAKEEIFGPVMQILKFKT---IEE 432

  Fly   484 LKLAANQSRYALSGSIFASQDEVILHCLNQLRMSASNLYVNERCTGSTYGLTPFGGNRLSGTNDK 548
            :...||.|.|.|:.::| ::|....:.|:| .:.|..::||  |.......:||||.::||:..:
Human   433 VVGRANNSTYGLAAAVF-TKDLDKANYLSQ-ALQAGTVWVN--CYDVFGAQSPFGGYKMSGSGRE 493

  Fly   549 SGSAYFLMRWSSPLLIEETVDGPPPMRGS 577
            .|. |.|..::.    .:||....|.:.|
Human   494 LGE-YGLQAYTE----VKTVTVKVPQKNS 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6661	NP_648686.3	ALDH-SF	68..567	CDD:299846	118/524 (23%)
ALDH2	NP_000681.2	ALDH_F1AB_F2_RALDH1	31..511	CDD:143459	123/536 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810