Protein Alignment CG6661 and ALDH1A1

DIOPT Version :10

• Sequence 1: NP_648686.3
• Gene: CG6661 / 39556
• FlyBaseID: FBgn0036403
• Length: 581
• Species: Drosophila melanogaster
• Sequence 2: NP_000680.2
• Gene: ALDH1A1 / 216
• HGNCID: 402
• Length: 501
• Species: Homo sapiens
• Alignment Length: 470
• Identity: 113/470 - (24%)
• Similarity: 192/470 - (40%)
• Gaps: 56/470 - (11%)

  Fly   109 QTNLAHVYYANRKQIEAAIKSALSA---QGTWSLVPIAQRLAIWRRAATIIEEDELRLRVFLMMT 170
            :..|..|...:::.::.|:|:|..|   ...|..:..::|..:..:.|.:||.|.|.|.....|.
Human    46 EEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMN 110

  Fly   171 LSKTADDA-TRDIRRLLTSLRANADYLEHLSELRFEIQGDMNVFPSFHLRPMDGFVAALAPFESV 234
            ..|...:| ..|:...:.:||..|.:.:.:......|.|  |.|......|: |....:.|:...
Human   111 GGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDG--NFFTYTRHEPI-GVCGQIIPWNFP 172

  Fly   235 ALSSSLALCPAL-MGNTVLWNPSLEVAPVSYL-IFRAFQEAGLPSGVINFVPANERLFLDTITDA 297
            .:.....:.||| .||||:..|: |..|::.| :....:|||.|.||:|.||
Human   173 LVMLIWKIGPALSCGNTVVVKPA-EQTPLTALHVASLIKEAGFPPGVVNIVP------------- 223

  Fly   298 VHFAGLNTQASAAFYRH-------------VHKLVSDRMERYICFPRLVAECPGQNFHFVHASAK 349
                |....|.||...|             |.||:.:...: ....|:..|..|::...|.|.|.
Human   224 ----GYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGK-SNLKRVTLELGGKSPCIVLADAD 283

  Fly   350 VESVVSATVQAAFGFAGQYANSLSRMYVPSSMWPRLREELVEATEQLTIGDPIESETDIGAMVHI 414
            :::.|.......|...||...:.||::|..|::.......||..::..:|:|:......|..:..
Human   284 LDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDK 348

  Fly   415 NDFRRMQKLLQRTK----NMEQLCGGSCDDSTGRFVDPTIV-RVSDPLDPLLCEPCCGPFLPVFV 474
            ..:.::..|::..|    .:|  |||....:.|.||.||:. .|:|.: .:..|...||...:..
Human   349 EQYDKILDLIESGKKEGAKLE--CGGGPWGNKGYFVQPTVFSNVTDEM-RIAKEEIFGPVQQIMK 410

  Fly   475 YSDDSFSEALKLAANQSRYALSGSIFASQDEVILHCLNQLRMSASNLYVNERCTGSTYGLTPFGG 539
            :.  |..:.:| .||.:.|.||..:|....:..:...:.|:  |..::||  |.|......||||
Human   411 FK--SLDDVIK-RANNTFYGLSAGVFTKDIDKAITISSALQ--AGTVWVN--CYGVVSAQCPFGG 468

  Fly   540 NRLSGTNDKSGSAYF 554
            .::||...:.|...|
Human   469 FKMSGNGRELGEYGF 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6661	NP_648686.3	ALDH-SF	68..567	CDD:448367	113/470 (24%)
ALDH1A1	NP_000680.2	ALDH_F1AB_F2_RALDH1	15..495	CDD:143459	113/470 (24%)
		Mediates interaction with PRMT3. /evidence=ECO:0000269|PubMed:33495566	336..501		39/158 (25%)