DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6661 and ALDH1L2

DIOPT Version :9

Sequence 1:	NP_648686.3	Gene:	CG6661 / 39556	FlyBaseID:	FBgn0036403	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001029345.2	Gene:	ALDH1L2 / 160428	HGNCID:	26777	Length:	923	Species:	Homo sapiens

Alignment Length:	571	Identity:	124/571 - (21%)
Similarity:	224/571 - (39%)	Gaps:	100/571 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 RRLGGMAI----IKGETKISVDKQKAVQPEQDEDQQEVEPDSQPAEENPSIHRNQRVLVNHAIQE 77
            ::.||:.:    :...||.....||.|:..:.|| ||||                 ::|::..:|
Human   387 QKCGGLQLQNEDVYMATKFEGFIQKVVRKLRGED-QEVE-----------------LVVDYISKE 433

  Fly    78 IQHRPLEVP---------TIIGD----DTVYTMDTQRVCCPHHLQTNLAHVYYANRKQIEAAIKS 129
            :....:::|         |...|    ||:...|...:|          .|.||:...::.|:.:
Human   434 VNEIMVKMPYQCFINGQFTDADDGKTYDTINPTDGSTIC----------KVSYASLADVDKAVAA 488

  Fly   130 ALSA--QGTWSLVPIAQRLAIWRRAATIIEEDELRLRVFLMMTLSKTADDATRDIRRLLTSLRAN 192
            |..|  .|.|..:...:|..:..|.|.::||::..|...      :..|........|.|.:..:
Human   489 AKDAFENGEWGRMNARERGRLMYRLADLLEENQEELATI------EALDSGAVYTLALKTHIGMS 547

  Fly   193 ADYLEHLSELRFEIQGDMNVFPSFHLRPMD----------GFVAALAP--FESVALSSSLALCPA 245
            .....:.:....:|||  :..|....||..          |..|.:.|  :..:.|:...|.|.|
Human   548 VQTFRYFAGWCDKIQG--STIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLA 610

  Fly   246 LMGNTVLWNPSLEVAPVSYLIFRAFQ-EAGLPSGVINFVPANERLFLDTITDAVHFAGLNTQASA 309
             .|||::..|: :|.|::.|.|.... :||.|.||||.:|.:..:....:::......|....|.
Human   611 -AGNTLVLKPA-QVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGST 673

  Fly   310 AFYRHVHK--LVSDRMERYICFPRLVAECPGQNFHFVHASAKVESVVSATVQAAFGFAGQYANSL 372
            ...:.:.|  .||:       ..::..|..|::...:....:::..|...:.|.|...|:...:.
Human   674 PIGKQIMKSCAVSN-------LKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAA 731

  Fly   373 SRMYVPSSMWPRLREELVEATEQLTIGDPIESETDIGAMVHINDFRRMQKLLQR-----TKNMEQ 432
            .|::|..|:.......:||..:::.||||::..||.|..   |....::||||.     .:....
Human   732 GRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQ---NHKAHLEKLLQYCETGVKEGATL 793

  Fly   433 LCGGSCDDSTGRFVDPTIVRVSDPLDPLLCEPCCGPFLPVFVYSDDSFSEALKLAANQSRYALSG 497
            :.||......|.|::||:....:....|..|...||.:.:..:.:......|: .||.:.|.|:.
Human   794 VYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQ-RANSTEYGLAS 857

  Fly   498 SIFASQDEVILHCLNQLRMSASNLYVNERCTGSTYGLT----PFGGNRLSG 544
            .:|.......::...:|  .|..:::|      ||..|    ||||.:.||
Human   858 GVFTRDINKAMYVSEKL--EAGTVFIN------TYNKTDVAAPFGGVKQSG 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6661	NP_648686.3	ALDH-SF	68..567	CDD:299846	111/516 (22%)
ALDH1L2	NP_001029345.2	Fmt	22..326	CDD:223301
		FMT_core_FDH_N	23..225	CDD:187716
		GART	23..225
		FDH_Hydrolase_C	228..327	CDD:187731
		PP-binding	346..>390	CDD:278949	0/2 (0%)
		Aldehyde dehydrogenase	438..923		109/502 (22%)
		ALDH_F1L_FTFDH	439..923	CDD:143458	109/501 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810