DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6661 and ALDH16A1

DIOPT Version :10

Sequence 1:NP_648686.3 Gene:CG6661 / 39556 FlyBaseID:FBgn0036403 Length:581 Species:Drosophila melanogaster
Sequence 2:NP_699160.2 Gene:ALDH16A1 / 126133 HGNCID:28114 Length:802 Species:Homo sapiens


Alignment Length:507 Identity:117/507 - (23%)
Similarity:181/507 - (35%) Gaps:115/507 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    97 MDTQRVCCPHHLQ--------------------TNLAHVYYANRKQIEAAIKSALSAQGTWSLVP 141
            :|||..|..|::.                    .|||....|..:.:.||:::|..|...||..|
Human    33 LDTQDRCLGHYVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHP 97

  Fly   142 IAQRLAIWRRAATIIEEDELRLRVFLMMTL-SKTADDATRDIRRLLTSLRANADYLEHLSELRFE 205
            ...|.....|.|.:|::.:.     |:.|| |.....|.|::|.....|   |..|.|...::..
Human    98 GVVRAQHLTRLAEVIQKHQR-----LLWTLESLVTGRAVREVRDGDVQL---AQQLLHYHAIQAS 154

  Fly   206 IQGDMNVFPSFHLRPMDGFVAALAPFESVALSSSLALCPAL-MGNTV--LWNPSLEVAPVSYLIF 267
            .|.:...    ...|| |.:..:.|.....|.....:|||| :|.||  |..|:   :|...|:.
Human   155 TQEEALA----GWEPM-GVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPA---SPAPLLLA 211

  Fly   268 RAFQEAGLPSGVINFV--PANERLFLDTITDA------VHFAGLNTQASAAFYRHVHKLVSDRME 324
            :...|.|...|::|.:  ||:    |..|..:      |.|.|...:..|             :.
Human   212 QLAGELGPFPGILNVLSGPAS----LVPILASQPGIRKVAFCGAPEEGRA-------------LR 259

  Fly   325 RYICFPRLVAECP-------GQNFHFVHASAKVESVVSATVQAAFGFAGQYANSLSRMYVPSSMW 382
            |     .|..||.       .::...:..:|.|:|.|...|.||:...|...   .|:.:..|:|
Human   260 R-----SLAGECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGPGG---LRLLIQESVW 316

  Fly   383 PRLREELVEATEQLTIGDPIESETDIGAMVHINDFRRMQKLLQRTKNMEQLCGGSC----DDSTG 443
            ......|.|...:|..|..::...|:||.     ......|:||.....|..|...    |..:.
Human   317 DEAMRRLQERMGRLRSGRGLDGAVDMGAR-----GAAACDLVQRFVREAQSQGAQVFQAGDVPSE 376

  Fly   444 R-FVDPTIVRVSDPLDPLLCEPCCGPFLPVFVYSDDSFSEALKLAANQSRYALSGSIFASQDEVI 507
            | |..||:|....|..|  |.....|: ||.|.|....::...|.||.:....|.|:::.:    
Human   377 RPFYPPTLVSNLPPASP--CAQVEVPW-PVVVASPFRTAKEALLVANGTPRGGSASVWSER---- 434

  Fly   508 LHCLNQ-----LRMSASNLYVNERCTGSTYGL----TPFGGNRLSGTNDKSG 550
               |.|     ..:....:::|      .:||    .|.||.:.||.:...|
Human   435 ---LGQALELGYGLQVGTVWIN------AHGLRDPSVPTGGCKESGCSWHGG 477

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6661NP_648686.3 ALDH-SF 68..567 CDD:448367 117/507 (23%)
ALDH16A1NP_699160.2 ALDH-SF 19..492 CDD:448367 117/507 (23%)
AdhE 525..>767 CDD:440636
Blue background indicates that the domain is not in the aligned region.

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