DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6661 and Aldh2

DIOPT Version :9

Sequence 1:	NP_648686.3	Gene:	CG6661 / 39556	FlyBaseID:	FBgn0036403	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_033786.1	Gene:	Aldh2 / 11669	MGIID:	99600	Length:	519	Species:	Mus musculus

Alignment Length:	545	Identity:	128/545 - (23%)
Similarity:	221/545 - (40%)	Gaps:	76/545 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 PA-EENPSIHRNQRVLVNHAIQEIQHRPLEVPTIIGDDTVYTMDTQRVCCPHHLQTNLAHVYYAN 119
            || ...|.:..|| :.:|:...:...|. ..||:       ...|..|.|         .|...|
Mouse    28 PAPNHQPEVFCNQ-IFINNEWHDAVSRK-TFPTV-------NPSTGEVIC---------QVAEGN 74

  Fly   120 RKQIEAAIKSALSA---QGTWSLVPIAQRLAIWRRAATIIEEDELRLRVFLMMTLSKTADDATR- 180
            ::.::.|:|:|.:|   ...|..:..:.|..:..|.|.:||.|...|...      :|.|:...
Mouse    75 KEDVDKAVKAARAAFQLGSPWRRMDASDRGRLLYRLADLIERDRTYLAAL------ETLDNGKPY 133

  Fly   181 ------DIRRLLTSLRANADYLEHLSELRFEIQGDMNVFPSFHLRPMDGFVAALAPFESVALSSS 239
                  |:..:|..||..|.:.:........|.||   |.|:......|....:.|:....|..:
Mouse   134 VISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGD---FFSYTRHEPVGVCGQIIPWNFPLLMQA 195

  Fly   240 LALCPAL-MGNTVLWNPSLEVAPVSYLIFRAFQEAGLPSGVINFVP-----ANERLFLDTITDAV 298
            ..|.||| .||.|:...:.:....:..:....:|||.|.||:|.||     |...:......|.|
Mouse   196 WKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEGVDKV 260

  Fly   299 HFAGLNTQASAAFYRHVHKLVSDRMERYICFPRLVAECPGQNFHFVHASAKVESVVSATVQAAFG 363
            .|.| :|:..     |:.::.:....    ..|:..|..|::.:.:.:.|.::..|.....|.|.
Mouse   261 AFTG-STEVG-----HLIQVAAGSSN----LKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFF 315

  Fly   364 FAGQYANSLSRMYVPSSMWPRLREELVEATEQLTIGDPIESETDIGAMVHINDFRRMQKLLQRTK 428
            ..||...:.||.:|..:::....|..|...:...:|:|.:|.|:.|..|   |..:.:|:|...|
Mouse   316 NQGQCCCAGSRTFVQENVYDEFVERSVARAKSRVVGNPFDSRTEQGPQV---DETQFKKILGYIK 377

  Fly   429 NMEQ-----LCGGSCDDSTGRFVDPTIV-RVSDPLDPLLCEPCCGPFLPVFVYSDDSFSEALKLA 487
            :.:|     ||||......|.|:.||:. .|.|.: .:..|...||.:.:..:..   .|.:...
Mouse   378 SGQQEGAKLLCGGGAAADRGYFIQPTVFGDVKDGM-TIAKEEIFGPVMQILKFKT---IEEVVGR 438

  Fly   488 ANQSRYALSGSIFASQDEVILHCLNQLRMSASNLYVNERCTGSTYGLTPFGGNRLSGTNDKSGSA 552
            ||.|:|.|:.::| ::|....:.|:| .:.|..:::|  |.......:||||.::||:..:.|.
Mouse   439 ANDSKYGLAAAVF-TKDLDKANYLSQ-ALQAGTVWIN--CYDVFGAQSPFGGYKMSGSGRELGE- 498

  Fly   553 YFLMRWSSPLLIEETVDGPPPMRGS 577
            |.|..::.    .:||....|.:.|
Mouse   499 YGLQAYTE----VKTVTVKVPQKNS 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6661	NP_648686.3	ALDH-SF	68..567	CDD:299846	119/520 (23%)
Aldh2	NP_033786.1	PLN02466	3..518	CDD:215259	127/542 (23%)
Aldh2	NP_033786.1	ALDH_F1AB_F2_RALDH1	33..513	CDD:143459	124/532 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810