DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6661 and ALDH1L1

DIOPT Version :9

Sequence 1:	NP_648686.3	Gene:	CG6661 / 39556	FlyBaseID:	FBgn0036403	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001257293.1	Gene:	ALDH1L1 / 10840	HGNCID:	3978	Length:	912	Species:	Homo sapiens

Alignment Length:	520	Identity:	111/520 - (21%)
Similarity:	206/520 - (39%)	Gaps:	76/520 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 VNHAIQEIQHRPLEVP--TIIG-----------DDTVYTMDTQRVCCPHHLQTNLAHVYYANRKQ 122
            :::....:..|.:.:|  ..||           .:|:...|...:|     |.:||.|     ..
Human   416 IDYVEMAVNKRTVRMPHQLFIGGEFVDAEGAKTSETINPTDGSVIC-----QVSLAQV-----TD 470

  Fly   123 IEAAIKSALSA--QGTWSLVPIAQRLAIWRRAATIIEEDELRLRVFLMMTLSKTADDATRDIRRL 185
            ::.|:.:|..|  .|.|..:....|..:..|.|.::|:.:..|...      :..|........|
Human   471 VDKAVAAAKDAFENGRWGKISARDRGRLMYRLADLMEQHQEELATI------EALDAGAVYTLAL 529

  Fly   186 LTSLRANADYLEHLSELRFEIQGDMNVFPSFHLRPMD----------GFVAALAP--FESVALSS 238
            .|.:..:.....:.:....:|||  :..|....||..          |....:.|  :..:.||.
Human   530 KTHVGMSIQTFRYFAGWCDKIQG--STIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSW 592

  Fly   239 SLALCPALMGNTVLWNPSLEVAPVSYLIFRAFQ-EAGLPSGVINFVPANERLFLDTITDAVHFAG 302
            ..|.|.| .||||:..|: :|.|::.|.|.... :||:|.||:|.:|.:..|....::|......
Human   593 KTAACLA-AGNTVVIKPA-QVTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRK 655

  Fly   303 LNTQASAAFYRHVHK--LVSDRMERYICFPRLVAECPGQNFHFVHASAKVESVVSATVQAAFGFA 365
            :....|....:|:.|  .:|:       ..::..|..|::...:.|...:...|...:.:.|...
Human   656 IGFTGSTEVGKHIMKSCAISN-------VKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNK 713

  Fly   366 GQYANSLSRMYVPSSMWPRLREELVEATEQLTIGDPIESETDIGAMVHINDFRRMQKLLQR--TK 428
            |:...:..|::|..|:.......:||...::.:|:|::.:||.|...|.....::.:..|.  .:
Human   714 GENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKE 778

  Fly   429 NMEQLCGGSCDDSTGRFVDPTIVRVSDPLDPLLC--EPCCGPFLPVFVYSDDSFSEALKLAANQS 491
            ....:|||:.....|.|.:||:  .:|..|.:..  |...||.:.:..::|... :|:...||.:
Human   779 GATLVCGGNQVPRPGFFFEPTV--FTDVEDHMFIAKEESFGPVMIISRFADGDL-DAVLSRANAT 840

  Fly   492 RYALSGSIFASQDEVILHCLNQLRMSASNLYVNERCTGSTYGLT----PFGGNRLSGTNDKSGSA 552
            .:.|:..:|.......|:..::|:  |..::||      ||..|    ||||.:.||.....|.|
Human   841 EFGLASGVFTRDINKALYVSDKLQ--AGTVFVN------TYNKTDVAAPFGGFKQSGFGKDLGEA 897

Fly 553 552
Human 898 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6661	NP_648686.3	ALDH-SF	68..567	CDD:299846	111/520 (21%)
ALDH1L1	NP_001257293.1	Fmt	10..319	CDD:223301
		FMT_core_FDH_N	11..213	CDD:187716
		FDH_Hydrolase_C	216..316	CDD:187731
		PP-binding	335..401	CDD:278949
		ALDH_F1L_FTFDH	427..912	CDD:143458	110/509 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810