DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6650 and adpgk2

DIOPT Version :9

Sequence 1:	NP_001246747.1	Gene:	CG6650 / 39555	FlyBaseID:	FBgn0036402	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_694757.3	Gene:	adpgk2 / 566398	ZFINID:	ZDB-GENE-090609-3	Length:	482	Species:	Danio rerio

Alignment Length:	505	Identity:	210/505 - (41%)
Similarity:	298/505 - (59%)	Gaps:	32/505 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTALRYMGWITGCSVLTAFVSIIWQAFIALQTL-NRTTVLLTGLLAIEGSLKRTALEPAPKVAIG 64
            ::.::|...::...||.|:    |........| :|...:|:.||..|..:....:. .|:||||
Zfish     6 LSGVKYGSLLSLAVVLVAY----WFRSPDSSVLDDRLDAVLSSLLRAERKVGMNGVS-RPRVAIG 65

  Fly    65 YGACTDLQINATEFLDRYYGRRIPVAAATTGS---RAVVNNEDELLQSFAYYFQNGAAAERVMAN 126
            :|.|.|:.::....|::       :....|..   ...:.|.::|.|||||:|..|||:||.:.|
Zfish    66 FGGCVDIIVDGVTLLNK-------IGLKPTDQPLHHDYIENAEQLAQSFAYFFSPGAASERFVVN 123

  Fly   127 STLFTQLVGYAKVMDKERINWYMGGNAPLMAVRFFMEGAQVLLGAHMSRKLRPLLPKEIRLAGDE 191
            .|||::||..::.:...|  |.:|||||:||.|..:||..||||...|.....:|.:.|.:||:.
Zfish   124 DTLFSELVEASRELPGNR--WSIGGNAPVMASRMALEGCDVLLGGSFSTDFTDILSQRITVAGNT 186

  Fly   192 IPNDDIHLILEYKAGDKWGPYVAPRANRYILHNDRNNPHLRAVEQLTDALKMYQPQLLVVSGLQM 256
            :...||||||||..|..||||.:.||||||:|:|.:||:|.::||..:.|..::|.||||.||||
Zfish   187 VDEPDIHLILEYPTGATWGPYTSRRANRYIVHSDDHNPYLDSMEQFQEMLNSFKPDLLVVGGLQM 251

  Fly   257 MDMFTFKSGEREARLQQVQRQLTSQPQGTLNHFEMASYVELQLLQQLRHFVLPYVDSLGMNEQEL 321
            ||.|.||.||||..|.|:...|:|....|..||||||:|:..|:..|..||||:.||||||||||
Zfish   252 MDNFPFKRGEREDLLGQLANMLSSVSPQTAVHFEMASFVDEDLMSDLLEFVLPHADSLGMNEQEL 316

  Fly   322 SNLQQVLAHGRTTLATDWNPRIAHTLDQMRQVFISLLEDYEDRSSSDAKRRSISRIHVHTLAYQA 386
            .||..:......|:.:|.|||:|..|||||.::..:.:.:.:....    ||::|:||||||:||
Zfish   317 PNLLSLFRGSNLTVLSDPNPRVATVLDQMRDLYRLVNQRHREAGMG----RSLTRLHVHTLAFQA 377

  Fly   387 ILTTAGSKWKNTRAAAAKAALTAHRYVCKSQFINPEAVLQVLDDSFATSAQADAPRMRIGAASPV 451
            |:...||:||||.:|.|||:|.|:|:||.|..|:......::|:||:.|.|..:.|:.:..:.||
Zfish   378 IIVKRGSQWKNTMSATAKASLVANRHVCGSPDIDLSKARLIMDESFSISRQEGSQRIPLQESRPV 442

  Fly   452 PCWREYIQYGRHRQRLEVEICVAPVLVCREARKTAGAGDNISASGLAAQL 501
            .||.|.:          .||||||||||.|..:|||.||||||:||..|:
Zfish   443 SCWDEDV----------FEICVAPVLVCTEVYQTAGGGDNISAAGLVLQI 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6650	NP_001246747.1	ADPGK_ADPPFK	23..501	CDD:238913	205/481 (43%)
adpgk2	XP_694757.3	ADP_PFK_GK	60..478	CDD:282449	196/440 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580372
Domainoid	1	1.000	364	1.000	Domainoid score	I893
eggNOG	1	0.900	-	-		E1_COG4809
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H71824
Inparanoid	1	1.050	370	1.000	Inparanoid score	I2084
OMA	1	1.010	-	-		QHG54964
OrthoDB	1	1.010	-	-		D1036373at2759
OrthoFinder	1	1.000	-	-		FOG0005174
OrthoInspector	1	1.000	-	-		oto39947
orthoMCL	1	0.900	-	-		OOG6_105910
Panther	1	1.100	-	-	LDO	PTHR21208
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2388
SonicParanoid	1	1.000	-	-		X4207
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800